Abstract: An endoscope light source apparatus includes a turret provided with a first optical filter and a second optical filter for transmitting an illuminating light, an instruction section in which an operation instruction of the turret is inputted, a drive section that drives the turret, a first detector that detects a position of the turret, a first detected portion for identifying a position of the first optical filter, a second detected portion for identifying a position of the second optical filter, a second detector that optically detects a position of the first or the second detected portion, and a turret control section that outputs a drive signal to the drive section to move the turret until the first or the second detected portion is detected by the second detector and stop the turret in response to the first or the second detected portion being detected.

Abstract: An endoscope light source apparatus includes a turret provided with a first optical filter and a second optical filter for transmitting an illuminating light, an instruction section in which an operation instruction of the turret is inputted, a drive section that drives the turret, a first detector that detects a position of the turret, a first detected portion for identifying a position of the first optical filter, a second detected portion for identifying a position of the second optical filter, a second detector that optically detects a position of the first or the second detected portion, and a turret control section that outputs a drive signal to the drive section to move the turret until the first or the second detected portion is detected by the second detector and stop the turret in response to the first or the second detected portion being detected.

Abstract: A light source apparatus includes a first light-emitting element to generate an illumination light with a first light emission intensity to be applied to a subject, and a second light-emitting element to generate an illumination light with a second light emission intensity, including at least light with a wavelength different from the illumination light generated from the first light-emitting element. The first light-emitting element and second light-emitting element are arranged, so that the peaks of the first emission intensity and second emission intensity become identical.

Abstract: A light source apparatus capable of controlling a quantity of light in a stable manner and an endoscope apparatus including the light source apparatus are provided. The light source apparatus includes a light source and a light quantity adjusting portion for limiting the light flux from the light source using an aperture blade. The light quantity adjusting portion includes the aperture blade which is driven to rotate in a vertical plane about a pivot and has a center of gravity which is decentered from the pivot, a position detecting portion for detecting a position of the aperture blade, a driving portion, and a light source controlling portion for controlling the driving portion. The light source controlling portion controls the driving portion based on the position of the aperture blade and a rotation direction.

Abstract: A light source device includes a light-condensing device that condenses an illumination light that is emitted from a light source lamp. The light-condensing device includes at least one lens, a lens holder in which a lens is fixedly provided, and a lens holding member. The lens holding member is a member for fixing a lens to the lens holder. The lens holding member causes at least one circumferential portion of the lens to protrude to the lens holder side, and causes the optical axis of the lens to match the optical axis of the illumination light.

Abstract: A light source device which causes a sufficiently bright subject image to be obtained is provided. The light source device includes a first light-emitting diode 10-1 which generates illumination light to be applied to a subject, a second light-emitting diode 10-2 which generates illumination light with wavelength different from the illumination light generated from the first light-emitting diode 10-1, and a light-emitting diode drive control section 3 which independently controls integrated output values (light emission intensities, light emission periods) of the first light-emitting diode 10-1 and second light-emitting diode 10-2 in synchronism with image pickup timing at which the subject is photographed.

Abstract: A light source device includes a light source lamp, a rotary plate, a heat absorbing portion, and a filter mounting member. The light source lamp emits illumination light. The rotary plate includes multiple opening portions that are selectively disposed in the illumination light path of the light source lamp. A reflective filter that reflects light of a wavelength that acts a heat source in illumination light is provided in one of the multiple opening portions of the rotary plate. The heat absorbing portion absorbs heat included in reflected light reflected by the reflective filter in the opening portion. The filter mounting member disposes the reflective filter in the opening portion at a predetermined angle of inclination to the optical axis of the illumination light. By disposing the inclined reflective filter in the illumination light path, reflected light reflected by the reflective filter is reflected towards the heat absorbing portion.

Abstract: The present invention provides a recombinant virus which is efficacious and highly safe in preventing the onset of SARS infection and a vaccine for SARS coronavirus containing the same. The recombinant virus of the invention can express a SARS coronavirus gene.

Abstract: A light source apparatus capable of controlling a quantity of light in a stable manner and an endoscope apparatus including the light source apparatus are provided. The light source apparatus includes a light source and a light quantity adjusting portion for limiting the light flux from the light source using an aperture blade. The light quantity adjusting portion includes the aperture blade which is driven to rotate in a vertical plane about a pivot and has a center of gravity which is decentered from the pivot, a position detecting portion for detecting a position of the aperture blade, a driving portion, and a light source controlling portion for controlling the driving portion. The light source controlling portion controls the driving portion based on the position of the aperture blade and a rotation direction.

Abstract: A light source device which causes a sufficiently bright subject image to be obtained is provided. The light source device includes a first light-emitting diode 10-1 which generates illumination light to be applied to a subject, a second light-emitting diode 10-2 which generates illumination light with wavelength different from the illumination light generated from the first light-emitting diode 10-1, and a light-emitting diode drive control section 3 which independently controls integrated output values (light emission intensities, light emission periods) of the first light-emitting diode 10-1 and second light-emitting diode 10-2 in synchronism with image pickup timing at which the subject is photographed.

