Abstract: A 2-phenylmorpholin-5-one derivative having the formula (I): wherein R1 represents a C1 to C8 alkyl group, a C3 to C7 cycloalkyl group or an indanyl group, R2 represents a C1 to C4 alkyl group, R3 represents a hydrogen atom, a C1 to C5 alkyl group, etc., R4 represents a hydrogen atom, a C1 to C6 alkyl group, etc., R5, R6 represent a hydrogen atom, a C1 to C5 alkyl group, etc., an optical isomer thereof or a pharmacologically acceptable salt thereof, or a hydrate or solvate thereof and a pharmaceutical composition containing the same. The above compound has a strong type IV phosphodiesterase (PDE) inhibitory activity and has bronchodilater and antiinflammatory effects.

Abstract: A 6-phenyltetrahydro-1,3-oxazin-2-one derivative having the formula (I): wherein, R1 is an unsubstituted or substituted C1 to C8 alkyl group; an unsubstituted or substituted C3 to C7 cycloalkyl group;, etc., R2 is a C1 to C4 alkyl group, R3 is H; an unsubstituted or substituted C1 to C5 alkyl group; etc., R4 is H; an unsubstituted or substituted C1 to C6 alkyl group, and R5 and R6 are independently a hydrogen atom; an unsubstituted or substituted C1 to C5 alkyl group; etc. an optical isomer thereof, or a pharmacologically acceptable salt thereof, or a hydrate or a solvate thereof and pharmaceutical compositions containing the same, in particular a drug for the prevention or treatment of inflammatory diseases and a drug for asthma. The above 6-phenyltetrahydro-1,3-oxazin-2-one derivative has a strong type IV PDE inhibitory activity and has a bronchiodilator and antiinflammatory effects.

Abstract: A 3-anilino-2-cycloalkenone derivative of the formula (I): wherein, R1 represents a C1 to C8 alkyl group, which may have a substituent, except for a methyl group, a C3 to C7 cycloalkyl group, a 3-tetrahydrofuryl group, an 2-indanyl group, etc., R2 represents a C1 to C4 alkyl group, R3 represents a hydrogen atom, a C3 to C7 alkyl group, which may have a substituent, a C3 to C7 cycloalkyl group, etc., R4 represents a hydrogen atom, a C1 to C5 alkyl group, which may have a substituent, a halogen atom, etc., R5, R6, R7, and R8 independently represent a hydrogen atom, a C1 to C5 alkyl group, which may have a substituent, etc., X represents —(CR11R12)n—, wherein n is 0 to 2, R11 and R12 independently represent a hydrogen atom, a C1 to C5 alkyl group, which may have a substituent, etc.

Abstract: A 5-phenyl-3-pyridazinone derivative having the formula (I) wherein R1 represents an unsubstituted or substituted C1 to C8 alkyl group, C3 to C7 cycloalkyl group, or indanyl group; R2 represents a C1 to C4 alkyl group; R3 represents a hydrogen atom or an unsubstituted or substituted C1 to C5 alkyl group; a C3 to C7 cycloalkyl group; or an aryl group which may contain a heteroatom; R4 and R5 independently represent a hydrogen atom, C1 to C6 alkyl group, an unsubstituted or substituted phenyl, or a monocyclic aryl group which may contain a heteroatom; a dotted line represents a single or double bond, provided that when the dotted line represents a single bond; R6 represents a hydrogen atom or C1 to C6 alkyl group.

Abstract: A laser beam machining method includes emitting light from a light source to illuminate a mask which has both openings through which light can pass to the object to be machined and blocking parts through which substantially no light can pass. By utilizing the energy of the light, those portions of the object which are exposed through the openings are machined by ablation. The shape and width of both the openings and the blocking parts can be adjusted so as to provide the energy distribution required to form an object of the desired shape and size.

Abstract: A magnetic disk includes two kinds of texture lines formed on a substrate rendered to texturing, one kind being formed over the entire substrate and parallel with a circumference of the substrate and the other kind being formed such that a line tangent to the other texture intersects a line tangent to the one texture at an angle of 3 to 9 degrees. The other texture lines are yielded by processing the substrate with a polishing tape rocking the substrate radially thereof, and satisfying the floating characteristic of a magnetic head as being floated in a low degree, the contact-start-stop characteristic, and the attraction characteristic.

Abstract: A vertical magnetic recording medium comprises a non-magnetic substrate, a permalloy film consisting of plural permalloy layers separated by at least one non-magnetic layer placed therein, each of said plurality of permalloy layers being 2000 .ANG. or less thick, and a Co-Cr vertical magnetization film formed on the permalloy film directly or through another non-magnetic layer.