Abstract: The present disclosure encompasses methods and compositions for extended-release formulations for treating ophthalmic conditions. These formulations comprise a pharmaceutical agent, a cationic polymer, a non-ionic polymer, and a pharmaceutical carrier and are essentially preservative free. The formulations provided herein are particularly useful for sustained and controlled release of drugs and have low side effects.

Abstract: A method of treating ocular pain or discomfort, the method comprising: administering to an eye of a subject suffering from or at risk of suffering from ocular pain or discomfort, a therapeutically effective amount of chondroitin sulfate at a concentration of 0.1% to 2.5% wt/wt.

Abstract: Pharmaceutical compositions are described, the compositions comprising an immunosuppressant (such as mycophenolic acid) in combination with a very low concentration of a corticosteroid (such as betamethasone) that are capable of treating, preventing, and/or alleviating an ocular surface disease. Methods for fabricating the compositions and using them are also described.

Abstract: Chondroitin sulfate-based pharmaceutical formulations useful for the treatment of ocular pain or discomfort, such as occurring from ocular surgery, dry eye disease, ocular surgery induced dry eye disease, contact lens induced ocular surface dry eye disease, preservative induced ocular surface disease, conjunctivitis, corneal abrasion, burns, blepharitis, and stye.

Abstract: Example embodiments relate to methods and systems for playback of adaptive music corresponding to an athletic activity. A user input is received from a user selecting an existing song for audible playback to the user, the song comprising a plurality of audio layers including at least a first layer, a second layer, and a third layer. Augmented playback of the existing song to the user is initiated by audibly providing the first layer but not the second layer. Physical activity information derived from a sensor corresponding to a real-time physical activity level of a user is received. If the physical activity level of the user is above a first activity level threshold, the augmented playback of the existing song is continued by audibly providing the first layer and the second layer to the user.

Abstract: Example embodiments relate to methods and systems for playback of adaptive music corresponding to an athletic activity. A user input is received from a user selecting an existing song for audible playback to the user, the song comprising a plurality of audio layers including at least a first layer, a second layer, and a third layer. Augmented playback of the existing song to the user is initiated by audibly providing the first layer but not the second layer. Physical activity information derived from a sensor corresponding to a real-time physical activity level of a user is received. If the physical activity level of the user is above a first activity level threshold, the augmented playback of the existing song is continued by audibly providing the first layer and the second layer to the user.

Abstract: Ophthalmic compositions including an RKI, a lubricant, a deturgescent agent, a glycosaminoglycan, and water. Methods of using the ophthalmic compositions are also provided.

Abstract: Pharmaceutical kits and use of the kits in the treatment of conditions of the eye, such as dry eye disease, which includes a first composition including a corticosteroid, an immunosuppressant or both a corticosteroid and an immunosuppressant in a pharmaceutically acceptable carrier configured for administration to a subject’s eyes; a second composition including a corticosteroid in a pharmaceutically acceptable carrier configured for administration to a subject’s eyes, where the second composition has a higher concentration of corticosteroid than the first composition; and optionally a lubricating formulation that is pharmaceutical-free. Treatment of dry eye disease includes administering topically to the eyes of a subject suffering from chronic dry eye disease the first composition over a treatment period; and if the subject suffers from an episodic flare up during the treatment period, administering the second composition to substantially alleviate the flare-up.

Abstract: The present disclosure encompasses methods and compositions for extended-release formulations for treating ophthalmic conditions. These formulations comprise a pharmaceutical agent, a cationic polymer, a non-ionic polymer, and a pharmaceutical carrier and are essentially preservative free. The formulations provided herein are particularly useful for sustained and controlled release of drugs and have low side effects.

Abstract: Example embodiments relate to methods and systems for playback of adaptive music corresponding to an athletic activity. A user input is received from a user selecting an existing song for audible playback to the user, the song comprising a plurality of audio layers including at least a first layer, a second layer, and a third layer. Augmented playback of the existing song to the user is initiated by audibly providing the first layer but not the second layer. Physical activity information derived from a sensor corresponding to a real-time physical activity level of a user is received. If the physical activity level of the user is above a first activity level threshold, the augmented playback of the existing song is continued by audibly providing the first layer and the second layer to the user.

Abstract: Pharmaceutical compositions and methods for treating ocular disorders in a subject, which include betamethasone or a pharmaceutically acceptable salt thereof at a concentration of 0.01% w/w to 0.08% w/w, mycophenolic acid or a pharmaceutically acceptable salt thereof at a concentration of 0.05% w/w to 0.30% w/w, or both betamethasone and mycophenolic acid or their salts.

Abstract: Example embodiments relate to methods and systems for playback of adaptive music corresponding to an athletic activity. A user input is received from a user selecting an existing song for audible playback to the user, the song comprising a plurality of audio layers including at least a first layer, a second layer, and a third layer. Augmented playback of the existing song to the user is initiated by audibly providing the first layer but not the second layer. Physical activity information derived from a sensor corresponding to a real-time physical activity level of a user is received. If the physical activity level of the user is above a first activity level threshold, the augmented playback of the existing song is continued by audibly providing the first layer and the second layer to the user.

