Patents by Inventor Kyungae Yang

Kyungae Yang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • STEM-LOOP RECEPTOR-BASED FIELD-EFFECT TRANSISTOR SENSOR DEVICES FOR SMALL-MOLECULE TARGET DETECTION UNDER PHYSIOLOGICAL SALT CONCENTRATIONS
    Publication number: 20210223240
    Abstract: Devices for detecting at least one target molecule in a sample are provided. The devices comprise a field-effect transistor and an aptamer attached to the field-effect transistor. The aptamer comprises a capture region and a stem region, wherein the target molecule can selectively bind to the capture region of the aptamer. The stem region can change a conformation of the aptamer when the capture region binds to the target molecule. Techniques for detecting a target molecule using such devices are also provided.
    Type: Application
    Filed: February 12, 2021
    Publication date: July 22, 2021
    Applicants: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Milan STOJANOVIC, Anne Milasincic ANDREWS, Kyungae YANG, Paul S. WEISS, Nako NAKATSUKA
  • Aptamer methods and compositions
    Patent number: 11034952
    Abstract: Methods of selecting an aptamer that specifically binds to a target molecule complexed with a derivatization agent. Also disclosed are specific aptamers and methods of use thereof.
    Type: Grant
    Filed: December 17, 2018
    Date of Patent: June 15, 2021
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Milan N. Stojanovic, Tilla S. Worgall, Kyungae Yang
  • APTAMER METHODS AND COMPOSITIONS
    Publication number: 20190185845
    Abstract: Methods of selecting an aptamer that specifically binds to a target molecule complexed with a derivatization agent. Also disclosed are specific aptamers and methods of use thereof.
    Type: Application
    Filed: December 17, 2018
    Publication date: June 20, 2019
    Inventors: Milan N. Stojanovic, Tilla S. Worgall, Kyungae Yang
  • APTAMER-BASED ANALYTE ASSAYS
    Publication number: 20190136241
    Abstract: The present invention relates to aptamer-based assays to capture and/or detect analytes comprising primary and secondary aptamers, as well as compositions comprising such primary and secondary aptamers, wherein analytes comprise small molecules that offer limited mutually non-competitive epitopes to antibodies, that is, with limited ability to measure in non-competitive sandwich assays using primary and secondary antibodies or primary and secondary aptamers.
    Type: Application
    Filed: June 5, 2017
    Publication date: May 9, 2019
    Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Milan Stojanovic, Kyungae Yang, Steven Taylor, Nenad Milosavic
  • Aptamer methods and compositions
    Patent number: 10155940
    Abstract: Methods of selecting an aptamer that specifically binds to a target molecule complexed with a derivatization agent. Also disclosed are specific aptamers and methods of use thereof.
    Type: Grant
    Filed: September 15, 2015
    Date of Patent: December 18, 2018
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Milan N. Stojanovic, Tilla S. Worgall, Kyungae Yang
  • Cross-Reactive Sensor Arrays And Methods of Use
    Publication number: 20140187437
    Abstract: Disclosed herein are methods and compositions directed to the construction of aptamer-based receptors and cross-reactive sensor arrays of such receptors and the use of the same in disease detection and management.
    Type: Application
    Filed: September 27, 2013
    Publication date: July 3, 2014
    Applicant: The Trustees Of Columbia University In The City Of New York
    Inventors: Milan Stojanovic, Tilla Worgal, Kyungae Yang