Patents by Inventor L. Dudley Eirich

L. Dudley Eirich has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cytochrome P450 monooxygenase and NADPH cytochrome P450 oxidoreductase genes and proteins related to the omega hydroxylase complex of Candida tropicalis and methods relating thereto
    Patent number: 6331420
    Abstract: Novel genes have been isolated which encode cytochrome P450 and NADPH reductase enzymes of the &ohgr;-hydroxylase complex of C. tropicalis 20336. Vectors including these genes, transfected host cells and transformed host cells are provided. Methods of producing of cytochrome P450 and NADPH reductase enzymes are also provided which involve transforming a host cell with a gene encoding these enzymes and culturing the cells. Methods of increasing the production of a dicarboxylic acid and methods of increasing production of the aforementioned enzymes are also provided which involve increasing in the host cell the number of genes encoding these enzymes. A method for discriminating members of a gene family by quantifying the expression of genes is also provided.
    Type: Grant
    Filed: April 30, 1999
    Date of Patent: December 18, 2001
    Inventors: C. Ron Wilson, David L. Craft, L. Dudley Eirich, Mark Eshoo, Krishna M. Madduri, Cathy A. Cornett, Alfred A. Brenner, Maria Tang, John C. Loper, Martin Gleeson
  • Method for increasing the omega-hydroxylase activity in candida tropicals
    Patent number: 5648247
    Abstract: The omega-hydroxylase activity in the yeast Candida tropicalis is increased by amplification of the P450ALK and P450RED genes. The specific productivity (grams of dicarboxylic acid/liter/hr) of substantially pure alpha, omega-dicarboxylic acids is increased by culturing C. tropicalis strains having amplified P450ALK and P450RED genes.
    Type: Grant
    Filed: April 19, 1995
    Date of Patent: July 15, 1997
    Assignee: Henkel Corporation
    Inventors: Stephen Picataggio, Tracy Rohrer, L. Dudley Eirich
  • Method for increasing the omega-hydroxylase activity in Candida tropicalis
    Patent number: 5620878
    Abstract: The omega-hydroxylase activity in the yeast Candida tropicalis is increased by amplification of the P450ALK and P450RED genes. The specific productivity (grams of dicarboxylic acid/liter/hr) of substantially pure alpha, omega-dicarboxylic acids is increased by culturing C. tropicalis strains having amplified P450ALK and P450RED genes.
    Type: Grant
    Filed: March 17, 1995
    Date of Patent: April 15, 1997
    Assignee: Henkel Corporation
    Inventors: Stephen Picataggio, Tracy Rohrer, L. Dudley Eirich
  • Site-specific modification of the candida tropicals genome
    Patent number: 5254466
    Abstract: The POX genes of C. tropicalis are disrupted resulting in the complete blockage of the beta-oxidation pathway in the strain. Fermentation of C. tropicalis cells having disrupted genes on alkane, fatty acid and fatty acid ester substrates produces substantially pure dicarboxylic acids in substantially quantitative yield.
    Type: Grant
    Filed: November 6, 1989
    Date of Patent: October 19, 1993
    Assignee: Henkel Research Corporation
    Inventors: Stephen Picataggio, Kristine Deanda, L. Dudley Eirich