Patents by Inventor L. Michael Glode

L. Michael Glode has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and method for inhibition of HIV production
    Patent number: 5306631
    Abstract: A method for the selective killing of HIV-infected cells, via HIV-regulated expression of a toxin gene, is provided in the present invention. Specifically, the expression of the diphtheria toxin fragment A gene is subject to tight control by cis-acting HIV regulatory sequences and trans-acting regulatory factors. Also provided is a method of protecting a host from HIV infection by the stable transformation of target cells, those cells which can be infected with HIV, with an HIV-regulated toxin gene. When such a stably transformed cell becomes infected with HIV, induction of the toxin gene prevents the replication and spread of the virus.
    Type: Grant
    Filed: April 15, 1991
    Date of Patent: April 26, 1994
    Assignee: University of Colorado Foundation, Inc.
    Inventors: Gail Harrison, Ian H. Maxwell, Francoise Maxwell, L. Michael Glode