Patents by Inventor L. Jackson Roberts

L. Jackson Roberts has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Use of scavengers of reactive gamma-ketoaldehydes to extend cell lifespan and healthspan
    Patent number: 11633370
    Abstract: Methods and compounds for use in promoting survival of at least one eukaryotic cell, wherein the compounds are effective as gamma-ketoaldehyde scavengers.
    Type: Grant
    Filed: July 6, 2017
    Date of Patent: April 25, 2023
    Assignee: Vanderbilt University
    Inventors: L. Jackson Roberts, II, Thuy T. Nguyen
  • Methods for treating atherosclerosis with gamma-ketoaldehyde scavengers
    Patent number: 11389414
    Abstract: A method of treating atherosclerosis, comprising administering to a patient in need there of an effective gamma-ketoaldehyde scavenging amount of a gamma-ketoaldehyde scavenging compound.
    Type: Grant
    Filed: April 27, 2018
    Date of Patent: July 19, 2022
    Assignee: Vanderbilt University
    Inventors: Macrae F. Linton, John A. Oates, Sean S. Davies, L. Jackson Roberts, II, Venkataraman Amarnath, Patricia G. Yancey, Huan Tao
  • METHODS FOR TREATING INFLAMMATION AND HYPERTENSION WITH GAMMA-KETOALDEHYDE SKAVENGERS
    Publication number: 20210261508
    Abstract: A method of treating at least one of inflammation, psoriasis, and/or hypertension comprising administering to a patient in need there of an effective gamma-ketoaldehyde scavenging amount of a gamma-ketoaldehyde scavenging compound.
    Type: Application
    Filed: April 13, 2021
    Publication date: August 26, 2021
    Inventors: L. Jackson Roberts, II, Venkataraman Amarnath, David G. Harrison, Annet Kirabo
  • Methods for treating inflammation and hypertension with ?-ketoaldehyde skavengers
    Patent number: 10975033
    Abstract: A method of treating at least one of inflammation, psoriasis, and/or hypertension comprising administering to a patient in need there of an effective gamma-ketoaldehyde scavenging amount of a gamma-ketoaldehyde scavenging compound.
    Type: Grant
    Filed: July 12, 2012
    Date of Patent: April 13, 2021
    Assignee: Vanderbilt University
    Inventors: L. Jackson Roberts, II, Venkataraman Amarnath, David G. Harrison, Annet Kirabo
  • Inhibitors of hemeprotein-catalyzed lipid peroxidation
    Patent number: 10675285
    Abstract: Methods and compounds for the treatment or prevention of oxidative damage in a mammalian subject. The treatment and/or prevention may be on inhibiting heme-induced lipid peroxidation. Also discloses are methods and compounds for treating or preventing isoprostane-mediated tissue damage.
    Type: Grant
    Filed: September 15, 2015
    Date of Patent: June 9, 2020
    Assignee: Vanderbilt University
    Inventors: John A. Oates, L. Jackson Roberts, Ned A. Porter, Olivier Boutaud
  • METHODS FOR TREATING ATHEROSCLEROSIS WITH GAMMA-KETOALDEHYDE SCAVENGERS
    Publication number: 20200138747
    Abstract: A method of treating atherosclerosis, comprising administering to a patient in need there of an effective gamma-ketoaldehyde scavenging amount of a gamma-ketoaldehyde scavenging compound.
    Type: Application
    Filed: April 27, 2018
    Publication date: May 7, 2020
    Inventors: MacRae F. Linton, John A. Oates, Sean S. Davies, L. Jackson Roberts, II, Venkataraman Amarnath, Patricia G. Yancey, Huan Tao
  • USE OF 2-HYDROXYBENZYLAMINE IN THE TREATMENT AND PREVENTION OF PULMONARY HYPERTENSION
    Publication number: 20190314302
    Abstract: Compounds for use in methods of treating, preventing, or ameliorating pulmonary hypertension; reducing glutamine metabolism in a patient in need thereof, and/or increasing SIRT3 activity in a patient in need thereof.
