Abstract: The present invention relates to antibody-drug conjugates (ADCs) wherein a plurality of active agents are conjugated to an antibody through at least one branched linker. The branched linker may comprise a branching unit, and two active agents are coupled to the branching unit through a secondary linker and the branching unit is coupled to the antibody by a primary linker. The active agents may be the same or different. In certain such embodiments, two or more such branched linkers are conjugated to the antibody, e.g., 2-4 branched linkers, which may each be coupled to a different C-terminal cysteine of a heavy or light chain of the antibody. The branched linker may comprise one active agent coupled to the branching unit by a first branch and a second branch that comprises a polyethylene glycol moiety coupled to the branching unit. In certain such embodiments, two or more such branched linkers are conjugated to the antibody, e.g.

Abstract: An input sensing device includes sensor pixels initialized in response to a reset signal provided through a reset line, and output a sensing signal to a read-out line in response to a scan signal provided through a scan line. A controller generates at least one start signal and clock signals. A selector selectively provides the at least one start signal and the clock signals to first control lines or second control lines. A reset driver connected to the first control lines, and supplying reset signals to at least some of the reset lines based on the at least one start signal and the clock signals provided through the first control lines. A scan driver is connected to the second control lines, and supplies scan signals to at least some of the scan lines based on the at least one start signal and the clock signals.

Abstract: A non-aqueous electrolyte solution for a lithium secondary battery according to the present technology includes: a lithium salt; an organic solvent; and a first additive, and the first additive includes a compound represented by following Chemical formula 1: Herein, R1 is a substituted or unsubstituted unsaturated hydrocarbon group having 2 to 20 carbon atoms, and R2 is one selected from the group consisting of a substituted or unsubstituted alkyl group having 1 to 10 carbon atoms and a substituted or unsubstituted cyclic alkyl group having 3 to 8 carbon atoms.

Abstract: Disclosed is an interface system including a first neuron cluster that outputs a first neuron signal including a first neuron request and first neuron data by performing a first arithmetic operation, and a first interface circuit that stores the first neuron data and outputs a first response, in response to the first neuron request. The first neuron cluster outputs a second neuron signal including a second neuron request and second neuron data by performing a second arithmetic operation, in response to the first response. Before the first data is transmitted to a second neuron cluster different from the first neuron cluster, the first interface circuit outputs the first response in response to a fact that the first neuron data is stored.

Abstract: Disclosed are a fingerprint forgery detection device and a method of operating the same. The fingerprint forgery detection device includes a memory that stores a first feature signal including biological channel feature information of a user, a transmitter including at least one transmission electrode for transmitting a pulse signal to the user, a receiver including at least one reception electrode for receiving a biological channel response signal in response to the transmitted pulse signal, and a signal processor for processing the biological channel response signal to detect whether a fingerprint is forged, and at least one processor that controls the memory, the transmitter, and the receiver.

Abstract: Disclosed is an amplification circuit, which includes a first amplifier that receives an external signal and performs first band pass filtering on the external signal to output a first filter signal, and a second amplifier that receives the first filter signal and performs second band pass filtering on the first filter signal to output a second filter signal, and a frequency pass bandwidth of the second band pass filtering is narrower than a frequency pass bandwidth of the first band pass filtering.

Abstract: Disclosed are novel compounds of Chemical Formula 1, optical isomers of the compounds, and pharmaceutically acceptable salts of the compounds or the optical isomers. The compounds, isomers, and salts exhibit excellent activity as GLP-1 receptor agonists. In particular, they, as GLP-1 receptor agonists, exhibit excellent glucose tolerance, thus having a great potential to be used as therapeutic agents for metabolic diseases. Moreover, they exhibit excellent pharmacological safety for cardiovascular systems.

Abstract: An input sensing device includes: sensor pixels, a horizontal driver, a selection circuit, and a vertical driver. Each of the sensor pixels is connected to a plurality of driving lines and a one of a plurality of signal input lines. The horizontal driver sequentially applies a horizontal driving signal to the sensor pixels through the driving lines. The selection circuit is connected to n of the signal input lines (n is a natural number of 2 or more) and to one output line. The selection circuit sequentially outputs n sensing signals received through the n signal input lines to the one output line. The vertical driver receives the n sensing signals through the one output line. The horizontal driver applies the horizontal driving signal n times to a given one of the driving lines to correspond to the n sensing signals.

Abstract: An input sensing device includes: sensor pixels, a horizontal driver, a selection circuit, and a vertical driver. Each of the sensor pixels is connected to a plurality of driving lines and a one of a plurality of signal input lines. The horizontal driver sequentially applies a horizontal driving signal to the sensor pixels through the driving lines. The selection circuit is connected to n of the signal input lines (n is a natural number of 2 or more) and to one output line. The selection circuit sequentially outputs n sensing signals received through the n signal input lines to the one output line. The vertical driver receives the n sensing signals through the one output line. The horizontal driver applies the horizontal driving signal n times to a given one of the driving lines to correspond to the n sensing signals.

