Abstract: The present disclosure relates to a system for measuring changes in the vital signs of poultry and a method for predicting whether poultry is infected with pathogens using the same. The present disclosure can be helpfully used to determine an overall health condition including the outbreak of various poultry diseases by measuring quantitative changes in vital signs of poultry in real time. In particular, the present disclosure provides reliable real-time information about changes in vital signs through comparison of body temperature and noise measurement values of poultry for each time period reflecting circadian changes of the poultry, rather than simple comparison of the body temperature and noise measurement values with simple reference values, and thus can be used for early diagnosis of highly infectious pathogens such as avian influenza virus and early isolation of confirmed cases, and ultimately for effective prevention of the spread of diseases.