Abstract: A semiconductor device includes a first active pattern that extends in a first horizontal direction, a second active pattern which extends in the first horizontal direction, and is spaced apart from the first active pattern by a first distance in a second horizontal direction, a third active pattern which extends in the first horizontal direction, and is spaced apart from the second active pattern by a second distance greater than the first distance in the second horizontal direction, a first gate electrode which extends in the second horizontal direction on the first to third active patterns, a second gate electrode which extends in the second horizontal direction on the first and second active patterns, and is spaced apart from the first gate electrode in the first horizontal direction, a first gate contact and a second gate contact which extends in the second horizontal direction on the second gate electrode.

Abstract: An integrated circuit layout includes: a first chip area; and a second chip area, wherein the first chip area includes: a first main area including a first main pattern; a first mark area adjacent to the first main area, wherein a first mark pattern is formed in the first mark area; and a first dummy area including a first dummy pattern, wherein the second chip area includes: a second main area including a second main pattern; a second mark area adjacent to the second main area, wherein a second mark pattern is formed in the second mark area; and a second dummy area including a second dummy pattern, wherein the first and second mark patterns are used to check alignment states of the first chip area and the second chip area, respectively, and wherein each of the first and second mark patterns has a standard cell structure.

Abstract: Provided are a hybrid supported catalyst which includes two or more kinds of transition metal compounds having the following Chemical Formulas 1 and 2, thereby preparing a polyolefin, particularly, a high-density polyethylene having a molecular structure which is optimized to improve tensile strength of a chlorinated polyolefin compound, and a method of preparing a polyolefin using the same: wherein all the variables are described herein.

Abstract: The present disclosure relates to an organic-inorganic hybrid polyolefin composite and a preparation method of the same.

Abstract: The present invention provides a PEGylated IFN-? variant and a composition for preventing or treating hyperproliferative diseases, inflammatory diseases, autoimmune diseases or viral infectious diseases, the composition comprising the PEGylated IFN-? variant as an effective ingredient. The PEGylated IFN-? variant of the present invention has an excellent anti-viral efficacy, immune regulatory function and anti-cell growth efficacy by virtue of better pharmacokinetic properties compared to native IFN-? and non-PEGylated IFN-? variants, and therefore can be used usefully against various diseases. The present invention provides good patient convenience in terms of administration due to exhibition of an excellent pharmacological activity effect upon administration and a significant increase of half-life in blood over existing interferon formulations.

Abstract: A tuning method for a clutch temperature estimation model may include, generating n tuning genes, calculating a tuning value corresponding to a tuning variable by using information of each of the n tuning genes, calculating a temperature estimation accuracy by applying the calculated tuning value to the clutch temperature estimation model, extracting n tuning genes of highest calculated accuracies, and regenerating m tuning genes through recombination of the extracted n tuning genes.

Abstract: A semiconductor device includes a first active pattern that extends in a first horizontal direction, a second active pattern which extends in the first horizontal direction, and is spaced apart from the first active pattern by a first distance in a second horizontal direction, a third active pattern which extends in the first horizontal direction, and is spaced apart from the second active pattern by a second distance greater than the first distance in the second horizontal direction, a first gate electrode which extends in the second horizontal direction on the first to third active patterns, a second gate electrode which extends in the second horizontal direction on the first and second active patterns, and is spaced apart from the first gate electrode in the first horizontal direction, a first gate contact and a second gate contact which extends in the second horizontal direction on the second gate electrode.

Abstract: A catalyst composition, a method from preparing an olefin polymer using the same, and an olefin polymer prepared from the same are disclosed herein. In some embodiments, a catalyst composition includes a first metallocene compound represented by the Chemical Formula 1, a second metallocene compound represented by the Chemical Formula 2, and a support. The catalyst composition can exhibit high activity in an olefin polymerization reaction and thus contribute to reducing catalyst costs, and can also exhibit high copolymerizability which can secure excellent processability and long-term physical properties, and thus, is suitable for providing polymers for pipes.

Abstract: The present disclosure relates to a polyethylene, which is reacted with chlorine to prepare a chlorinated polyethylene having excellent chlorination productivity and thermal stability by enabling an increase in chlorination temperature, and facilitating deoxidation, dehydration and drying processes during chlorination processing, by implementing an enlarged area of the middle and high molecular weight regions in the molecular structure of the polyethylene.

