Patents by Inventor Kyoko KAWAMOTO

Kyoko KAWAMOTO has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11649311
    Abstract: There is provided a method for introducing a temperature-sensitive probe comprising a copolymer, which comprises a thermoresponsive unit and a fluorescent unit, into a cell, and the method using the copolymer further comprising a cationic unit as the temperature-sensitive probe, and the method comprising the step of mixing the copolymer with the cell in a solvent. The copolymer can be preferably used as a fluorescence temperature sensor which measures intracellular temperature since the copolymer has a cationic group and thus enters into a cell without using a special method.
    Type: Grant
    Filed: December 13, 2018
    Date of Patent: May 16, 2023
    Assignees: KIRIN HOLDINGS KABUSHIKI KAISHA, THE UNIVERSITY OF TOKYO
    Inventors: Toshikazu Tsuji, Kumiko Ikado, Seiichi Uchiyama, Kyoko Kawamoto
  • Patent number: 11452697
    Abstract: An intracellular delivery vehicle of which surface is covered by a positive charge, an intracellular delivery complex in which a component or compound desired is loaded in the intracellular delivery vehicle, a temperature-sensitive probe comprising the intracellular delivery complex, and a method for measuring the intracellular temperature by the temperature-sensitive probe are disclosed. The intracellular delivery vehicle is useful on account of its capability of easily delivering the component or compound desired inside the cell without inhibiting cell proliferation.
    Type: Grant
    Filed: June 12, 2020
    Date of Patent: September 27, 2022
    Assignees: KIRIN HOLDINGS KABUSHIKI KAISHA, THE UNIVERSITY OF TOKYO, TOHOKU UNIVERSITY
    Inventors: Toshikazu Tsuji, Kumiko Ikado, Sayuri Yamada, Seiichi Uchiyama, Kyoko Kawamoto, Hidetoshi Tokuyama, Kentaro Okano
  • Patent number: 11199537
    Abstract: There is provided a method for introducing a temperature-sensitive probe comprising a copolymer, which comprises a thermoresponsive unit and a fluorescent unit, into a cell, and the method using the copolymer further comprising a cationic unit as the temperature-sensitive probe, and the method comprising the step of mixing the copolymer with the cell in a solvent. The copolymer can be preferably used as a fluorescence temperature sensor which measures intracellular temperature since the copolymer has a cationic group and thus enters into a cell without using a special method.
    Type: Grant
    Filed: December 13, 2018
    Date of Patent: December 14, 2021
    Assignees: KIRIN HOLDINGS KABUSHIKI KAISHA, THE UNIVERSITY OF TOKYO
    Inventors: Toshikazu Tsuji, Kumiko Ikado, Seiichi Uchiyama, Kyoko Kawamoto
  • Publication number: 20200309782
    Abstract: An intracellular delivery vehicle of which surface is covered by a positive charge, an intracellular delivery complex in which a component or compound desired is loaded in the intracellular delivery vehicle, a temperature-sensitive probe comprising the intracellular delivery complex, and a method for measuring the intracellular temperature by the temperature-sensitive probe are disclosed. The intracellular delivery vehicle is useful on account of its capability of easily delivering the component or compound desired inside the cell without inhibiting cell proliferation.
    Type: Application
    Filed: June 12, 2020
    Publication date: October 1, 2020
    Applicants: KIRIN HOLDINGS KABUSHIKI KAISHA, THE UNIVERSITY OF TOKYO, TOHOKU UNIVERSITY
    Inventors: Toshikazu Tsuji, Kumiko Ikado, Sayuri Yamada, Seiichi Uchiyama, Kyoko Kawamoto, Hidetoshi Tokuyama, Kentaro Okano
  • Patent number: 10712346
    Abstract: An intracellular delivery vehicle of which surface is covered by a positive charge, an intracellular delivery complex in which a component or compound desired is loaded in the intracellular delivery vehicle, a temperature-sensitive probe comprising the intracellular delivery complex, and a method for measuring the intracellular temperature by the temperature-sensitive probe are disclosed. The intracellular delivery vehicle is useful on account of its capability of easily delivering the component or compound desired inside the cell without inhibiting cell proliferation.
