Abstract: Provided is a method for producing effector cells expressing a desired specificity determining region. In this method, material cells that have a cassette deck structure with a cassette tape gene comprising a gene encoding a marker protein in their genome, wherein the material cells can be differentiated into the effector cells, and wherein the marker protein can be expressed in the effector cells or progenitor cells thereof when the material cells are differentiated into the effector cells or progenitor cells thereof are provided first. The material cells are proliferated, the proliferated cells are differentiated into the effector cells, and then, the gene encoding the marker protein in the effector cells is exchanged with a gene encoding a protein that contribute the desired specificity.

Abstract: Provided is an image processing apparatus that enhances the distinctiveness of document having a color portion and outputs in monochrome. A monochrome visual determination unit determines whether or not the distinctiveness of the color portion is low when the document data having the color portion is output in monochrome. This color portion includes characters, electronic marks, and graphs, and they are after a specific keyword. A monochrome presentation unit presents to a user a warning or a result of modification when there is the color portion that the distinctiveness is determined to be low by the monochrome visual determination unit. The monochrome presentation unit presents a state in which the document data is output in monochrome by displaying a preview.

Abstract: Provided is a method for inducing CD4?CD8+ T cells having an antigen specific cytotoxic activity from pluripotent stem cells, comprising the steps of: (1) differentiating pluripotent stem cells to give a cell culture comprising CD4?CD8? T cells and CD4+CD8+ T cells, (2) removing CD4?CD8? cells from the cell culture obtained in step (1), and (3) differentiating the CD4+CD8+ cells in the cell culture into CD4?CD8+ T cells.

Abstract: Provided is an image processing apparatus that enhances the distinctiveness of document having a color portion and outputs in monochrome. A monochrome visual determination unit determines whether or not the distinctiveness of the color portion is low when the document data having the color portion is output in monochrome. This color portion includes characters, electronic marks, and graphs, and they are after a specific keyword. A monochrome presentation unit presents to a user a warning or a result of modification when there is the color portion that the distinctiveness is determined to be low by the monochrome visual determination unit. The monochrome presentation unit presents a state in which the document data is output in monochrome by displaying a preview.

Abstract: Provided is a method for inducing CD4?CD8+ T cells having an antigen specific cytotoxic activity from pluripotent stem cells, comprising the steps of: (1) differentiating pluripotent stem cells to give a cell culture comprising CD4?CD8? T cells and CD4+CD8+ T cells, (2) removing CD4?CD8? cells from the cell culture obtained in step (1), and (3) differentiating the CD4+CD8+ cells in the cell culture into CD4?CD8+ T cells.

Abstract: Provided is a method for producing a cell incorporating an antigen specific receptor gene, which comprises the step of introducing an exogenous TCR or CAR gene into a material cell so that the introduced gene is expressed under the T cell receptor expression control system of the material cell.

Abstract: Provided is a method for producing regulatory T cells for inducing immune tolerance in a subject. The method comprises the step of co-culturing regulatory T cells obtained from the subject with dendritic cells derived from iPS cells.

Abstract: A construction machine includes: a partition member partitioning an accommodation space in an engine compartment into a main chamber and an intake chamber while having an inter-chamber opening; a fan disposed in the main chamber to generate cooling air flowing through an air intake opening, the intake chamber, the inter-chamber opening, and the main chamber in this order by sucking air in the engine compartment in a suction direction; a duct joined to an outer wall to enclose the air intake opening and including an inner peripheral surface enclosing a duct passage leading to the air intake opening and an outer peripheral surface. The duct extends in a duct extension direction different from the suction direction of the fan, disposed in the intake chamber to define a duct surrounding space around the outer peripheral surface of the duct.

Abstract: Provided is a method for inducing CD4?CD8+ T cells having an antigen specific cytotoxic activity from pluripotent stem cells, comprising the steps of: (1) differentiating pluripotent stem cells to give a cell culture comprising CD4?CD8? T cells and CD4+CD8+ T cells, (2) removing CD4?CD8? cells from the cell culture obtained in step (1), and (3) differentiating the CD4+CD8+ cells in the cell culture into CD4?CD8+ T cells.

Abstract: Provided is a method for preparing cultured cells or tissues for transplantation, comprising at least one of the following steps 1) and 2): 1) when the cultured cells or tissues do not express an HLA-C molecule of at least one HLA-C groups expressed in the receipient's HLA-C locus, forcing the expression of an HLA-C molecule of said HLA-C group in the cultured cells or tissues, or 2) when the cultured cells or tissues are negative or weakly positive for HLA-Bw4 while the recipient is positive for HLA-Bw4, forcing the expression of an HLA molecule of HLA-Bw4 group in the cultured cells or tissues.

Abstract: Identifying unit identifies a character selected by a user from among plural characters in a terminal, through communication with the terminal via communication unit. Comparison unit, when a first character is identified by identifying unit, compares a history of selections of the first character and a history of selections of a second character with reference to history database. Output unit outputs expression data based on a result of the comparison by comparison unit with reference to expression database, which data represents an expression used when the first character interacts with the user.