Abstract: Pharmaceutical compositions are described, the compositions comprising an immunosuppressant (such as mycophenolic acid) in combination with a very low concentration of a corticosteroid (such as betamethasone) that are capable of treating, preventing, and/or alleviating an ocular surface disease. Methods for fabricating the compositions and using them are also described.

Abstract: A method for delivering fluids, drugs, or medications to a patient's eye, and a system or apparatus for implementing the method, is disclosed. The system and method comprises the use of a corneal sponge to be deposited onto the cornea of the patient's eye while the patient's eyelids are maintained in open positions, and a scleral contact lens is disposed onto the sponge. The scleral lens has an irrigation fluid supply tube fluidically connected thereto for supplying a fluid, drug, or medication to the sponge which is saturated with the fluid, drug, or medication. Once the sponge and lens are inserted onto the corneal region of the eye, the patient's eyelids are closed thereby trapping and maintaining the sponge and lens upon the corneal region of the eye so as to permit the fluid, drug, or medication to be continuously supplied and applied to the corneal region of the eye.

Abstract: A therapeutic lens for the treatment of an epithelial defect comprises a layer of therapeutic material disposed over the stroma and/or Bowman's membrane to inhibit water flow from the tear liquid to the stroma and/or Bowman's membrane, such that corneal deturgescence can be restored to decrease corneal swelling and light scattering. The layer may cover and protect nerve fibers to decrease pain. The layer may comprise an index of refraction to inhibit light scatter from an anterior surface of the stroma and/or Bowman's membrane. The lens may comprise a curved anterior surface that provides functional vision for the patient when the epithelium regenerates. The layer of therapeutic material can be positioned on the eye in many ways, for example with a spray that is cured to adhere the layer to the exposed surface of the stroma and/or Bowman's membrane.

Abstract: Example embodiments relate to methods and systems for playback of adaptive music corresponding to an athletic activity. A user input is received from a user selecting an existing song for audible playback to the user, the song comprising a plurality of audio layers including at least a first layer, a second layer, and a third layer. Augmented playback of the existing song to the user is initiated by audibly providing the first layer but not the second layer. Physical activity information derived from a sensor corresponding to a real-time physical activity level of a user is received. If the physical activity level of the user is above a first activity level threshold, the augmented playback of the existing song is continued by audibly providing the first layer and the second layer to the user.

Abstract: Example embodiments relate to methods and systems for playback of adaptive music corresponding to an athletic activity. A user input is received from a user selecting an existing song for audible playback to the user, the song comprising a plurality of audio layers including at least a first layer, a second layer, and a third layer. Augmented playback of the existing song to the user is initiated by audibly providing the first layer but not the second layer. Physical activity information derived from a sensor corresponding to a real-time physical activity level of a user is received. If the physical activity level of the user is above a first activity level threshold, the augmented playback of the existing song is continued by audibly providing the first layer and the second layer to the user.

Abstract: Example embodiments relate to systems, methods, apparatuses, and computer readable media relating to a user interface, that may for example, initiate transmission of a stream of audio data comprising a plurality of audio tracks from a music streaming service, and receive athletic activity data relating to a performance of an athletic activity by a user during an activity time period that includes a plurality of time intervals. For each of the plurality of time intervals, an athletic activity level is determined from the athletic activity data, a target audio track intensity corresponding to the athletic activity level is determined, and a playback of a streamed audio track corresponding to the target audio track intensity is initiated.

Abstract: A method for delivering fluids, drugs, or medications to a patient's eye, and a system or apparatus for implementing the method, is disclosed. The system and method comprises the use of a corneal sponge to be deposited onto the cornea of the patient's eye while the patient's eyelids are maintained in open positions, and a scleral contact lens is disposed onto the sponge. The scleral lens has an irrigation fluid supply tube fluidically connected thereto for supplying a fluid, drug, or medication to the sponge which is saturated with the fluid, drug, or medication. Once the sponge and lens are inserted onto the corneal region of the eye, the patient's eyelids are closed thereby trapping and maintaining the sponge and lens upon the corneal region of the eye so as to permit the fluid, drug, or medication to be continuously supplied and applied to the corneal region of the eye.

Abstract: The present invention relates generally to a medicinal solution, and more particularly to a medicinal solution which is to be continuously or pulse-delivered for the purpose of treating various ocular diseases, conditions, or maladies, such as keratoconus, infectious keratitis, severe inflammatory conditions, and ocular surface neoplasia. In particular, the medicinal solution comprises the combination of a medication for treating one of the aforenoted or similar diseases, conditions, or maladies, and an anesthetic for rendering the patient comfortable during the treatment procedure.