Abstract: The present invention relates to a cosmetic composition for improving skin conditions that has an effect of enhancing skin defense, improving skin moisturizing, and strengthening a skin barrier, and has an antimicrobial activity. According to the present invention, production and activities of antimicrobial peptides in keratinocytes may be significantly increased, growth of Staphylococcus may be effectively inhibited, and a synergy effect may be imparted to gene expression of a skin moisturizing factor and an intercellular binding factor, such that a synergistic effect in improving skin conditions may be obtained without side effects.

Abstract: Disclosed is a nuclease-resistant RNA aptamer for inhibiting the replication of HCV replicon. This aptamer is capable of binding specifically to HCV NS5B and inhibiting the proliferation of the HCV replicon, and includes at least one sequence selected from a group consisting of SEQ ID NOS. 1 to 4, in which a fluoro group is substituted for 2?-hydroxy of both U (uracil) and C (cytosine) bases, and SEQ ID NO. 17, in which the fluoro group is substituted for the 2?-hydroxy of both the U (uracil) and the C (cytosine) bases, and which is tagged with a cholesteryl group at a 5? end and with idT at a 3? end. The RNA aptamer is useful in the diagnosis and treatment of HCV infection.

Abstract: Disclosed a nuclease-resistant RNA aptamer for inhibiting the replication of HCV replicon. This aptamer is capable of binding specifically to HCV NS5B and inhibiting the proliferation of the HCV replicon, and is composed of at least one sequence selected from a group consisting of SEQ ID NOS. 1 to 4, in which a fluoro group is substituted for 2?-hydroxy of both U (uracil) and C (cytosine) bases, and SEQ ID NO. 4, which is tagged with a cholesteryl group at a 5? end and with idT at a 3? end. The RNA aptamer is useful in the diagnosis and treatment of HCV infection.