Abstract: A system for providing user-driven customization and enhanced personalization of interactive experiences. The system includes data storage for storing player profiles, with each including customization preferences useful in enhancing or generating one of the interactive experiences. The system includes a gameplay space adapted to provide an interactive experience, which includes one or more interactive elements. The system includes a gameplay device configured to be worn or carried by a player. A detection device detects a presence of the player in the gameplay space and obtains a unique identifier for the gameplay device. The system includes a controller retrieving a set of the customization preferences in one of the player profiles associated with the identifier.

Abstract: A climate data intercomparison and analytics service application programming interface (CDIAS-API) includes a set of basic utilities configured to map calls from client applications to single service-side methods operating on one or more disparate climate reanalysis datasets by the climate data intercomparison and analytics service, a set of extended utilities comprising scripts that call on one or more of a set of canonical operations, and one or more basic utilities, and a collections reference model configured to provide semantic alignment of variable names, method alignment of statistical operations, and output data format consistency for operations across the one or more disparate climate reanalysis datasets.

Abstract: A reanalysis ensemble service includes a plurality of conversion utilities, each conversion utility configured to convert a specific one of a plurality of disparate climate reanalysis datasets from different sources to common format files that are temporally and spatially registered, a data analytics platform for storing and operating on the different sourced common format files, a service interface for mapping service requests to analytic operations performed on the different sourced common format files by the data analytics platform, and a services library that dynamically creates data objects from one or more of the different sourced common format files in response to the analytic operations, and delivers the data objects to the service interface.

Abstract: An extended reanalysis ensemble service includes a loader services application program interface configured to receive data parameters for a set of automated multisource data provisioning operations, provide climate source data from one or more disparate climate data collections specified in the data parameters to conversion utilities for transforming the climate source data into flat, serialized block compressed sequence files, and load the sequence files to a distributed file system of the extended reanalysis ensemble service, and a reanalysis ensemble service application program interface configured to receive operational parameters for the set of automated multisource data provisioning operations, convert the operational parameters to one or more methods recognized by a service interface of the extended reanalysis ensemble service to be converted to analytical operations executed by the extended reanalysis ensemble service, and provide results of the one or more analytical operations executed by the exten

Abstract: A reanalysis ensemble service includes a plurality of conversion utilities, each conversion utility configured to convert a specific one of a plurality of disparate climate data collections from different sources to common format files that are temporally and spatially registered, where the disparate climate data collections include reanalysis data sets and forward processing data products, a data analytics platform for storing and operating on the different sourced common format files, a service interface for mapping service requests to analytic operations performed on the different sourced common format files by the data analytics platform, and a services library that dynamically creates data objects from one or more of the different sourced common format files in response to the analytic operations, and delivers the data objects to the service interface.

Abstract: Disclosed herein, are compositions and methods for the treatment of human immunodeficiency virus infection. The compositions comprise engineered transcription activator like effector nucleases (TALENs) comprising a TALE DNA binding domain flanked by two spacer sequences, and a Fokl nuclease catalytic domain. Also, described herein, are methods of using TALENs to cleave nucleic acids; and methods of administering the TALENs to subjects at risk for or having an HIV infection.

Abstract: This disclosure relates to tetrahydroisoquinolines, salts, and derivatives useful for managing mental or cognitive diseases or conditions of the brain or central nervous system. In certain embodiments, the disclosure relates to compounds and compositions having formula I: prodrugs, esters, or salts thereof, wherein the substituents are described herein.

Abstract: A system, method and computer-readable storage devices for providing an interface for an analytic service for Modern-Era Retrospective Analysis for Research and Applications (MERRA) datasets. An example system for providing the service includes a data analytics platform of an assemblage of compute and storage nodes that provide a compute-storage fabric upon which high-performance parallel operations are performed over a collection of climate data stored in a distributed file system, a sequencer that transforms the climate data, a desequencer that transforms serialized block compressed sequence files between data formats. The system includes a services library of applications that dynamically create data objects from the data as reduced final results, and a utilities library of software applications that process flat serialized block compressed sequence files. The system also includes a service interface through which a client device can access the climate data via the data analytics platform.

Abstract: This disclosure relates to tetrahydroisoquinolines, salts, and derivatives useful for managing mental or cognitive diseases or conditions of the brain or central nervous system. In certain embodiments, the disclosure relates to compounds and compositions having formula I: prodrugs, esters, or salts thereof, wherein the substituents are described herein.

Abstract: Disclosed herein, are compositions and methods for the treatment of human immunodeficiency virus infection. The compositions comprise engineered transcription activator like effector nucleases (TALENs) comprising a TALE DNA binding domain flanked by two spacer sequences, and a Fold nuclease catalytic domain. Also, described herein, are methods of using TALENs to cleave nucleic acids; and methods of administering the TALENs to subjects at risk for or having an HIV infection.

