Patents by Inventor L. Henry Edmunds, Jr.

L. Henry Edmunds, Jr. has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of inhibiting blood coagulation in extracorporeal circulation by inhibiting human tissue factor
    Patent number: 5437864
    Abstract: This invention provides a method of inhibiting coagulation in extracorporeal circulation in a subject, comprising administration of a therapeutically effective amount of a monoclonal antibody which inhibits the ability of tissue factor to bind to factor VII/VIIa. The method prevents complex formation between tissue factor and factor VII/VIIa and thus inhibits coagulation of blood in extracorporeal procedures such as cardiopulmonary bypass and other shunt procedures. Anti-tissue factor monoclonal antibodies produced by hybridoma cell lines TFS-5G9 or TF9-6B4 may be used in the claimed methods.
    Type: Grant
    Filed: November 16, 1992
    Date of Patent: August 1, 1995
    Assignees: The Scripps Research Institute, Trustees of the University of Pennsylvania, Temple University - Of the Commonwealth Systems of Higher Education
    Inventors: Thomas S. Edgington, Robert W. Colman, Janos Kappelmayer, L. Henry Edmunds, Jr., Alvise Bernabei