Abstract: A calculating device of the stiffness measurement device pressurizes an object to be measured with a predetermined pressure and the stiffness of the object to be measured in the squeal frequency band is calculated based on an inclination of a stress-displacement performance curve immediately after a start of depressurization after the pressurization. According to this device, there is no need to oscillate the object with a high frequency band and there is no need to enhance the stiffness of the housing of the measurement device, which leads to a downsizing of the device. Further, there is no need for measuring of acceleration speed of the object to be measured and accelerator can be eliminated to reduce the cost of the stiffness measurement device.

Abstract: A calculating device of the stiffness measurement device pressurizes an object to be measured with a predetermined pressure and the stiffness of the object to be measured in the squeal frequency band is calculated based on an inclination of a stress-displacement performance curve immediately after a start of depressurization after the pressurization. According to this device, there is no need to oscillate the object with a high frequency band and there is no need to enhance the stiffness of the housing of the measurement device, which leads to a downsizing of the device. Further, there is no need for measuring of acceleration speed of the object to be measured and accelerator can be eliminated to reduce the cost of the stiffness measurement device.

Abstract: Provided are a mast cell degranulation control agent, a diagnostic agent or therapeutic agent for a disease resulting from mast cell degranulation control, a method of controlling mast cell degranulation, and a screening method for a mast cell degranulation control agent, all of which involve the use of a nucleic acid and the like. These are useful in the diagnosis or treatment of a disease resulting from mast cell degranulation control.

Abstract: According to the present invention, it possible to provide a novel nucleic acid, a vector that expresses the nucleic acid, a screening method for a substance that controls the nucleic acid, a method of detecting the expression and a mutation of the nucleic acid, and a diagnostic method or therapeutic method for a disease caused by an abnormality of mesenchymal stem cells, mast cells or the like, or a disease caused by a cell proliferation abnormality, such as cancer.

Abstract: The present invention provides a nucleic acid such as a micro-RNA or a micro-RNA precursor, having a novel sequence. The nucleic acid of the present invention is useful for detecting the expression or a mutation of a micro-RNA, separating cells, suppressing the expression of a gene having a target sequence, screening for a substance that promotes or suppresses a function of a micro-RNA, and diagnosing or treating a disease caused by a mast cell abnormality, a disease caused by an abnormality of mesenchymal stem cell proliferation or differentiation, cancers, and a disease caused by abnormal proliferation of cells, tissue hyperplasia or the like.