Abstract: The present disclosure provides autotaxin (ATX) inhibitor compounds and compositions including said compounds. The present disclosure also provides methods of using said compounds and compositions for inhibiting ATX. Also provided are methods of preparing said compounds and compositions, and synthetic precursors of said compounds.

Abstract: The present disclosure relates to a novel anti-HER2 antibody or an antigen-binding fragment thereof used in the prevention or treatment of cancer, a chimeric antigen receptor including the same, and uses thereof. The antibody of the present disclosure is an antibody that specifically binds to HER2 which is highly expressed in cancer cells (particularly, breast cancer or gastric cancer cells), and binds to an epitope that is different from an epitope to which trastuzumab binds.

Abstract: A display device may include a first electrode, a second electrode, an emission layer, an intervening layer, and a first encapsulation layer. The second electrode may overlap the first electrode. The emission layer may be disposed between the first electrode and the second electrode, may overlap the first electrode, and may include a light emitting material. The intervening layer may directly contact the second electrode, may be spaced from each of the first electrode and the emission layer, and may include a fluorine compound. A first section of the first encapsulation layer may overlap the emission layer. The intervening layer may be positioned between the second electrode and a second section of the first encapsulation layer.

Abstract: A method of controlling a cooking apparatus includes a cleaning process which includes controlling a temperature in a cooking chamber such that the temperature in the cooking chamber is maintained at a preset first temperature for a preset first time, and controlling a temperature in a cooking chamber such that the temperature in the cooking chamber is maintained at a preset second temperature higher than the first temperature for a preset second time.

Abstract: The present disclosure provides a reagent composition for detecting illicit drugs, the composition comprising: a diacetylene derivative compound represented by chemical formula 1; and at least one compound selected from among gabazine (SR-95531), an amine group-linked diacetylene derivative represented by chemical formula 2-1, and a gabazine-linked diacetylene derivative represented by chemical formula 2-2.

Abstract: The present invention provides a target RNA detection method based on a dCas9/gRNA complex. A target RNA detection method according to the present invention can detect target RNA with the naked eye and without separate gene isolation and amplification steps, and, in particular, can rapidly and accurately detect target RNA through excellent target specificity and rapidity, and thus can exhibit excellent effects on the detection of various pathogens and/or viruses.

Abstract: The present invention relates to a pyrrolo-pyridine derivative compound, a method for preparing the same, and a pharmaceutical composition containing the same as an active ingredient for the prevention or treatment of protein kinase-related diseases. A compound represented by chemical formula 1, an optical isomer thereof, or a pharmaceutically acceptable salt thereof, according to the present invention, has excellent inhibitory activity against various protein kinases including DYRK1A, and therefore, the pharmaceutical composition containing the same as an active ingredient can be favorably used in the treatment or prevention of protein kinase-related diseases. Particularly, the pharmaceutical composition can be effectively used in the prevention, treatment, or alleviation of Alzheimer's disease, dementia, or Alzheimer's dementia.

Abstract: A method of controlling a cooking apparatus includes a cleaning process which includes controlling a temperature in a cooking chamber such that the temperature in the cooking chamber is maintained at a preset first temperature for a preset first time, and controlling a temperature in a cooking chamber such that the temperature in the cooking chamber is maintained at a preset second temperature higher than the first temperature for a preset second time.

Abstract: The present invention relates to a pyrrolo-pyridine derivative compound, a method for preparing the same, and a pharmaceutical composition containing the same as an active ingredient for the prevention or treatment of protein kinase-related diseases. A compound represented by chemical formula 1, an optical isomer thereof, or a pharmaceutically acceptable salt thereof, according to the present invention, has excellent inhibitory activity against various protein kinases including DYRK1A, and therefore, the pharmaceutical composition containing the same as an active ingredient can be favorably used in the treatment or prevention of protein kinase-related diseases. Particularly, the pharmaceutical composition can be effectively used in the prevention, treatment, or alleviation of Alzheimer's disease, dementia, or Alzheimer's dementia.

Abstract: A method of controlling a cooking apparatus, comprising a cleaning process comprising controlling a temperature in a cooking chamber such that the temperature in the cooking chamber is maintained at a preset first temperature for a preset first time, and controlling a temperature in a cooking chamber such that the temperature in the cooking chamber is maintained at a preset second temperature higher than the first temperature for a preset second time. A cooking apparatus comprising, a main body having a cooking chamber formed therein, a convection flow unit comprising a convection heater to heat air in the cooking chamber and a convection fan to circulate the air in the cooking chamber, and a metal foam installed at a periphery of the convection flow unit to collect and decompose cooking gas contained in the air in the cooking chamber.

