Patent number: 9376429
Abstract: The present invention relates to a compound having a blocking effect against sodium ion channels, particularly Nav1.7, a preparation method thereof and the use thereof. A compound represented by formula 1 according to the invention, or a pharmaceutically acceptable salt, hydrate, solvate or isomer thereof may be effectively used for the prevention or treatment of pain, for example, acute pain, chronic pain, neuropathic pain, post-surgery pain, migraine, arthralgia, neuropathy, nerve injury, diabetic neuropathy, neuropathic disease, epilepsy, arrhythmia, myotonia, ataxia, multiple sclerosis, irritable bowel syndrome, urinary incontinence, visceral pain, depression, erythromelalgia, or paroxysmal extreme pain disorder (PEPD).
Type:
Grant
Filed:
October 15, 2013
Date of Patent:
June 28, 2016
Assignee:
Daewoong Pharmaceutical Co., Ltd.
Inventors:
Ha Young Kim, In Woo Kim, Sun Ah Jun, Yun Soo Na, Hyung Geun Lee, Min Jae Cho, Jun Hee Lee, Hyo Shin Kim, Yun Soo Yoon, Kyung Ha Chung, Ji Duck Kim
Publication number: 20150336944
Abstract: The present invention relates to a compound having a blocking effect against sodium ion channels, particularly Nav1.7, a preparation method thereof and the use thereof. A compound represented by formula 1 according to the invention, or a pharmaceutically acceptable salt, hydrate, solvate or isomer thereof may be effectively used for the prevention or treatment of pain, for example, acute pain, chronic pain, neuropathic pain, post-surgery pain, migraine, arthralgia, neuropathy, nerve injury, diabetic neuropathy, neuropathic disease, epilepsy, arrhythmia, myotonia, ataxia, multiple sclerosis, irritable bowel syndrome, urinary incontinence, visceral pain, depression, erythromelalgia, or paroxysmal extreme pain disorder (PEPD).
Type:
Application
Filed:
October 15, 2013
Publication date:
November 26, 2015
Inventors:
Ha Young Kim, In Woo Kim, Sun Ah Jun, Yun Soo Na, Hyung Geun Lee, Min Jae Cho, Jun Hee Lee, Hyo Shin Kim, Yun Soo Yoon, Kyung Ha Chung, Ji Duck Kim