    Type: Application
    Filed: November 15, 2017
    Publication date: October 17, 2019
    Inventors: Joshua P. Fessel, L. Jackson Roberts, II, James West
  • Prevention And Treatment Of Atrial Fibrillation/Flutter With Gamma-Ketoaldehyde Scavengers
    Publication number: 20190247375
    Abstract: Methods and compositions for use in treating atrial fibrillation in a subject. The compounds of the present invention are gamma-ketoaldehyde scavengers.
    Type: Application
    Filed: July 7, 2017
    Publication date: August 15, 2019
    Inventors: Katherine T. MURRAY, L. Jackson ROBERTS, II, Venkataraman AMARNATH
  • Use of Scavengers of Reactive Gamma-Ketoaldehydes to Extend Cell Lifespan and Healthspan
    Publication number: 20190240170
    Abstract: Methods and compounds for use in promoting survival of at least one eukaryotic cell, wherein the compounds are effective as gamma-ketoaldehyde scavengers.
    Type: Application
    Filed: July 6, 2017
    Publication date: August 8, 2019
    Inventors: L. Jackson Roberts, II, Thuy T. Nguyen
  • Inhibitors of hemeprotein-catalyzed lipid peroxidation
    Patent number: 9545385
    Abstract: Compounds, compositions and methods related to the prevention or treatment of isoprostane-mediated tissue damage in a mammalian subject in need thereof.
    Type: Grant
    Filed: February 5, 2014
    Date of Patent: January 17, 2017
    Assignee: Vanderbilt University
    Inventors: John A. Oates, L. Jackson Roberts, Ned A. Porter, Olivier Boutaud
  • Inhibitors of Hemeprotein-Catalyzed Lipid Peroxidation
    Publication number: 20160067256
    Abstract: Methods and compounds for the treatment or prevention of oxidative damage in a mammalian subject. The treatment and/or prevention may be on inhibiting heme-induced lipid peroxidation. Also discloses are methods and compounds for treating or preventing isoprostane-mediated tissue damage.
    Type: Application
    Filed: September 15, 2015
    Publication date: March 10, 2016
    Inventors: John A. Oates, L. Jackson Roberts, Ned A. Porter, Olivier Boutaud
  • INHIBITORS OF HEMEPROTEIN-CATALYZED LIPID PEROXIDATION
    Publication number: 20150368241
    Abstract: Compounds, compositions and methods related to the prevention or treatment of isoprostane-mediated tissue damage in a mammalian subject in need thereof.
    Type: Application
    Filed: February 5, 2014
    Publication date: December 24, 2015
    Inventors: John A. Oates, L. Jackson Roberts, Ned A. Porter
  • Inhibitors of hemeprotein-catalyzed lipid peroxidation
    Patent number: 9133212
    Abstract: Methods and compounds for the treatment or prevention of oxidative damage in a mammalian subject. The treatment and/or prevention may be on inhibiting heme-induced lipid peroxidation. Also discloses are methods and compounds for treating or preventing isoprostane-mediated tissue damage.
    Type: Grant
    Filed: February 5, 2013
    Date of Patent: September 15, 2015
    Assignee: Vanderbilt University
    Inventors: John A. Oates, L. Jackson Roberts, Ned A. Porter, Olivier Boutaud
  • METHODS FOR TREATING INFLAMMATION AND HYPERTENSION WITH GAMMA-KETOALDEHYDE SKAVENGERS
    Publication number: 20140256774
    Abstract: A method of treating at least one of inflammation, psoriasis, and/or hypertension comprising administering to a patient in need there of an effective gamma-ketoaldehyde scavenging amount of a gamma-ketoaldehyde scavenging compound.
    Type: Application
    Filed: July 12, 2012
    Publication date: September 11, 2014
    Applicant: VANDERBILT UNIVERSITY
    Inventors: L. Jackson Roberts, Venkataraman Amarnath, David G. Harrison
  • Isoketal scavengers and mitigation of disorders involving oxidative injury
    Patent number: 8822542
    Abstract: A method of treating and/or preventing oxidative damage, comprising administering an effective IsoK/NeuroK adduct formation suppressing amount of a phenolic amine compound and/or pyridoxamine or pyridoxamine analog, including embodiments where the phenolic compound is at least one of a pyridoxamine, salicylamine, tyrosine compound or an analog thereof.