Abstract: A hybrid communication device, an operation method thereof, and a communication system including the same are provided. The hybrid communication device includes a contact unit that includes an antenna for receiving a first communication signal and an electrode for receiving a second signal, a switch controller that includes a first switch and a second switch and controls the first switch and the second switch based on a change in capacitance of the electrode, and a signal processing unit that receives at least one of the first communication signal and the second communication signal from the contact unit via the first switch and processes the received signal. The first switch is connected to the contact unit, and the signal processing unit is connected to the first switch.

Abstract: A mother substrate includes: a support substrate; a first organic layer on one surface of the support substrate; a first inorganic layer on the first organic layer and covering an edge of the first organic layer; a second organic layer on the first inorganic layer; a second inorganic layer on the second organic layer and covering an edge of the second organic layer; a plurality of display cells on the second inorganic layer; and an encapsulation cover layer on a first inorganic encapsulation area in which the first inorganic layer and the second inorganic layer are in contact with each other.

Abstract: The present invention relates to coronavirus infectious disease COVID-19 therapeutic proteins CTP alpha, CTP beta, CTP gamma, CTP delta, and uses thereof. Compared to a known peptide (P6) which mimics the binding site of a receptor binding domain (RBD) of SARS-CoV and angiotensin-converting enzyme 2 (ACE2), the therapeutic proteins CTP alpha, CTP beta, CTP gamma, and CTP delta according to the present invention comprise a novel part obtained by adding a novel sequence of amino acids, wherein the interaction of atoms constituting the amino acids has been fundamentally designed in order to strengthen the binding of SARS-CoV2 to a novel epitope of RBD.

Abstract: An information handling system display monitor transitions between flat and curved configurations by actuation of a shaped memory alloy wire within the display monitor housing. For example, a nickel titanium wire is heated by application of current across the wire to transition its crystalline form, thereby shortening the wire to adjust the configuration of a foldable display film, such as an OLED display film. Separate shaped memory alloy wires may be used to achieve foldable display film movement in each direction, or actuation of a shaped memory alloy wire in one direction may generate bias in a spring in the opposite direction that is released when a change in foldable display film configuration is desired.

Abstract: A monitor includes a metallic edge piece and a downlight module. The edge piece provides a contact surface to receive touch inputs for a touch sensor. The downlight module includes the touch sensor and a lamp. The downlight module is coupled to the edge piece to receive the touch inputs to turn on and off the lamp.

Abstract: Systems and methods are disclosed for a light cover that may include a blocking portion configured to block a light emitted from a light-emitting diode, the blocking portion having a first shape associated with a heated state in which the blocking portion extends vertically in parallel with a lower portion of an optical sheet, the first shape configured to minimize a gap between the lower portion of the optical sheet and the blocking portion; a mounting portion configured to contact a bottom portion of a cover bottom of the display, the mounting portion extending orthogonally from the blocking portion; and a plurality of mounting pegs disposed on interior portions of the mounting portion, each of the plurality of mounting pegs configured to removably couple the mounting portion of the light cover to the bottom portion of the cover bottom.

Abstract: An information handling system display monitor transitions between flat and curved configurations by actuation of a shaped memory alloy wire within the display monitor housing. For example, a nickel titanium wire is heated by application of current across the wire to transition its crystalline form, thereby shortening the wire to adjust the configuration of a foldable display film, such as an OLED display film. Separate shaped memory alloy wires may be used to achieve foldable display film movement in each direction, or actuation of a shaped memory alloy wire in one direction may generate bias in a spring in the opposite direction that is released when a change in foldable display film configuration is desired.

Abstract: Systems and methods are disclosed for a light cover that may include a blocking portion configured to block a light emitted from a light-emitting diode, the blocking portion having a first shape associated with a heated state in which the blocking portion extends vertically in parallel with a lower portion of an optical sheet, the first shape configured to minimize a gap between the lower portion of the optical sheet and the blocking portion; a mounting portion configured to contact a bottom portion of a cover bottom of the display, the mounting portion extending orthogonally from the blocking portion; and a plurality of mounting pegs disposed on interior portions of the mounting portion, each of the plurality of mounting pegs configured to removably couple the mounting portion of the light cover to the bottom portion of the cover bottom.

Abstract: A device and a method of displaying a response to an inquiry are provided. The method of displaying a response includes obtaining an inquiry indicated by a received user input, determining a response, from among a plurality of responses corresponding to the inquiry, by using context information indicating context of a user, and displaying text indicating the determined response and an image of a subject providing the response.

Abstract: A display couples a display panel over a light guide plate in a sharp edge housing by adapting the light guide plate side to have a beveled surface that fits along its perimeter into a reduced depth of the housing. The light guide plate beveled surface has angled sides relative to the light guide plate illumination side and reflective side to fit against parallel sides formed in the housing as the housing narrows towards its base where the light guide plate couples. A diffusive pattern formed in the light guide plate reflective surface that directs light towards the illumination surface extends onto the light guide plate side beveled surface.

Abstract: A display couples a display panel over a light guide plate in a sharp edge housing by adapting the light guide plate side to have a beveled surface that fits along its perimeter into a reduced depth of the housing. The light guide plate beveled surface has angled sides relative to the light guide plate illumination side and reflective side to fit against parallel sides formed in the housing as the housing narrows towards its base where the light guide plate couples. A diffusive pattern formed in the light guide plate reflective surface that directs light towards the illumination surface extends onto the light guide plate side beveled surface.