Abstract: The invention relates to 5-substituted-1-(2'-deoxy-2'-substituted-beta-D-Arabinofuranoysyl) pyrimidine compounds and their use in a method for the treatment of hepatitis B viruses.

Abstract: Veterinarian composition for the treatment of herpes virus in animals comprising a pyrimidine nucleoside, or veterinarianically acceptable acid addition salte thereof, of the formula ##STR1## wherein A is OR.sup.3, SR.sup.3, NR.sup.3 R.sup.4 or NHacyl wherein R.sup.3 and R.sup.4 are the same or different and are hydrogen, lower alkyl of 1 to 7 carbon atoms, aralkyl, or aryl;NHacyl is alkanoyl or aroyl amide;B is oxygen or sulfur;X is halogen, alkylsulfonyl or arylsulfonyl;Y is halogen, amino, monoalkyl- or monoaralkylamino, dialkylamino, aminomethyl, hydroxymethyl, lower alkyl, aryl, aralkyl, vinyl and substituted vinyl or ethynyl and substituted ethynyl;Z is methyne or nitrogen;R.sup.1 and R.sup.2 are the same or different and are hydrogen acyl or aroyl,in a veterinarianically acceptable carrier.

Abstract: Pyrimidine nucleosides exhibiting anti-viral and anti-tumor effects have the formula ##STR1## wherein A is OR.sup.3, SR.sup.3, NR.sup.3 R.sup.4 or NHacyl wherein R.sup.3 and R.sup.4 are the same or different and are hydrogen, lower alkyl of 1 to 7 carbon atoms, aralkyl, or aryl;NHacyl is alkanoyl or aroyl amide;B is oxygen or sulfur;X is halogen, alkylsulfonyl or arylsulfonyl;Y is halogen, amino, monoalkyl- or monoaralkylamino, dialkylamino, aminomethyl, hydroxymethyl, lower alkyl, aryl, aralkyl, vinyl and substituted vinyl or ethynyl and substituted ethynyl;Z is methyne or nitrogen;R.sup.1 and R.sup.2 are the same or different and are hydrogen acyl or aroyl.

Abstract: There is provided a novel process for pyrimidine to pyrimidine transformations by the displacement of the 1,2,3-portion of a pyrimidine by a 1,3-ambident nucleophile. The novel process requires that the 1 and 3 nitrogens of the pyrimidine moiety be substituted. The novel process makes available, inter alia, novel uracils, simple methods of radioisotopically labeling pyrimidine nuclei, a simple and inexpensive method of preparing the important antiviral and antileukemic material pseudoisocytidine and its new active analog 2'-deoxypseudoisocytidine.

Abstract: Pseudo-isocytidine is disclosed as well as methods and intermediates useful in its preparation. The novel compound pseudo-isocytidine, preferably the beta-anomer thereof, is an active cytostatic and anti-leukemic agent.