Abstract: Provided is a construction machine capable of smooth exhaust and suppression of a leak of noise from an engine room, including an engine guard defining an engine room, a cooling fan disposed in the engine room, a projection element projecting upward beyond the engine guard, and an exhaust duct. The exhaust duct has a bent shape including a first duct section extending along an axial flow direction of the cooling fan from an upstream end portion surrounding a duct inlet to a connection portion and a second duct section extending upward from the connection portion and surrounding a duct outlet opened upward, also including an engine concealment section obstructing a direct view to an engine through the duct outlet from outside the engine room.

Abstract: A construction machine includes: a partition member partitioning an accommodation space in an engine compartment into a main chamber and an intake chamber while having an inter-chamber opening; a fan disposed in the main chamber to generate cooling air flowing through an air intake opening, the intake chamber, the inter-chamber opening, and the main chamber in this order by sucking air in the engine compartment in a suction direction; a duct joined to an outer wall to enclose the air intake opening and including an inner peripheral surface enclosing a duct passage leading to the air intake opening and an outer peripheral surface. The duct extends in a duct extension direction different from the suction direction of the fan, disposed in the intake chamber to define a duct surrounding space around the outer peripheral surface of the duct.

Abstract: Provided is a method for inducing T cells for a cell-based immunotherapy, comprising the steps of: (1) providing Rag 1 and/or Rag 2 gene knockout human pluripotent stem cells bearing genes encoding a T cell receptor specific for a desired antigen, and (2) inducing T cells from the pluripotent stem cells of step (1). Further provided are a cell-based immunotherapy method that uses the T cells for the cell-based immunotherapy and an iPS cell bank for the cell-based immunotherapy.

Abstract: Provided is a construction machine capable of smooth exhaust and suppression of a leak of noise from an engine room, including an engine guard defining an engine room, a cooling fan disposed in the engine room, a projection element projecting upward beyond the engine guard, and an exhaust duct. The exhaust duct has a bent shape including a first duct section extending along an axial flow direction of the cooling fan from an upstream end portion surrounding a duct inlet to a connection portion and a second duct section extending upward from the connection portion and surrounding a duct outlet opened upward, also including an engine concealment section obstructing a direct view to an engine through the duct outlet from outside the engine room.

Abstract: Identifying unit identifies a character selected by a user from among plural characters in a terminal, through communication with the terminal via communication unit. Comparison unit, when a first character is identified by identifying unit, compares a history of selections of the first character and a history of selections of a second character with reference to history database. Output unit outputs expression data based on a result of the comparison by comparison unit with reference to expression database, which data represents an expression used when the first character interacts with the user.

Abstract: A hydraulic tubing support that reduces noise transmitted to an operator due to pulsation of hydraulic oil in a junction tube. The hydraulic tubing support structure includes a pair of left and right remote control valves for generating pilot pressures for the plurality of hydraulic actuators in response to an input operation performed on each operating lever, pump-side tubes and tank-side tubes respectively extending from the respective remote control valves, a junction tube for allowing communication of the tubes guided to below a floor plate through a through hole and communication of the tubes guided to below the floor plate through a through hole, and a middle reinforcement beam extending in a right-and-left direction and fixed to the lower surface of the floor plate. The junction tube is fixed to the middle reinforcement beam in a non-contact state with the floor plate.

Abstract: According to the invention, there is provided a damping structure capable of obtaining a sufficient damping effect even against vibrations of small amplitudes, by promoting movements of powder/particle materials inside a hollow body. In the damping structure of the invention, a damping member 2 is provided on a structure 1 to be damped. The damping member 2 includes a hollow body 5 which is filled with powder/particle materials 3, partially leaving a space 4. A vibration wall face part 7 which vibrates more violently than the structure 1, on receiving vibration, is formed in at least a part of wall face parts 6 of the hollow body 5. The vibration wall face part 7 is preferably formed of a material having a lower elastic modulus and/or a lower density than the other parts.

Abstract: Speech data acquiring unit acquires speech data representing a user's speech. Text data acquiring unit acquires text data generated as a result of a speech recognition processing based on the speech data. Operation identifying unit identifies an operation represented by text data. Schedule data identifying unit, when the identified operation is not an operation for requesting starting a phone conversation in response to an incoming call, identifies schedule data. Reply date/time identifying unit identifies a date and time when a reply will be made to the received call, based on schedule data. Response sentence data generating unit generates voice data of a response sentence indicating that a reply will be made on the identified date and time. Response sentence data sending unit sends the voice data of a response sentence to a communication device of a caller.

Abstract: A construction machine capable of effectively reducing noise which would intrude into a cab, without deterioration in ride quality, comfort and air-conditioning efficiency in the cab is provided. The construction machine includes a lower propelling body, an upper slewing body including an upper frame, a cab including a floor plate and installed on the upper frame, and a cab noise reduction device. The cab noise reduction device includes: the floor plate; an under-cab member including a cab deck supporting the cab and provided under the cab to define a closed-form under-cab space whose periphery is substantially closed, in cooperation with the floor plate; and a resonator reducing noise in the under-cab space by a resonance effect.