Abstract: The present invention relates to regulatory nucleic acid sequences, in particular muscle-specific promoters, elements thereof, and other such nucleic acid sequences, that are capable of enhancing muscle-specific expression of genes. The invention also relates to expression constructs, vectors and cells comprising such muscle-specific regulatory nucleic acid sequences, and to methods of their use. The regulatory nucleic acid sequences are of particular utility for gene therapy applications, but also find utility in other areas such as bioprocessing and biotechnology.

Abstract: Aspects of the disclosure relate to compositions and methods useful for treating neurological diseases and disorders. In some embodiments, the disclosure provides a method for treating a neurological disease or disorder comprising administration of both a viral vector comprising interfering nucleic acids (e.g., artificial miRNAs) and a viral vector comprising a CYP46A1 protein. In some embodiments, the disclosure provides a method for treating Huntington's disease comprising administration of both a viral vector comprising interfering nucleic acids (e.g., artificial miRNAs) targeting the huntingtin gene (HTT) and a viral vector comprising a CYP46A1 protein. In some embodiments, the viral vector comprises a modified viral capsid, such as for preferentially targeting cells in the CNS or PNS.

Abstract: A battery charging apparatus for device charging in a vehicle includes a charging device compartment, a housing, a blower, a charger, and a duct. The charging device compartment is configured to retain at least one device. The housing includes a top member, a bottom member, and an accommodating space. The housing further includes an air-return port. The blower is in the housing and has an input port and an output port. The charger is in the housing and between the top member of the housing and the blower. The duct has an input port and an output port. The input port of the duct is coupled to the output port of the blower, and the output port of the duct is coupled to the air-return port of the housing. The duct forms a barrier between the accommodating space and the air-return port of the housing.

Abstract: The present invention relates to methods of administration of rAAV vectors in a single administration method comprising a series of sub-administrations of sub-doses of rAAV vectors. The present invention also relates to rAAV vectors comprising cardiac-specific promoters, cardiac-cell specific promoters, multi-cell cardiac specific promoters, and elements thereof. The invention also relates to rAAV vectors, pharmaceutical compositions and uses thereof in methods for treating cardiovascular disease, heart diseases and heart failure in subjects in need thereof.

Abstract: Embodiments described herein involve a novel sensor system configured to provide sensor data and respond to events from an event feed that can be facilitated by other devices and/or a social media feed. Such enmbodiments can involve a sensor system having one or more sensors, and involve systems and methods including monitoring an area with the one or more sensors to obtain first sensor data; and for processing a sensor event to provide second sensor data outside a functionality of the one or more sensors: identifying another sensor system monitoring the area having the functionality to provide the requested second sensor data, the another sensor system monitoring the area comprising one or more another sensors; transmitting instructions to the another sensor system to provide the requested second sensor data; and responding to the sensor event with the requested second sensor data received from the another sensor system.

Abstract: The technology described herein is directed to systems and methods for synthetic regulatory sequence design or production. In several aspects described herein are methods of designing and optionally synthesizing shortened or otherwise modified polynucleotide sequences from polynucleotide sequences with transcriptional regulatory functionality. In other aspects described herein are isolated nucleic acid modules and viral vectors, comprising said shortened or otherwise modified polynucleotide as designed or synthesized herein.

Abstract: A fuel testing device includes a combustion chamber having an optical access port; a visualization system that acquires images of a flame inside the combustion chamber, the images being acquired through the optical access port; and a vortex generator that perturbs a flow of a fuel inside the combustion chamber. The images are used to determine a propensity of the fuel to thermoacoustic instabilities, and the combustion chamber has a length less than 2 m.

Abstract: Controlling a level of electrosurgical energy provided to tissue based on detected arcing patterns or impedance changes. The drag force imposed on an electrode or blade of an electrosurgical instrument may be controlled by adjusting the level of electrosurgical energy based on the arcing patterns or impedance changes. The arcing patterns or impedance changes may be detected by sensing and analyzing voltage and/or current waveforms of the electrosurgical energy. The current and/or voltage waveform analysis may involve calculating impedance based on the voltage and current waveforms and calculating changes in impedance over time. The waveform analysis may involve detecting harmonic distortion using FFTs, DFTs, Goertzel filters, polyphase demodulation techniques, and/or bandpass filters. The waveform analysis may involve determining a normalized difference or the average phase difference between the voltage and current waveforms.

