Patents by Inventor Kyu-Kye Hwang

Kyu-Kye Hwang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210340503
    Abstract: The present invention includes methods and compositions for the production of high titer recombinant Adeno-Associated Virus (rAAV) in a variety of mammalian cells. The disclosed rAAV are useful in gene therapy applications. Disclosed methods based on co-infection of cells with two or more replication-defective recombinant herpes virus (rHSV) vectors are suitable for high-titer, large-scale production of infectious rAAV.
    Type: Application
    Filed: March 15, 2021
    Publication date: November 4, 2021
    Inventors: Kyu-Kye Hwang, David R. Knop, James Conway, Barry J. Byrne
  • Publication number: 20190017033
    Abstract: The present invention includes methods and compositions for the production of high titer recombinant Adeno-Associated Virus (rAAV) in a variety of mammalian cells. The disclosed rAAV are useful in gene therapy applications. Disclosed methods based on co-infection of cells with two or more replication-defective recombinant herpes virus (rHSV) vectors are suitable for high-titer, large-scale production of infectious rAAV.
    Type: Application
    Filed: April 10, 2018
    Publication date: January 17, 2019
    Inventors: Kyu-Kye Hwang, David R. Knop, James Conway, Barry J. Byrne
  • Publication number: 20170362577
    Abstract: The present invention includes methods and compositions for the production of high titer recombinant Adeno-Associated Virus (rAAV) in a variety of mammalian cells. The disclosed rAAV are useful in gene therapy applications. Disclosed methods based on co-infection of cells with two or more replication-defective recombinant herpes virus (rHSV) vectors are suitable for high-titer, large-scale production of infectious rAAV.
    Type: Application
    Filed: February 3, 2017
    Publication date: December 21, 2017
    Inventors: Kyu-Kye Hwang, David Knop, James Conway, Barry J. Byrne
  • Publication number: 20160024480
    Abstract: The present invention includes methods and compositions for the production of high titer recombinant Adeno-Associated Virus (rAAV) in a variety of mammalian cells. The disclosed rAAV are useful in gene therapy applications. Disclosed methods based on co-infection of cells with two or more replication-defective recombinant herpes virus (rHSV) vectors are suitable for high-titer, large-scale production of infectious rAAV.
    Type: Application
    Filed: October 2, 2015
    Publication date: January 28, 2016
    Inventors: Kyu-Kye Hwang, David Knop, James Conway, Barry J. Byrne
  • Publication number: 20130171719
    Abstract: The present invention includes methods and compositions for the production of high titer recombinant Adeno-Associated Virus (rAAV) in a variety of mammalian cells. The disclosed rAAV are useful in gene therapy applications. Disclosed methods based on co-infection of cells with two or more replication-defective recombinant herpes virus (rHSV) vectors are suitable for high-titer, large-scale production of infectious rAAV.
    Type: Application
    Filed: November 20, 2012
    Publication date: July 4, 2013
    Inventors: Kyu-Kye Hwang, David Knop
  • Publication number: 20070202587
    Abstract: The present invention includes methods and compositions for the production of high titer recombinant Adeno-Associated Virus (rAAV) in a variety of mammalian cells. The disclosed rAAV are useful in gene therapy applications. Disclosed methods based on co-infection of cells with two or more replication-defective recombinant herpes virus (rHSV) vectors are suitable for high-titer, large-scale production of infectious rAAV.
    Type: Application
    Filed: August 14, 2006
    Publication date: August 30, 2007
    Inventors: Kyu-Kye Hwang, David Knop
  • Patent number: 7091029
    Abstract: The invention includes methods and compositions for the production of high titer recombinant adeno-associated virus (rAAV). The disclosed rAAV are useful in gene therapy applications. Methods are based on the use of recombinant herpes virus vectors and result in highly efficient production of rAAV.
    Type: Grant
    Filed: September 23, 2002
    Date of Patent: August 15, 2006
    Assignee: Applied Genetics Technologies Corporation
    Inventor: Kyu-Kye Hwang
  • Publication number: 20040058439
    Abstract: The invention includes methods and compositions for the production of high titer recombinant adeno-associated virus (rAAV). The disclosed rAAV are useful in gene therapy applications. Methods are based on the use of recombinant herpes virus vectors and result in highly efficient production of rAAV.
    Type: Application
    Filed: September 23, 2002
    Publication date: March 25, 2004
    Inventor: Kyu-Kye Hwang