    Type: Grant
    Filed: September 6, 2016
    Date of Patent: July 14, 2020
    Assignees: KIRIN HOLDINGS KABUSHIKI KAISHA, THE UNIVERSITY OF TOKYO, TOHOKU UNIVERSITY
    Inventors: Toshikazu Tsuji, Kumiko Ikado, Sayuri Yamada, Seiichi Uchiyama, Kyoko Kawamoto, Hidetoshi Tokuyama, Kentaro Okano
  • Publication number: 20190137503
    Abstract: An intracellular delivery vehicle of which surface is covered by a positive charge, an intracellular delivery complex in which a component or compound desired is loaded in the intracellular delivery vehicle, a temperature-sensitive probe comprising the intracellular delivery complex, and a method for measuring the intracellular temperature by the temperature-sensitive probe are disclosed. The intracellular delivery vehicle is useful on account of its capability of easily delivering the component or compound desired inside the cell without inhibiting cell proliferation.
    Type: Application
    Filed: September 6, 2016
    Publication date: May 9, 2019
    Applicants: KIRIN KABUSHIKI KAISHA, THE UNIVERSITY OF TOKYO, TOHOKU UNIVERSITY
    Inventors: Toshikazu TSUJI, Kumiko IKADO, Sayuri YAMADA, Seiichi UCHIYAMA, Kyoko KAWAMOTO, Hidetoshi TOKUYAMA, Kentaro OKANO
  • Publication number: 20190128874
    Abstract: There is provided a method for introducing a temperature-sensitive probe comprising a copolymer, which comprises a thermoresponsive unit and a fluorescent unit, into a cell, and the method using the copolymer further comprising a cationic unit as the temperature-sensitive probe, and the method comprising the step of mixing the copolymer with the cell in a solvent. The copolymer can be preferably used as a fluorescence temperature sensor which measures intracellular temperature since the copolymer has a cationic group and thus enters into a cell without using a special method.
    Type: Application
    Filed: December 13, 2018
    Publication date: May 2, 2019
    Applicants: KIRIN HOLDINGS KABUSHIKI KAISHA, THE UNIVERSITY OF TOKYO
    Inventors: Toshikazu TSUJI, Kumiko IKADO, Seiichi UCHIYAMA, Kyoko KAWAMOTO
  • Publication number: 20190113505
    Abstract: There is provided a method for introducing a temperature-sensitive probe comprising a copolymer, which comprises a thermoresponsive unit and a fluorescent unit, into a cell, and the method using the copolymer further comprising a cationic unit as the temperature-sensitive probe, and the method comprising the step of mixing the copolymer with the cell in a solvent. The copolymer can be preferably used as a fluorescence temperature sensor which measures intracellular temperature since the copolymer has a cationic group and thus enters into a cell without using a special method.
    Type: Application
    Filed: December 13, 2018
    Publication date: April 18, 2019
    Applicants: KIRIN HOLDINGS KABUSHIKI KAISHA, THE UNIVERSITY OF TOKYO
    Inventors: Toshikazu TSUJI, Kumiko IKADO, Seiichi UCHIYAMA, Kyoko KAWAMOTO
  • Patent number: 10191035
    Abstract: There is provided a method for introducing a temperature-sensitive probe comprising a copolymer, which comprises a thermoresponsive unit and a fluorescent unit, into a cell, and the method using the copolymer further comprising a cationic unit as the temperature-sensitive probe, and the method comprising the step of mixing the copolymer with the cell in a solvent. The copolymer can be preferably used as a fluorescence temperature sensor which measures intracellular temperature since the copolymer has a cationic group and thus enters into a cell without using a special method.
    Type: Grant
    Filed: May 20, 2014
    Date of Patent: January 29, 2019
    Assignees: KIRIN HOLDINGS KABUSHIKI KAISHA, THE UNIVERSITY OF TOKYO
    Inventors: Toshikazu Tsuji, Kumiko Ikado, Seiichi Uchiyama, Kyoko Kawamoto
  • Publication number: 20140342390
    Abstract: There is provided a method for introducing a temperature-sensitive probe comprising a copolymer, which comprises a thermoresponsive unit and a fluorescent unit, into a cell, and the method using the copolymer further comprising a cationic unit as the temperature-sensitive probe, and the method comprising the step of mixing the copolymer with the cell in a solvent. The copolymer can be preferably used as a fluorescence temperature sensor which measures intracellular temperature since the copolymer has a cationic group and thus enters into a cell without using a special method.
    Type: Application
    Filed: May 20, 2014
    Publication date: November 20, 2014
    Applicants: THE UNIVERSITY OF TOKYO, KIRIN HOLDINGS KABUSHIKI KAISHA
    Inventors: Toshikazu TSUJI, Kumiko IKADO, Seiichi UCHIYAMA, Kyoko KAWAMOTO