Abstract: Disclosed are an artificial esophageal structure having a multi-layer structure using three-dimensional bio-printing, and a manufacturing device and manufacturing method therefor. The artificial esophageal structure having a multi-layer structure according to one embodiment of the present invention comprises: a first layer in the shape of a hollow column and having a circular cross section; a second layer which is disposed inside the first layer and which is a column structure that simulates the mucosal layer of the esophagus; and an interlayer support part which is disposed between the first layer and the second layer and which maintains a gap between the layers, wherein the first layer and second layer each comprise: a plurality of column parts disposed at predetermined intervals; and a plurality of strands formed between the plurality of column parts by a dragging technique, and may have a porous structure due to pores between the plurality of strands.

Abstract: A microdroplet or microparticle with Janus or core-shell internal morphology, which is obtained under the control of phase separation of high-concentration NIPAAm formed at 25° C. or more in a microfluidic device, is provided. The microdroplet or microparticle shows an anisotropic volume change according to a change in temperature, and can also serve as a fat-soluble/water-soluble carrier, and thus can be used as a new material for medical supplies in the field of various applications in the future.

Abstract: A microdroplet or microparticle with Janus or core-shell internal morphology, which is obtained under the control of phase separation of high-concentration NIPAAm formed at 25° C. or more in a microfluidic device, is provided. The microdroplet or microparticle shows an anisotropic volume change according to a change in temperature, and can also serve as a fat-soluble/water-soluble carrier, and thus can be used as a new material for medical supplies in the field of various applications in the future.