Abstract: A polyacrylamide-based copolymer reduces or prevents aggregation of biologic molecules including proteins, peptides, and nucleic acids, and lipid-based vehicles such as liposomes, lipid nanoparticles, polymerosomes, and micelles, in aqueous formulations at hydrophobic interfaces, thereby increasing the thermal stability of the molecules in the formulation. Methods and compositions comprising the copolymer and a protein or the copolymer and insulin can be used for treating conditions including diabetes.

Abstract: An annular seal for installation in an annular groove defined at an interface between first and second wellhead component is disclosed. The seal has an annular body with first and second legs that define an annular channel at the inside diameter face of the annular body. The annular channel is configured to define a pressure cavity within the annular groove between the first and second wellhead component. The outside diameter face of the annular body has a tapered profile in cross-section, and the first and second legs have enlarged ends configured for engaging the inside diameter wall of the annular groove.

Abstract: A polyacrylamide-based copolymer reduces or prevents aggregation of biologic molecules including proteins, peptides, and nucleic acids, and lipid-based vehicles such as liposomes, lipid nanoparticles, polymerosomes, and micelles, in aqueous formulations at hydrophobic interfaces, thereby increasing the thermal stability of the molecules in the formulation. Methods and compositions comprising the copolymer and a protein or the copolymer and insulin can be used for treating conditions including diabetes.

Abstract: Polyacrylamide-based copolymers act as stabilizing excipients in formulations of antibody biopharmaceutical agents without interacting directly with the antibody or altering its pharmacokinetic properties. The polyacrylamide-based copolymers confer a substantial stability benefit to high concentration compositions of a variety of antibodies by precluding adsorption of the antibody to the interfaces of the composition, preventing undesirable aggregation events and maintaining the binding activity of the antibody. Such antibody compositions are useful in methods of administering the composition to a subject.

Abstract: Polyacrylamide-based copolymers act as stabilizing excipients in formulations of antibody biopharmaceutical agents without interacting directly with the antibody or altering its pharmacokinetic properties. The polyacrylamide-based copolymers confer a substantial stability benefit to high concentration compositions of a variety of antibodies by precluding adsorption of the antibody to the interfaces of the composition, preventing undesirable aggregation events and maintaining the binding activity of the antibody. Such antibody compositions are useful in methods of administering the composition to a subject.

Abstract: A polyacrylamide-based copolymer reduces or prevents aggregation of biologic molecules including proteins, peptides, and nucleic acids, and lipid-based vehicles such as liposomes, lipid nanoparticles, polymerosomes, and micelles, in aqueous formulations at hydrophobic interfaces, thereby increasing the thermal stability of the molecules in the formulation. Methods and compositions comprising the copolymer and a protein or the copolymer and insulin can be used for treating conditions including diabetes.

Abstract: Polyacrylamide-based copolymers act as stabilizing excipients in formulations of antibody biopharmaceutical agents without interacting directly with the antibody or altering its pharmacokinetic properties. The polyacrylamide-based copolymers confer a substantial stability benefit to high concentration compositions of a variety of antibodies by precluding adsorption of the antibody to the interfaces of the composition, preventing undesirable aggregation events and maintaining the binding activity of the antibody. Such antibody compositions are useful in methods of administering the composition to a subject.

Abstract: A highly elastic annular seal assembly includes a metal stabilator having inner and outer spaced-apart and projecting annular plates coupled to a common base and forming a U-shaped geometry, and a metal seal ring having inner and outer spaced-apart and projecting annular plates coupled to a common base and having a U-shaped geometry with a central groove. The stabilator plates are configured to be disposed within the central groove between the seal ring plates, and the stabilator plates being configured to gradually urge the seal ring plates outward as the seal ring and stabilator are brought together until a portion of the first seal ring plate contacts and forms a seal against a mating body disposed within the first seal ring plate.

Abstract: A polyacrylamide-based copolymer reduces or prevents aggregation of biologic molecules including proteins, peptides, and nucleic acids, and lipid-based vehicles such as liposomes, lipid nanoparticles, polymerosomes, and micelles, in aqueous formulations at hydrophobic interfaces, thereby increasing the thermal stability of the molecules in the formulation. Methods and compositions comprising the copolymer and a protein or the copolymer and insulin can be used for treating conditions including diabetes.

Abstract: A polyacrylamide-based copolymer reduces or prevents aggregation of biologic molecules including proteins, peptides, and nucleic acids, and lipid-based vehicles such as liposomes, lipid nanoparticles, polymerosomes, and micelles, in aqueous formulations at hydrophobic interfaces, thereby increasing the thermal stability of the molecules in the formulation. Methods and compositions comprising the copolymer and a protein or the copolymer and insulin can be used for treating conditions including diabetes.

Abstract: Polyacrylamide-based copolymers act as stabilizing excipients in formulations of antibody biopharmaceutical agents without interacting directly with the antibody or altering its pharmacokinetic properties. The polyacrylamide-based copolymers confer a substantial stability benefit to high concentration compositions of a variety of antibodies by precluding adsorption of the antibody to the interfaces of the composition, preventing undesirable aggregation events and maintaining the binding activity of the antibody. Such antibody compositions are useful in methods of administering the composition to a subject.