Abstract: The present invention relates to a pyrrolopyridine derivative compound, a method for preparing the same, and a pharmaceutical composition containing the same as an active ingredient for the prevention or treatment of protein kinase-related diseases. A compound represented by chemical formula 1, an optical isomer thereof, or a pharmaceutically acceptable salt thereof, according to the present invention, has excellent inhibitory activity against various protein kinases including DYRK1A, and therefore, the pharmaceutical composition containing the same as an active ingredient can be favorably used in the treatment or prevention of protein kinase-related diseases. Particularly, the pharmaceutical composition can be effectively used in the prevention, treatment, or alleviation of Alzheimer's disease, dementia, or Alzheimer's dementia.

Abstract: A data processing system includes: a memory device suitable for performing an operation corresponding to a command and outputting a memory data; a data collecting device suitable for collecting big data by integrating the command and the memory data at a predetermined cycle or at every predetermined time, splitting the collected big data based on a predetermined unit, and transferring the split big data; and a data processing device suitable for storing the split big data received from the data collecting device in block-based files in a High-Availability Distributed Object-Oriented Platform (HADOOP) distributed file system (HDFS), classifying the block-based files based on a particular memory command, and processing the block-based files.

Abstract: A method of controlling a cooking apparatus, comprising a cleaning process comprising controlling a temperature in a cooking chamber such that the temperature in the cooking chamber is maintained at a preset first temperature for a preset first time, and controlling a temperature in a cooking chamber such that the temperature in the cooking chamber is maintained at a preset second temperature higher than the first temperature for a preset second time. A cooking apparatus comprising, a main body having a cooking chamber formed therein, a convection flow unit comprising a convection heater to heat air in the cooking chamber and a convection fan to circulate the air in the cooking chamber, and a metal foam installed at a periphery of the convection flow unit to collect and decompose cooking gas contained in the air in the cooking chamber.

Abstract: A cooking apparatus including a filter which may efficiently collect gas and smoke generated in a pyro-cleaning process, and a method of controlling the same. The cooking apparatus includes a main body having a cooking chamber formed therein, a vent unit configured to discharge gas in the cooking chamber to the outside of the main body, and a filter installed in at least one of the cooking chamber and the vent unit to collect gas or smoke generated in the cooking chamber. The filter includes a metal sheet.

Abstract: A data processing system includes: a memory device suitable for performing an operation corresponding to a command and outputting a memory data; a data collecting device suitable for collecting big data by integrating the command and the memory data at a predetermined cycle or at every predetermined time, splitting the collected big data based on a predetermined unit, and transferring the split big data; and a data processing device suitable for storing the split big data received from the data collecting device in block-based files in a High-Availability Distributed Object-Oriented Platform (HADOOP) distributed file system (HDFS), classifying the block-based files based on a particular memory command, and processing the block-based files.

Abstract: Methods and compositions are provided for treating an individual having cancer. Aspects of the methods include administering to the individual an inhibitor of a non-canonical Notch signaling pathway gene in an amount effective to treat the cancer. Also provided are reagents, devices and kits thereof that find use in practicing the subject methods.

Abstract: A drum washing machine and washing method are provided. The washing machine directly sprays water to laundry inside the drum through a nozzle unit. The method includes passing some water through a detergent container and directly spraying some water to the inside of a drum through a nozzle unit such that a high concentration of detergent bubbles is generated while applying a force to the laundry. The washing machine includes a cabinet, a tub inside the cabinet, a drum inside the tub, a door on the cabinet, a diaphragm, and a nozzle unit installed so interference with the door is avoided and to receive water directly from an external source to spray water inside the drum during a washing cycle and a rinsing cycle. The nozzle unit adjusts water jetting according to a displacement of an actuator installed inside the nozzle unit.

Abstract: Methods and compositions are provided for treating an individual having cancer. Aspects of the methods include administering to the individual an inhibitor of a non-canonical Notch signaling pathway gene in an amount effective to treat the cancer. Also provided are reagents, devices and kits thereof that find use in practicing the subject methods.

Abstract: A cooking apparatus including a filter which may efficiently collect gas and smoke generated in a pyro-cleaning process, and a method of controlling the same. The cooking apparatus includes a main body having a cooking chamber formed therein, a vent unit configured to discharge gas in the cooking chamber to the outside of the main body, and a filter installed in at least one of the cooking chamber and the vent unit to collect gas or smoke generated in the cooking chamber. The filter includes a metal sheet.

Abstract: A drum washing machine and washing method are provided. The washing machine directly sprays water to laundry inside the drum through a nozzle unit. The method includes passing some water through a detergent container and directly spraying some water to the inside of a drum through a nozzle unit such that a high concentration of detergent bubbles is generated while applying a force to the laundry. The washing machine includes a cabinet, a tub inside the cabinet, a drum inside the tub, a door on the cabinet, a diaphragm, and a nozzle unit installed so interference with the door is avoided and to receive water directly from an external source to spray water inside the drum during a washing cycle and a rinsing cycle. The nozzle unit adjusts water jetting according to a displacement of an actuator installed inside the nozzle unit.