Patents by Inventor L. Lee Melhado

L. Lee Melhado has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Novel rhodamine derivatives as fluorogenic substrates for proteinases
    Patent number: 4640893
    Abstract: The present invention relates to a new class of novel Rhodamine derivatives. These derivatives which are bisamide substitution products are nonfluorescent. Whereas the monoamide substitution products exhibit high fluorescence. Cleavage of a single specified amide bond by bond-specific proteinases will therefore convert the nonfluorescent bisamide derivative into a highly fluorescent monoamide derivative.
    Type: Grant
    Filed: September 27, 1985
    Date of Patent: February 3, 1987
    Assignee: University of Illinois
    Inventors: Walter F. Mangel, Stephen Leytus, L. Lee Melhado
  • Rhodamine derivatives as fluorogenic substrates for proteinases
    Patent number: 4557862
    Abstract: The present invention relates to a new class of novel Rhodamine derivatives. These derivatives which are bisamide substitution products are nonfluorescent. Whereas the monoamide substitution products exhibit high fluorescence. Cleavage of a single specified amide bond by bond-specific proteinases will therefore convert the nonfluorescent bisamide derivative into a highly fluorescent monoamide derivative.
    Type: Grant
    Filed: October 28, 1983
    Date of Patent: December 10, 1985
    Assignee: University Patents, Inc.
    Inventors: Walter F. Mangel, Stephen Leytus, L. Lee Melhado