Abstract: The invention provides novel sample chambers, sample analysis units, multi-well plates, and imaging and analytical systems as well as methods for accurate, efficient and high-throughput imaging, measurement and analysis of diverse types of biological cells to obtain information such as cell count, cell size, cell concentration, cell sub-population, cell morphology, cell viability, etc.

Abstract: The present disclosure provides a device for measuring the jugular venous pressure of a patient. The device comprises a body defining a longitudinal enclosure and having a window along a length of the longitudinal enclosure to allow light to exit the longitudinal enclosure, a beam generator comprising a moveable portion mounted within the longitudinal enclosure, the beam generator configured to generate a sheet of light along a plane perpendicular to a longitudinal direction and at an adjustable position along the longitudinal direction, and direct the sheet of light out the window, an adjustment mechanism for adjusting the position of the moveable portion of the beam generator relative to the body along the longitudinal direction, and, a readout indicating the position of the sheet of light along the longitudinal direction.

Abstract: A light coupling element including a groove and a light redirecting member is described. The groove is for receiving and aligning an optical waveguide and incudes an open front end and a back end. The light redirecting member includes an input side for receiving light from an optical waveguide received and supported in the groove and a light redirecting side for changing a direction of light received from the input side. The groove may include a bottom surface extending between the front and back ends of the groove and including a raised bottom surface portion raised upwardly relative to an unraised bottom surface portion. The unraised bottom surface portion of the bottom surface may be disposed between the raised bottom surface portion of the bottom surface and the input side of the light redirecting member. Optical coupling assemblies including the light coupling element and an optical waveguide are described.

Abstract: A coupling unit includes a light coupling element comprising an attachment area for receiving and permanently attaching to a plurality of optical waveguides. One or more grooves are provided at the attachment area. Each groove is configured to receive an optical waveguide and defined by a bottom surface, a first region, a second region, and an opening. The first region is defined between the bottom surface and the second region. The first region in cross section has substantially parallel sidewalls separated by a spacing. The second region is disposed between the first region and the opening. A width of the opening is greater than the spacing.

Abstract: A heat sink retention device for retaining a heat sink, including a spring, proximate an electronic device in a circuit board. The device includes a first component configured to be attached to a circuit board, and a second component configured to be adjustably attached to the first component, and including an opening configured to retain a portion of a spring of a heat sink. When the first and second components are attached together and the first component is attached to the circuit board, the heat sink retention device is adapted to allow application of a force on the spring in order to retain the heat sink proximate an electronic device mounted on the circuit board.

Abstract: This invention relates to systems, methods, and disinfecting compositions for spraying onto surfaces to be sanitized or disinfected. Methods may include providing an aqueous hypohalite disinfecting composition, and providing a spraying system that may include a hand-held spray nozzle through which the composition is sprayed during use, and a pump and associated tubing for conveying the composition to the hand-held spray nozzle. The tubing may be specifically selected to exhibit at least a 65% recovery (no more than 35% loss) of hypohalite after 24 hours of contact between the composition and the tubing. The method may further include conveying the composition from the reservoir to the spray nozzle, and spraying the composition through the nozzle, e.g., onto the target surface. A related system may include similar components. A dilute hypohalite disinfecting composition may be provided for use with the system and/or method.

Abstract: Provided are dynamic cushioning systems (e.g., for use in insoles, orthoses, shoes, etc.), comprising: a fluid chamber (e.g., 100, 200) having at least one flexible fluid reservoir cell in each of a hindfoot and a forefoot portion, and having at least one main fluid transfer channel spanning a midfoot portion and connecting, in fluid exchange communication, the at least one hindfoot fluid reservoir cell with the at least one forefoot fluid reservoir cell to provide a reactive network of hindfoot and/or forefoot fluid reservoir cells in fluid exchange communication. The interconnected multi-reservoir networks provide optimal reactivity and dynamic positional cushioning by controlling fluid transfer rate(s) between and among the fluid reservoir cells. Also provided are methods for making the fluid chambers, along with insoles, orthoses, shoes, and other footwear, etc., comprising same.

Abstract: An optical ferrule includes at least one light affecting element configured to affect one or more characteristics of light from an optical waveguide as the light propagates in the optical ferrule, the light affecting element having an input surface. At least one receiving element receives and secures the optical waveguide to the ferrule so that an output surface of the waveguide is optically coupled to the input surface of the light affecting element. A waveguide stop limits movement of the waveguide toward the input surface of the light affecting element when the optical waveguide is installed in the receiving element. A space between the output surface of the optical waveguide and the input surface of the light affecting element is inaccessible to the optical waveguide when the optical waveguide is installed in the receiving element.