Abstract: A light source device includes a light source lamp, a rotary plate, a heat absorbing portion, and a filter mounting member. The light source lamp emits illumination light. The rotary plate includes multiple opening portions that are selectively disposed in the illumination light path of the light source lamp. A reflective filter that reflects light of a wavelength that acts a heat source in illumination light is provided in one of the multiple opening portions of the rotary plate. The heat absorbing portion absorbs heat included in reflected light reflected by the reflective filter in the opening portion. The filter mounting member disposes the reflective filter in the opening portion at a predetermined angle of inclination to the optical axis of the illumination light. By disposing the inclined reflective filter in the illumination light path, reflected light reflected by the reflective filter is reflected towards the heat absorbing portion.

Abstract: A light source device includes a light-condensing device that condenses an illumination light that is emitted from a light source lamp. The light-condensing device includes at least one lens, a lens holder in which a lens is fixedly provided, and a lens holding member. The lens holding member is a member for fixing a lens to the lens holder. The lens holding member causes at least one circumferential portion of the lens to protrude to the lens holder side, and causes the optical axis of the lens to match the optical axis of the illumination light.

Abstract: A light source device includes a light source, a diaphragm blade for adjusting light quantity of illumination light supplied from the light source, a diaphragm driving part for driving the diaphragm blade to perform opening/closing operation, and a diaphragm control circuit part for setting diaphragm drive instruction voltage to be supplied to the diaphragm driving part and control an opening/closing amount of the diaphragm blade. In the diaphragm control circuit part, a fully-opened voltage and a fully-closed voltage at the time the diaphragm blade is fixed at a fully-opened position and a fully-closed position are read, based on the voltages, adjustment data for adjusting the diaphragm drive instruction voltage and the opening/closing positions of the diaphragm blade is set, and based on the adjustment data, a control range of the diaphragm drive instruction voltage is regulated.

Abstract: A light source apparatus includes a first light-emitting element to generate an illumination light with a first light emission intensity to be applied to a subject, and a second light-emitting element to generate an illumination light with a second light emission intensity, including at least light with a wavelength different from the illumination light generated from the first light-emitting element. The first light-emitting element and second light-emitting element are arranged, so that the peaks of the first emission intensity and second emission intensity become identical.

Abstract: An endoscopic apparatus having an image pickup system operating as follows. Before picking up a still image in a body cavity that almost no light can reach, the system extinguishes LED and resets charges accumulated in respective pixels in a CMOS image sensor. In this reset state, the system illuminates LED and allows the CMOS image sensor to pick up a still image. While the charges are being read from the pixels, the system extinguishes LED and prevents further charges from being accumulated in the pixels from which the charges have not been read yet.

Abstract: A hepatitis A, B-combined adjuvanted vaccine is disclosed in this application, said vaccine comprising an inactivated hepatitis A virus antigen, a hepatitis B virus surface antigen and an adjuvant. The present vaccine is obtained by causing the antigens to be adsorbed to the adjuvant. According to the present invention, the infection associated with hepatitis A virus and with hepatitis B virus can be prevented without causing any interference due to the mixing of these antigens and any severe side-effects, and the anti-hepatitis A virus antibody titer is greatly enhanced by the mixing.

Abstract: Lyophilized preparation of hepartitis B vaccine, which comprises a purified hepatitis B virus surface antigen produced by a recombinant organism being capable of producing HBs antigen, which is adsorbed on aluminum gel in the lyophilized state in the presence of a stabilizer, said lyophilized preparation being prepared by the steps of adding an aluminum gel and a stabilizer to a purified recombinant-origin HBs antigen and lyophilizing the mixture. Said lyophilized preparation being able to be stably kept for a long period of time without losing its antigen titer and being useful for the prophylaxis of infection of hepatitis B virus.

Abstract: An improved method for the purification of hepatitis B virus surface anti by column chromatography, which is characteristic in using as a gel for the chromatography a sulfuric acid ester of a crosslinked polysaccharide or cellulose which is obtained by sulfating a crosslinked polysaccharide or cellulose. Said method can give a highly purified hepatitis B virus surface antigen which is useful for the preparation of hepatitis B virus vaccine.

Abstract: An improved method for purification of HBs antigen comprising passing a partially purified HBs antigen prepared from blood plasma or serum through a column filled with an anion exchanger which may be equilibrated with a buffer solution having a specific ionic strength and pH level, and further passing the resulting effluent through a column filled with a cation exchanger which may be equilibrated with a buffer solution having a specific ionic strength and pH level. The HBs antigen obtained by the present invention is highly purified and is useful for preparing vaccine for preventing Viral Hepatitis Type B.