Abstract: Conformationally constrained compounds that are novel and mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins and having bicyclic framework are disclosed, as well as their prodrugs. Such reverse-turn mimetic structures and prodrugs have utility over a wide range of fields, including use as diagnostic and therapeutic agents. The invention also relates to a use of such compounds for the preparation of a medicament for treating or preventing cancer including an acute myeloid leukemia.

Abstract: Conformationally constrained compounds that are novel and mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins and having bicyclic frame-work are disclosed, as well as their prodrugs. Such reverse-turn mimetic structures and prodrugs have utility over a wide range of fields, including use as diagnostic and therapeutic agents. The invention also relates to the use of such compounds for the preparation of a medicament for treating or preventing cancer including an acute myeloid leukemia.

Abstract: Conformationally constrained compounds that are novel and mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins and having bicyclic framework are disclosed, as well as their prodrugs. Such reverse-turn mimetic structures and pro-drugs have utility over a wide range of fields, including use as diagnostic and therapeutic agents. The invention also relates to a use of such compounds for the preparation of a medicament for treating or preventing cancer including an acute myeloid leukemia.

Abstract: Disclosed are novel reverse turn mimetics based on the framework of pyrazino-triazinone, and the use thereof in the treatment of cancers, particularly, acute myeloid leukemia. A method is also provided for manufacturing the reverse turn mimetics on a mass scale.

Abstract: Novel compounds having indazole frameworks, as well as a method for preparing the same and a pharmaceutical composition comprising the same are provided. The compounds of the present invention can inhibit protein kinase activity and thus the pharmaceutical composition of the present invention can be used to prevent or treat diseases or disorders which are related to protein kinase activity.

Abstract: Conformationally constrained compounds that are novel and mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins and having bicyclic frame-work are disclosed, as well as their prodrugs. Such reverse-turn mimetic structures and prodrugs have utility over a wide range of fields, including use as diagnostic and therapeutic agents. The invention also relates to the use of such compounds for the preparation of a medicament for treating or preventing cancer including an acute myeloid leukemia.

Abstract: A semiconductor device having a variable capacitance capacitor and a method of manufacturing the same are disclosed. An example semiconductor device includes a capacitor having a bottom electrode, a dielectric layer and an upper electrode, formed on a semiconductor substrate. The example semiconductor also includes a first insulating layer formed on the semiconductor substrate to cover the capacitor, a plurality of first contact plugs formed in a plurality of first via holes of the first insulating layer, each of which is electrically connected to either the bottom electrode or the upper electrode, a first metal wiring formed on the first insulating layer and connected to the bottom electrode through the first contact plug, a second contact plug formed on the first insulating layer and connected to the upper electrode through the first contact plug, and a second insulating layer formed on the first insulating layer to cover the first metal wiring and the second contact plug.

Abstract: Substituted phenethylamine compounds of Formula (1) that function as motilin receptor antagonists: Formula (1).

Abstract: A semiconductor device having a variable capacitance capacitor and a method of manufacturing the same are disclosed. An example semiconductor device includes a capacitor having a bottom electrode, a dielectric layer and an upper electrode, formed on a semiconductor substrate. The example semiconductor also includes a first insulating layer formed on the semiconductor substrate to cover the capacitor, a first contact plug formed in a first via hole of the first insulating layer and electrically connected to the bottom and upper electrodes, a first metal wiring formed on the first insulating layer and connected to the bottom electrode through the first contact plug, a second contact plug formed on the first insulating layer and connected to the upper electrode through the first contact plug, and a second insulating layer formed on the first insulating layer to cover the first metal wiring and the second contact plug.

Abstract: Novel amine derivatives of the following general formula (I): ##STR1## (wherein) A may denote --(CH.sub.2)--O--, --(CH.sub.2).sub.2 --O--, or --(CH.sub.2).sub.2 --NH--;B may denote --(CH.sub.2).sub.2 --;R.sub.1 may denote a hydrogen atom, a halogen atom, a nitro group, a 1-pyrrolyl group, an acetamido group, an amino group or a dimethylamino group;R.sub.2 may denote a hydrogen atom or a nitro group;R.sub.3 and R.sub.4 may denote a hydrogen atom;R.sub.8a and R.sub.8b which are the same may denote a chlorine atom or a methoxy group;R.sub.9 may denote a hydrogen atom or an amino group;R may denote a methyl group; andX may denote a methanesulfonamido group, a 1-imidazolyl group or a nitro group or a salts thereof are useful as antiarrhythmic drugs.