Patents by Inventor Kyuichi Nemoto

Kyuichi Nemoto has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for examining chronic rejection reactions following organ transplantation and method for determining urine components
    Patent number: 6210912
    Abstract: A method for detecting the onset of chronic rejection at an early stage after organ transplantation, characterized by assaying nitrogen trioxide (NO3), matrix metalloproteinase (MMP)-2 or the precursor thereof in body fluids drawn out of body.
    Type: Grant
    Filed: February 12, 1999
    Date of Patent: April 3, 2001
    Assignee: Nippon Kayaku Kabushiki Kaisha
    Inventors: Isamu Koyama, Tadaki Yasumura, Kyuichi Nemoto, Takako Mae, Kan Saiga, Hisako Takagi, Atsuko Isoda, Toshio Tanabe
  • Novel spergualin-related compounds and compositions
    Patent number: 5061787
    Abstract: The present invention relates to novel spergualin-related compounds represented by the general formula [I]: ##STR1## wherein X is --(CH.sub.2).sub.1.about.5 or ##STR2## Y is a hydrogen atom or a residue obtained by removing a hydroxyl group from the carboxyl group of an amino acid or a peptide; m is 0, 1 or 2 and n is 1 or 2, with the proviso that Y is not a hydrogen atom when n is 2 and m is 0.This compounds are stable and exhibit a high immunosuppressive activity.
    Type: Grant
    Filed: June 8, 1989
    Date of Patent: October 29, 1991
    Assignees: Nippon Kayaku Kabushiki Kaisha, Takara Shuzo Kabushiki Kaisha
    Inventors: Tetsushi Saino, Tsugio Tomiyoshi, Kyuichi Nemoto, Yoshihisa Umeda
  • Method for relieving radiogenic or drug-induced side effects
    Patent number: 5002756
    Abstract: An agent for relieving radiogenic or drug-induced side effects, characterized by comprising a spergualin derivative of the following formula (I):NH.sub.2 --C(.dbd.NH)--NH--R.sub.1 --R.sub.2 --CONH--R.sub.3 --CONH--(CH.sub.2).sub.4 --NH--(CH.sub.2).sub.3 --NH--Xwherein R.sub.1 represents --(CH.sub.2).sub.4 --, --(CH.sub.2).sub.6 ##STR1## R.sub.2 represents --(CH.sub.2).sub.2 -- or --CH.dbd.CH--, R.sub.3 represents --(CH(OH)--CH(OMe)--, --CH.sub.2 -- or --(CH.sub.2).sub.m --CH(OH)--(CH.sub.2).sub.n -- (m represent an integer of 0,1 or 2 and n represents an integer of 1 or 2)X represents a hydrogen atom or a group formed by removing a hydroxyl group from a carboxyl group of an amino acid,or a pharmacologically acceptable salt thereof as an active ingredient.
    Type: Grant
    Filed: March 17, 1989
    Date of Patent: March 26, 1991
    Assignee: Zaidanhojin Biseibutsu Kagakukenkyukai
    Inventors: Kyuichi Nemoto, Tetsushi Saino, Tomio Takeuchi, Teruya Nakamura
  • Immunopotentiator and spergualin-related compound therefor
    Patent number: 4990536
    Abstract: The present invention provides a use for the preparation of an immunopotentiator of a spergualin-related compound represented by the following general formula [I] or a pharmacologically acceptable salt thereof: ##STR1## wherein X represents ##STR2## or --(CH.sub.2).sub.n --, Y represents a hydrogen atom or a hydroxyl or hydroxymethyl group,n is an integer of 3 or 5, andR represents --(CH.sub.2).sub.4 --R.sub.1 (wherein R.sub.1 is --NH.sub.2 or --OH), --(CH.sub.2).sub.3 --R.sub.2 (wherein R.sub.2 is --COOH or --CHO), --(CH.sub.2).sub.4 --NH--(CH.sub.2).sub.3 --OH or --(CH.sub.2).sub.4 --NH--(CH.sub.2).sub.2 --R.sub.2 (wherein R.sub.2 is as defined above).
    Type: Grant
    Filed: March 16, 1990
    Date of Patent: February 5, 1991
    Assignees: Nippon Kayaku Kabushiki Kaisha, Takara Shuzo Co., Ltd.
    Inventors: Takeji Sakasai, Tsugio Tomiyoshi, Keiko Watanabe, Kyuichi Nemoto, Tetushi Saino, Yoshihisa Umeda