Abstract: An optical cable subassembly includes one or more optical waveguides, at least light coupling unit comprising a first attachment area permanently attached to the optical waveguides, and at least one cable retainer comprising a second attachment area permanently attached to the optical waveguides and adapted to be installed in a housing. A length of the optical waveguides between the first attachment area and the second attachment area allows a bend in the optical waveguides that provides a predetermined mating spring force at a predetermined angle of the light coupling unit when installed in the housing.

Abstract: A unitary optical ferrule is molded to include one or more elements for receiving and securing one or more optical waveguides one or more elements for affecting one or more characteristics of light from the optical waveguide while propagating the light within the ferrule. The optical ferrule also includes one or more first alignment features and one or more second alignment features that, when the ferrule is mated with a mating ferrule, each controls alignment of the ferrule with the mating ferrule along three mechanical degrees of freedom. The surface of the optical ferrule can be divided along the thickness axis into a first section and an opposing second section, wherein the first section of the surface includes the receiving and securing elements, the light affecting elements, and the first alignment features and the second section of the surface includes the second alignment features.

Abstract: A method of galvanic vestibular stimulation (GVS) may include delivering an electrical signal via transdermal electrical stimulation using a plurality of electrodes connected to a patient. The electrical signal may include an amplitude and a carrier frequency. The method may include modulating at least one of the amplitude and the carrier frequency based on a modulation waveform to modulate the electrical signal, the modulation waveform may include a modulation frequency that is less than the carrier frequency.

Abstract: The presently disclosed subject matter provides for methods and compositions for treating multiple myeloma. It relates to chimeric antigen receptors (CARs) that specifically target a G-protein coupled receptor (e.g., a G-protein coupled receptor family C group 5 member D (GPRC5D)), and immunoresponsive cells comprising such CARs. The presently disclosed CARs targeting a G-protein coupled receptor (e.g., GPRC5D) have enhanced immune-activating properties, including anti-tumor activity.

Abstract: A toilet assembly includes a flush engine having a bowl defining a sump and a trapway extending from the sump. A bowl insert is configured to be located in the bowl and a shroud is configured to be positioned over the flush engine to conceal at least a portion of the flush engine.

Abstract: The disclosure is directed to binding agents, e.g., a single chain variable fragment (scFv) that specifically binds to a flavivirus NS1 protein, as well as compositions comprising the binding agent and a method of using such compositions to induce an immune response against a flavivirus (e.g., a dengue virus). The disclosure also provides a conjugate comprising the binding agent, and a recombinant NS1 antigen.

Abstract: An assembly is provided for a turbine engine with a flowpath. This assembly includes a fuel source and an engine component. The engine component forms a peripheral boundary of the flowpath. The engine component includes a component internal passage. The engine component is configured to receive fuel from the fuel source. The engine component is configured to crack at least some of the fuel within the component internal passage thereby cooling the engine component and providing at least partially cracked fuel. The assembly is configured to direct the at least partially cracked fuel into the flowpath for combustion.

Abstract: In one example of the disclosure, a system for print fluid recirculation includes a supply manifold, a recirculation manifold, a printbar, and a recirculation pathway. The printbar includes a plurality of printheads that are in fluid communication with the supply manifold, and the recirculation manifold. The recirculation pathway is in fluid connection with the supply manifold and the recirculation manifold, and is to enable recirculation of print fluid at a controlled flow through the plurality of printheads.

Abstract: The following embodiments include magnetic based devices, systems, and techniques applicable in a bathroom setting or a kitchen setting. A magnetic cleaning system is configured to clean a surface in the bathroom setting or kitchen setting. A magnetic mounting assembly is configured to mount a magnetic accessory. A cabinet includes the magnetic mounting assembly. A shower panel may include one or more magnetic acoustic shower tiles. A levitating drain stopper system for a basin is configured to magnetic open or close an opening in the basin. A magnetic water steering device is configured to magnetically direct water in a predetermined path.

Abstract: Method starts with a processor receiving configuration settings including an identified task, a relationship data, and a criticality value. Processor initializes a communication session with an agent client device. The communication session is between a virtual caller associated with the system and the agent client device. Processor then processes an audio signal of the communication session to generate an agent utterance and generates a transcribed agent utterance based on the agent utterance using a speech-to-text processor. Processor generates a virtual caller utterance using a task-specific virtual caller neural network associated with the identified task. The virtual caller utterance can be generated based on the transcribed agent utterance. Processor then causes the virtual caller utterance to be played back in the communication session to the agent client device. Other embodiments are disclosed herein.