Abstract: The present invention provides: an antibody which specifically bonds to human NINJ-1; and a fragment thereof. The antibody or the fragment thereof according to the present invention has very high bonding affinity and bonding specificity with respect to a human NINJ-1 or a homogeneous binding site of the protein, and does not exhibit cross-reactivity with NINJ-1 proteins that are derived from other organisms and have high protein similarity. Accordingly, the present invention provides significant advantages with respect to accuracy and sensitivity and the like, not only in diagnosing disease related to NINJ-1 proteins but also in inhibiting pathological conditions involving NINJ-1 proteins. In particular, the antibody provided according to the present invention has a remarkable effect of inhibiting attachment between immunocytes and human cerebral endothelial cells, and thus has an effect of treating multiple sclerosis.

Abstract: Provided are a hybrid supported catalyst which includes two or more kinds of transition metal compounds having the following Chemical Formulas 1 and 2, thereby preparing a polyolefin, particularly, a high-density polyethylene having a molecular structure which is optimized to improve tensile strength of a chlorinated polyolefin compound, and a method of preparing a polyolefin using the same: wherein all the variables are described herein.

Abstract: The present invention relates to a polyethylene copolymer which has excellent processability and long-term durability, and thus is useful for hollow molding of a pipe or the like.

Abstract: A tuning method for a clutch temperature estimation model may include, generating n tuning genes, calculating a tuning value corresponding to a tuning variable by using information of each of the n tuning genes, calculating a temperature estimation accuracy by applying the calculated tuning value to the clutch temperature estimation model, extracting n tuning genes of highest calculated accuracies, and regenerating m tuning genes through recombination of the extracted n tuning genes.

Abstract: Provided is a foldable box having a left part and a right part, the left and right parts which include a pair of left auxiliary plates and a pair of right auxiliary plates, respectively, and most of which is made of a hard material, and therefore, it is possible to protect an item stored therein from an external impact and easily fold or unfold the foldable box, thereby maximizing convenience of storage and use.

Abstract: The present invention relates to a composition for treating or sensitizing interferon beta resistant cancer disease comprising cFLIP siRNA, and, more specifically, to a pharmaceutical composition for treating interferon beta resistant cancer disease, comprising, as an active ingredient: (a) an siRNA complementarily binding to mRNA of a cFLIP gene; and (b) a human interferon beta variant which comprises glycine-asparagine-isoleucine-treonine-valine sequence (GNITV) at C-terminus in a human natural interferon beta amino acid sequence shown in SEQ ID NO: 1, or has replaced the 27th arginine amino acid with threonine or serine, and to a composition for sensitizing interferon beta resistant cancer cells comprising cFLIP siRNA as an active ingredient.

Abstract: Provided is a foldable box having a left part and a right part, the left and right parts which include a pair of left auxiliary plates and a pair of right auxiliary plates, respectively, and most of which is made of a hard material, and therefore, it is possible to protect an item stored therein from an external impact and easily fold or unfold the foldable box, thereby maximizing convenience of storage and use.

Abstract: Disclosed is a four-wheeled folding handcart, including: a main body; and a loading plate provided with at least one loading plate wheel unit at a lower portion thereof, connected to the main body via a hinge unit such that the loading plate is folded by the hinge unit while being rotated toward the main body, and loading an article thereon. The loading plate wheel unit is connected to a wheel rod rotated by the rotation of the hinge unit in a direction perpendicular to a rotational direction of the hinge unit. The loading plate wheel unit is configured such that, when the loading plate is rotated and folded, the loading plate wheel unit is rotated and folded as the wheel rod rotates, and when the loading plate is rotated and unfolded, the loading plate wheel unit is rotated and unfolded as the wheel rod rotates reversely.

Abstract: Provided is a foldable box having a left part and a right part, the left and right parts which include a pair of left auxiliary plates and a pair of right auxiliary plates, respectively, and most of which is made of a hard material, and therefore, it is possible to protect an item stored therein from an external impact and easily fold or unfold the foldable box, thereby maximizing convenience of storage and use.