Abstract: A polyacrylamide-based copolymer reduces or prevents aggregation of biologic molecules including proteins, peptides, and nucleic acids, and lipid-based vehicles such as liposomes, lipid nanoparticles, polymerosomes, and micelles, in aqueous formulations at hydrophobic interfaces, thereby increasing the thermal stability of the molecules in the formulation. Methods and compositions comprising the copolymer and a protein or the copolymer and insulin can be used for treating conditions including diabetes.

Abstract: A pressure-energized bidirectional seal having a main body having a first end and a second end and a pair of legs extending from the second end of the main body, the pair of legs having an inner surface and an outer surface, the inner surface forming a hollow interior opening in a first direction. The bidirectional seal includes at least one rib extending from the outer surfaces and configured to sealingly engage a mating surface of a mating body the at least one rib forming a sealing zone opening in a second direction opposite of the first direction.

Abstract: A polyacrylamide-based copolymer reduces or prevents aggregation of biologic molecules including proteins, peptides, and nucleic acids, and lipid-based vehicles such as liposomes, lipid nanoparticles, polymerosomes, and micelles, in aqueous formulations at hydrophobic interfaces, thereby increasing the thermal stability of the molecules in the formulation. Methods and compositions comprising the copolymer and a protein or the copolymer and insulin can be used for treating conditions including diabetes.

Abstract: An annular seal for installation in an annular groove defined at an interface between first and second wellhead component is disclosed. The seal has an annular body with first and second legs that define an annular channel at the inside diameter face of the annular body. The annular channel is configured to define a pressure cavity within the annular groove between the first and second wellhead component. The outside diameter face of the annular body has a tapered profile in cross-section, and the first and second legs have enlarged ends configured for engaging the inside diameter wall of the annular groove.

Abstract: A highly elastic annular seal assembly includes a metal stabilator having inner and outer spaced-apart and projecting annular plates coupled to a common base and forming a U-shaped geometry, and a metal seal ring having inner and outer spaced-apart and projecting annular plates coupled to a common base and having a U-shaped geometry with a central groove. The stabilator plates are configured to be disposed within the central groove between the seal ring plates, and the stabilator plates being configured to gradually urge the seal ring plates outward as the seal ring and stabilator are brought together until a portion of the first seal ring plate contacts and forms a seal against a mating body disposed within the first seal ring plate.

Abstract: A system for separating support structure from a three-dimensional (3D)-printed component integrally printed with the support structure during an additive manufacturing (AM) process includes one or more transducers, indexing features configured to engage the transducer(s) and position the transducer(s) in contact with the support structure, and an electronic control unit (ECU). The ECU activates the transducer(s) which then vibrate at a predetermined resonant frequency of the support structure until the support structure fractures. A method includes engaging a transducer with an indexing feature, positioning the indexing feature with respect to the support structure such that the transducer is in contact with the support structure, and activating the transducer during a post-processing stage of the AM process, via the ECU, to cause the transducer to vibrate at the predetermined resonant frequency until the support structure fractures or breaks.

Abstract: A system for removing residual powder from a three-dimensional (3D)-printed component integrally constructed with a build plate during an additive manufacturing (AM) process includes an end-effector, an enclosure, one or more transducers, and an electronic control unit (ECU). The end-effector includes a base surrounded by a perimeter flange, and includes a through-opening that receives the build plate. A perimeter clamp attaches and seal the enclosure to a perimeter flange of the end-effector such that the enclosure, the base, and the build plate collectively form a powder containment cavity. The transducers vibrate at a predetermined frequency or range thereof. The ECU transmits a vibration control signal to the transducers during a post-processing stage of the AM process to loosen and remove the residual powder from the component and collect the loosened powder within the powder containment cavity.

Abstract: A system for removing residual powder from a three-dimensional (3D)-printed component integrally constructed with a build plate during an additive manufacturing (AM) process includes an end-effector, an enclosure, one or more transducers, and an electronic control unit (ECU). The end-effector includes a base surrounded by a perimeter flange, and includes a through-opening that receives the build plate. A perimeter clamp attaches and seal the enclosure to a perimeter flange of the end-effector such that the enclosure, the base, and the build plate collectively form a powder containment cavity. The transducers vibrate at a predetermined frequency or range thereof. The ECU transmits a vibration control signal to the transducers during a post-processing stage of the AM process to loosen and remove the residual powder from the component and collect the loosened powder within the powder containment cavity.

Abstract: A system for separating support structure from a three-dimensional (3D)-printed component integrally printed with the support structure during an additive manufacturing (AM) process includes one or more transducers, indexing features configured to engage the transducer(s) and position the transducer(s) in contact with the support structure, and an electronic control unit (ECU). The ECU activates the transducer(s) which then vibrate at a predetermined resonant frequency of the support structure until the support structure fractures. A method includes engaging a transducer with an indexing feature, positioning the indexing feature with respect to the support structure such that the transducer is in contact with the support structure, and activating the transducer during a post-processing stage of the AM process, via the ECU, to cause the transducer to vibrate at the predetermined resonant frequency until the support structure fractures or breaks.