Abstract: A system, method and computer-readable storage devices for providing a climate data persistence service. A system configured to provide the service can include a climate data server that performs data and metadata storage and management functions for climate data objects, a compute-storage platform that provides the resources needed to support a climate data server, provisioning software that allows climate data server instances to be deployed as virtual climate data servers in a cloud computing environment, and a service interface, wherein persistence service capabilities are invoked by software applications running on a client device. The climate data objects can be in various formats, such as International Organization for Standards (ISO) Open Archival Information System (OAIS) Reference Model Submission Information Packages, Archive Information Packages, and Dissemination Information Packages.

Abstract: Disclosed herein are novel compositions and methods for elucidating biological activity and detection of molecular function. The methods and compositions disclosed herein can comprise the use of one or more minimotifs and a minimotif database for integrating and coordinating orthogonal knowledge derived from a variety of technological endeavors to provide systemic models representing complex biological and molecular interactions ranging from individual cells to entire organisms. The methods and compositions disclosed herein can utilize information related to biometrics including protein/protein interaction, and gene/gene interaction for evaluating cellular functions and cellular mechanisms.

Abstract: A system, method and computer-readable storage devices for providing an interface for an analytic service for Modern-Era Retrospective Analysis for Research and Applications (MERRA) datasets. An example system for providing the service includes a data analytics platform of an assemblage of compute and storage nodes that provide a compute-storage fabric upon which high-performance parallel operations are performed over a collection of climate data stored in a distributed file system, a sequencer that transforms the climate data, a desequencer that transforms serialized block compressed sequence files between data formats. The system includes a services library of applications that dynamically create data objects from the data as reduced final results, and a utilities library of software applications that process flat serialized block compressed sequence files. The system also includes a service interface through which a client device can access the climate data via the data analytics platform.

Abstract: A system, method and computer-readable storage devices for providing a climate data persistence service. A system configured to provide the service can include a climate data server that performs data and metadata storage and management functions for climate data objects, a compute-storage platform that provides the resources needed to support a climate data server, provisioning software that allows climate data server instances to be deployed as virtual climate data servers in a cloud computing environment, and a service interface, wherein persistence service capabilities are invoked by software applications running on a client device. The climate data objects can be in various formats, such as International Organization for Standards (ISO) Open Archival Information System (OAIS) Reference Model Submission Information Packages, Archive Information Packages, and Dissemination Information Packages.

Abstract: A system and method for repeatably mounting a spray device in a desired spray position. The present technique provides the spray device with an atomizing spray section and a releasable mount. The releasable mount may be mounted releasably to a mounting member, such as a positioning system. In addition, the releasable mount may be mounted releasably to the spray device, such that the releasable mount may remain attached to the mounting member in a desired spray position. Accordingly, the spray device or its substitute may be remounted to the releasable mount in the desired spray position.

Abstract: One embodiment having a flexible base with a plurality of vertical holes near its perimeter, each for housing a wind chime tube, the base further having a slit cut from one of the vertical holes into the middle of the base, allowing the base to be installed in the central portion of a wind chime, thereby effectively silencing the wind chime and protecting the tubes and nearby objects. This article works on the type of chime having multiple vertical resonant tubes that are struck by a striker connected to a sail that is urged by the wind. Other embodiments are described and shown.

Abstract: A lace tightening apparatus including a handle and a gripping platform. The gripping platform is adapted to travel up into the interior of the handle upon a compression force being applied thereto. An anvil is rigidly attached to the handle projecting downward from the underside. One or more springs are disposed within the interior, with the first end of the spring anchored to the handle within the interior and the second end connected to the gripping portion. A stylus is attached to the gripping portion having a post and an L-shaped portion including a lip. The lip is exposed outside of the anvil and projects downward away from the anvil. Therefore, when the compression force is applied to the gripping platform, the lip travels upward toward the bottom surface of the anvil such that a lace can be pinched between the lip and the bottom surface.

Abstract: A lace tightening apparatus including a handle and a gripping platform. The gripping platform is adapted to travel up into the interior of the handle upon a compression force being applied thereto. An anvil is rigidly attached to the handle projecting downward from the underside. One or more springs are disposed within the interior, with the first end of the spring anchored to the handle within the interior and the second end connected to the gripping portion. A stylus is attached to the gripping portion having a post and an L-shaped portion including a lip. The lip is exposed outside of the anvil and projects downward away from the anvil. Therefore, when the compression force is applied to the gripping platform, the lip travels upward toward the bottom surface of the anvil such that a lace can be pinched between the lip and the bottom surface.

Abstract: A pneumatically operated device. The pneumatically operated device comprises a movable member disposed within a housing. The movable member is operable to control operation of the device. Pressurized air is directed to a first side of the movable member to drive the movable member in a first direction to operate the device. The pneumatically operated device comprises a check valve disposed through an opening in the housing to enable air to vent from a second side of the movable member. The check valve may comprise a flexible cover extending over the opening and biased against the housing to form a seal.

Abstract: A pneumatic motor that includes a cylinder, a piston disposed in the cylinder, and a pneumatically-reset pilot valve. In certain embodiments, the pneumatically-reset pilot valve is configured to move to a first position in response to a change in pressure in the cylinder.