Abstract: The present invention provides novel thiazolidine-2,4-dione derivatives possessing blood sugar-lowering action and aldose reductase-inhibitory action, their salts, their preparative processes and drugs containing them, and relates to thiazolidine-2,4-dione derivatives represented by a general formula (1) ##STR1## [wherein R.sup.1 and R.sup.2 denote identically or differently hydrogen atoms or lower alkyl groups, R.sup.3 denotes a phenyl group, naphthyl group, benzoyl group or 5-membered or 6-membered heteroring and its benzene-condensed ring, which may have one or more substituents, A denotes a carbonyl group, sulfonyl group or bonding hand, and B denotes a lower alkylene, lower alkenylene or bonding hand], or their salts, or thiazolidine-2,4-dione derivatives represented by a general formula (2) ##STR2## [wherein R.sup.4 denotes a hydrogen atom or lower alkyl group, and R.sup.1 and R.sup.3 are same as above ], or their salts.

Abstract: The present invention provides novel thiazolidine-2,4-dione derivatives possessing blood sugar-lowering action and aldose reductase-inhibitory action, their salts, their preparation processes and drugs containing them, and relates to thiazolidine-2,4-dione derivatives represented by a general formula (1) ##STR1## [wherein R.sup.1 and R.sup.2 denote identically or differently hydrogen atoms, halogens, lower alkyl groups, hydroxyl groups, lower alkoxy groups, nitro groups or amino groups (said amino group may be substituted with lower alkyl group or lower alkanoyl group, R.sup.3 denotes a hydrogen atom or lower alkyl group, A denotes a lower alkylene or carbonyl group, and B and W denote differently lower alkylenes, carbonyl groups or bonding hands], or their salts.

Abstract: Urea derivatives of the following formula: ##STR1## wherein R.sub.2 indicates a piperidino or pyrrolidino group which may be substituted with a hydroxy group or a lower alkyl group having 1 to 13 carbon atoms; A indicates an ethylene group, propylene group, butylene group or butenylene group; R.sub.2 indicates a straight or branched alkyl group having 1 to 20 carbon atoms, a benzyl group, or a phenyl group which may have 1 to 3 substituents such as a lower alkyl group having 1 to 6 carbon atoms, a lower alkoxy group having 1 to 3 carbon atoms, a halogen atom, a trifluoromethyl group, an amino group, a nitro group or a methylenedioxy group; and X indicates an oxygen or sulfur atom, as well as the hydrates and pharmaceutically acceptable salts thereof are useful antiulcer agents.

Abstract: Urea derivatives of the following formula, ##STR1## wherein R.sub.1 indicates a piperidino group or pyrrolidino group which may be substituted with hydroxy group or lower alkyl group having 1 to 3 carbon atoms; A indicates an ethylene group, propylene group, butylene group or butenylene group; R.sub.2 indicates a straight or branched alkyl group having 1 to 20 carbon atoms, cycloalkyl group having 3 to 6 carbon atoms, benzyl group, or phenyl group which may have 1 to 3 substituents such as lower alkyl group having 1 to 6 carbon atoms, lower alkoxy group having 1 to 3 carbon atoms, halogen atom, trifluoromethyl group, amino group, nitro group or methylenedioxy group; X indicates an oxygen or sulfur atom, the hydrates and pharmaceutically acceptable acid addition salts thereof are useful as antiulcer agents.

Abstract: Benzimidazole derivatives of the following formula, ##STR1## wherein R.sup.1 indicates hydrogen atom, lower alkyl group having carbon atoms of 1 to 6 or dimethylaminopropyl group, R.sup.2 indicates hydrogen atom or lower alkanoyl group having carbon atoms of 1 to 3, R.sup.3 indicates hydrogen atom, lower alkyl group having carbon atoms of 1 to 3 or lower alkanoyl group having carbon atoms of 1 to 3, X indicates sulfur atom, sulfinyl group, sulfonyl group, amino group or methylene group, A indicates alkylene group having carbon atoms of 1 to 12, which alkylene group may optionally be substituted by hydroxy group or lower alkyl group having carbon atoms of 1 to 3, --(CHR')N--CR".dbd.CR"--(CHR')M--, ##STR2## (in which R' and R" are each independently hydrogen atom, lower alkyl group having carbon atoms of 1 to 3 or hydroxy group, and n and m are equal to 0, 1, 2 or 3) and Y indicates oxygen atom or sulfur atom; their acid or alkali salts and hydrate thereof are useful as antiallergic agents.

Abstract: This invention relates to novel processes for the manufacture of spiro-linked pyrrolidine-2,5-diones of formula; ##STR1## which have a potent inhibitory activity on aldose reductase and are useful for reduction and prevention of chronic diabetic complications.The invented processes are useful as improved and convenient method for a large scale manufacture.

Abstract: This invention relates to novel processes for the manufacture of spiro-linked pyrrolidine-2,5-diones of the formula; ##STR1## which have a potent inhibitory activity on aldose reductase and are useful for reduction and prevention of chronic diabetic complications.The invented processes are useful as improved and convenient method for a large scale manufacture.

Abstract: The present invention is concerned with certain novel anti-allergic agents and process for their preparation.

Abstract: This invention relates to sulfamoylbenzoic acid derivatives which possess diuretic and uricosuric activities, and which are of the formula (I) ##STR1## wherein R.sub.1 is a chlorine atom or phenoxy group, R.sub.2 is a hydrogen atom, halogen atom, lower alkyl group, lower alkoxy group or methylenedioxy group.