    Type: Grant
    Filed: February 27, 2009
    Date of Patent: September 2, 2014
    Assignee: Vanderbilt University
    Inventors: L. Jackson Roberts, II, Jeffrey R. Balser, Sean S. Davies, Venkataraman Amarnath, Prakash C. Viswanathan
  • Inhibitors of hemeprotein-catalyzed lipid peroxidation
    Patent number: 8367669
    Abstract: Methods and compounds for the treatment or prevention of oxidative damage in a mammalian subject. The treatment and/or prevention may be on inhibiting heme-induced lipid peroxidation. Also discloses are methods and compounds for treating or preventing isoprostane-mediated tissue damage.
    Type: Grant
    Filed: March 26, 2008
    Date of Patent: February 5, 2013
    Assignee: Vanderbilt University
    Inventors: John A. Oates, L. Jackson Roberts, II, Ned A. Porter, Olivier Boutaud
  • ISOKETAL SCAVENGERS AND MITIGATION OF DISORDERS INVOLVING OXIDATIVE INJURY
    Publication number: 20120157501
    Abstract: A method of treating and/or preventing oxidative damage, comprising administering an effective IsoK/NeuroK adduct formation suppressing amount of a phenolic amine compound and/or pyridoxamine or pyridoxamine analog, including embodiments where the phenolic compound is at least one of a pyridoxamine, salicylamine, tyrosine compound or an analog thereof.
    Type: Application
    Filed: February 27, 2009
    Publication date: June 21, 2012
    Inventors: L. Jackson Roberts, II, Jeffrey R. Balser, Sean S. Davies, Venkataraman Amarnath, Prakash C. Viswanathan
  • Method of preventing and/or treating oxidant injury in neurodegenerative and oxidative diseases
    Patent number: 7705054
    Abstract: A method of treating and/or preventing oxidative damage, comprising administering an effective IsoK/NeuroK adduct formation suppressing amount of a phenolic amine compound and/or pyridoxamine or pyridoxamine analog, including embodiments where the phenolic compound is at least one of a pyridoxamine, salicylamine, tyrosine compound or an analog thereof.
    Type: Grant
    Filed: October 20, 2005
    Date of Patent: April 27, 2010
    Assignee: Vanderbilt University
    Inventors: L. Jackson Roberts, II, Jeffrey R. Balser, Sean S. Davies, Prakash C. Viswanathan, Venkataraman Amarnath
  • INHIBITORS OF HEMEPROTEIN-CATALYZED LIPID PEROXIDATION
    Publication number: 20080227776
    Abstract: Methods and compounds for the treatment or prevention of oxidative damage in a mammalian subject. The treatment and/or prevention may be on inhibiting heme-induced lipid peroxidation. Also discloses are methods and compounds for treating or preventing isoprostane-mediated tissue damage.
    Type: Application
    Filed: March 26, 2008
    Publication date: September 18, 2008
    Inventors: John A. Oates, L. Jackson Roberts, Ned A. Porter, Olivier Boutaud
  • Methods and compositions to assess oxidative brain injury
    Publication number: 20030211622
    Abstract: A method to assess oxidative stress in vivo includes the steps of measuring an amount of neuroprostanes in a biological sample before the ex vivo development of neuroprostanes in a sample, comparing the measured amount of neuroprostanes to a control and assessing oxidative stress in vivo based on this comparison. There is also provided a marker for oxidated stress by an increase of neuroprostanes in a biological sample compared to a control sample. A diagnostic tool for determining the presence of a neurodegenerative disease provides for determining an increased amount of neuroprostanes in a biological sample compared to that of a control sample.
    Type: Application
    Filed: March 7, 2003
    Publication date: November 13, 2003
    Inventor: L. Jackson Roberts