Abstract: A unified request queue includes multiple entries for servicing multiple types of requests. Each of the entries of the unified request queue is generally allocable to requests of any of the multiple request types. A number of entries in the unified request queue is reserved for a first request type among the multiple types of requests. The number of entries reserved for the first request type is dynamically varied based on a number of requests of the first request type rejected by the unified request queue due to allocation of entries in the unified request queue to other requests.

Abstract: A unified request queue includes multiple entries for servicing multiple types of requests. Each of the entries of the unified request queue is generally allocable to requests of any of the multiple request types. A number of entries in the unified request queue is reserved for a first request type among the multiple types of requests. The number of entries reserved for the first request type is dynamically varied based on a number of requests of the first request type rejected by the unified request queue due to allocation of entries in the unified request queue to other requests.

Abstract: An electrosurgical generator is disclosed. The generator includes an RF output stage configured to generate at least one electrosurgical waveform including a plurality of cycles; at least one sensor coupled to the RF output stage, the at least one sensor configured to measure a voltage and a current of the at least one electrosurgical waveform; and a controller coupled to the at least one sensor and the RF output stage, the controller including a proportional-integral-derivative controller having at least one of voltage limiter or a current limiter, the proportional-integral-derivative controller configured to saturate the RF output stage based on voltage-current characteristics of the RF output stage.

Abstract: The systems and methods of the present disclosure detect arcing patterns or impedance changes and adjust the level of electrosurgical energy provided to tissue based on the detected arcing patterns or impedance changes. In embodiments, the drag force imposed on the electrode or blade of an electrosurgical instrument may be controlled by adjusting the level of electrosurgical energy based on the detected arcing patterns or impedance changes. The arcing patterns or impedance changes may be detected by sensing voltage and/or current waveforms of the electrosurgical energy and analyzing the sensed voltage and/or current waveforms. The current and/or voltage waveform analysis may involve calculating impedance based on the sensed voltage and current waveforms and calculating changes in impedance over time. The waveform analysis may involve detecting harmonic distortion using FFTs, DFTs, Goertzel filters, polyphase demodulation techniques, and/or bandpass filters.

Abstract: A sanitization apparatus having ultraviolet sanitization in an enclosed container to kill bacteria and other disease carrying organisms. A horizontal or vertical sanitization unit dimensioned to fit objects of varying sizes is provided. An ultraviolet source within the sanitization unit irradiates an object with UV light which, in one embodiment generates ozone gas, thereby killing any microorganisms that might reside on the object that is being sanitized. The ultraviolet light may be installed in either the base or the cover of the sanitization unit. The base and the cover may include reflective surfaces to allow ultraviolet light to reflect and reach different angles and sides of an object that is being sanitized.

Abstract: A deicer salt having a predetermined geometric shape such as a cube, a pyramid, a parallelepiped, etc. melts ice and/or snow accumulations on surfaces. The deicer salt has a solid shaped form with a volume of about 25-225 mm3. The three dimensional deicing solid shaped form has an aspect ratio of between about 0.5 and about 1.5. The deicer salt shaped form may be produced using pre-formed molds into which a molten or concentrated deicing liquid may be poured. The deicing liquid is then hardened into the shape of the pre-formed mold resulting in solid shaped form deicer salt having a pre-determined geometric shape. Alternatively, powder or fine-particle solid form of the deicer salt may be compacted into the pre-formed molds to form the solid deicer salt shaped form. The deicer salt shaped form has a uniform shape, size and consistency.

Abstract: The invention is directed at a method and system for controlling lighting in an enclosed space. A daylight harvesting apparatus for controlling an amount of light in an associated work area comprises a sensor assembly for sensing an amount of illumination in a proximity of the apparatus; a controller for receiving a value representing the amount of illumination and for determining an lamp control signal to be provided based on the amount of illumination; and an artificial light source for providing light, corresponding to the lamp control signal, to the work area.

Abstract: A semiconductor testing system includes a compliant layer formed on a testing surface. Projections from the compliant layer form an electrical path to am electrical ground from a testing surface to a plurality of recessed ball pads disposed on a surface of a substrate. Thus, a plurality of electrical connections between a semiconductor die on the substrate and the ball pads may be tested for proper ground during a wirebonding process.