Abstract: A compound is represented by Formula 1, a stereoisomer or a pharmaceutically acceptable salt thereof. The compound inhibits agmatinase and is expected to be helpful for improving autism spectrum disorder, emotional and behavioral disorder such as schizophrenia, as well as emotional and behavioral disorder-related symptoms such as lack of sociality, hyperactivity or the like.

Abstract: Disclosed are a carboxamide derivative and a pharmaceutical composition comprising same as an active ingredient for use in preventing or treating mental illness. The derivative is superbly effective in a triple reuptake inhibitor of serotonin, norepinephrine, and dopamine, and thus can be effectively used in treating mental illness.

Abstract: The present invention relates to a 5-membered heteroaryl derivative containing an N, and a pharmaceutical composition for use in preventing or treating mental disorders, containing same as an active ingredient, wherein the derivative is excellent in the triple reuptake inhibitory effect of serotonin, norepinephrine, and dopamine, and thus can be useful in the treatment of mental disorders.

Abstract: Disclosed are a sulfonamide derivative and a pharmaceutical composition comprising same as an active ingredient for use in preventing or treating mental illness. The derivative is superbly effective in a triple reuptake inhibitor of serotonin, norepinephrine, and dopamine, and thus can be effectively used in treating mental illness.

Abstract: The present invention provides a novel use of a Maydis stigma extract in prophylaxis, alleviation, or therapy of sleep disorder. A Maydis stigma extract has the effect of reducing sleep onset latency and increasing sleep duration, as high as or higher than the effect of ketamine or pentobarbital, which are conventionally used as soporifics. As a natural substance, the Maydis stigma extract does not cause side effects, such as cytotoxicity, resistance, or dependency, even when used for a long term.