Abstract: Provided is a topical pharmaceutical gel composition of an amlodipine salt and methods for its use in the treatment of anorectal disease.

Abstract: ZnCl2 co-crystal of racemic-(±)-blarcamesine hydrochloride of formula 2a, ZnCl2 co-crystal of (S)-(?)-blarcamesine hydrochloride of formula 2b and ZnCl2 co-crystal of (R)-(+)-blarcamesine hydrochloride of formula 2c, processes for preparation thereof and pharmaceutical preparation thereof and methods of treating neurodegenerative, neurodevelopmental diseases such as Alzheimer's disease, Parkinson's disease dementia and/or Rett syndrome.

Abstract: The invention provides methods and dosing regimens for safely and effectively treating androgen-dependent prostate cancer with a gonadotrophin releasing hormone (GnRH) antagonist without causing a testosterone spike and/or other side effect of GnRH agonist therapy such as a urinary tract infection, or an arthralgia-related or cardiovascular side effect. The present disclosure also provides for methods for treating prostate cancer in a patient with a history of at least one cardiovascular event, wherein administration of degarelix to the subject decreases the likelihood of developing or experiencing an additional cardiovascular event compared to treatment with a gonadotrophin releasing hormone (GnRH) agonist.

Abstract: The invention provides methods and dosing regimens for safely and effectively treating androgen-dependent prostate cancer with a gonadotrophin releasing hormone (GnRH) antagonist without causing a testosterone spike and/or other side effect of GnRH agonist therapy such as a urinary tract infection, or an arthralgia-related or cardiovascular side effect. The present disclosure also provides for methods for treating prostate cancer in a patient with a history of at least one cardiovascular event, wherein administration of degarelix to the subject decreases the likelihood of developing or experiencing an additional cardiovascular event compared to treatment with a gonadotrophin releasing hormone (GnRH) agonist.

Abstract: The invention provides methods and dosing regimens for safely and effectively treating androgen-dependent prostate cancer with a gonadotrophin releasing hormone (GnRH) antagonist without causing a testosterone spike and/or other side effect of GnRH agonist therapy such as a urinary tract infection, or an arthralgia-related or cardiovascular side effect. The present disclosure also provides for methods for treating prostate cancer in a patient with a history of at least one cardiovascular event, wherein administration of degarelix to the subject decreases the likelihood of developing or experiencing an additional cardiovascular event compared to treatment with a gonadotrophin releasing hormone (GnRH) agonist.

Abstract: A computer-implemented method of processing a video stream comprises: feeding the at least one video stream to at least two video processing detectors, each comprising a respective deep convolutional neural network trained to detect one or more of the object or a property of the object; for each of said at least two video processing detectors, receiving a respective stream of object lightweight data records from the respective video processing detector, the stream of object lightweight data records generated based on the respective detection, and representing a property of the object; and feeding at least one stream of object lightweight data records to at least one context detector configured to perform a secondary detection based on object lightweight data of the stream of object lightweight data records, wherein the detections of the at least two video processing detectors are scheduled by a task-graph scheduler.

Abstract: The invention provides methods and dosing regimens for safely and effectively treating androgen-dependent prostate cancer with a gonadotrophin releasing hormone (GnRH) antagonist without causing a testosterone spike and/or other side effect of GnRH agonist therapy such as a urinary tract infection, or an arthralgia-related or cardiovascular side effect. The present disclosure also provides for methods for treating prostate cancer in a patient with a history of at least one cardiovascular event, wherein administration of degarelix to the subject decreases the likelihood of developing or experiencing an additional cardiovascular event compared to treatment with a gonadotrophin releasing hormone (GnRH) agonist.

Abstract: The invention provides methods and dosing regimens for safely and effectively treating androgen-dependent prostate cancer with a gonadotrophin releasing hormone (GnRH) antagonist without causing a testosterone spike and/or other side effect of GnRH agonist therapy such as a urinary tract infection, or an arthralgia-related or cardiovascular side effect. The present disclosure also provides for methods for treating prostate cancer in a patient with a history of at least one cardiovascular event, wherein administration of degarelix to the subject decreases the likelihood of developing or experiencing an additional cardiovascular event compared to treatment with a gonadotrophin releasing hormone (GnRH) agonist.

Abstract: A street lighting assembly includes an LED lighting device and a printed circuit board disposed within the LED lighting device. The printed circuit board includes an LED light module and an LED driver, the LED driver being electrically coupled to the LED light module. An optical cover is disposed over the LED light module.

Abstract: A lighting audit system includes a lighting audit docking station in communication with the smart device and a database, where the lighting audit docking station includes a targeting unit and a camera. A lighting audit method includes providing a physical parameter to a lighting audit table for a space-under-study, representing the space-under-study on a virtual map presented on a display, adding surface characteristic data for the space-under-study into the lighting audit table, measuring the physical dimensions of the space-under-study using the targeting unit, the physical dimension measurements being stored in the lighting audit table, entering into the lighting audit table parameters for a luminaire located in the space-under-study, and calculating a lighting audit for the space-under-study based on data in the lighting audit table.

Abstract: Methods and systems for controlling lighting fixtures independently with image sensors. In an embodiment, a luminaire includes a controller, an image sensor and wide-angle lens component, and a light source. The controller receives detection signal data from the image sensor and wide-angle lens component when a user is within a detection area associated with a view angle of the wide angle lens, and then determines the position of the user. The controller then controls the illuminance of the light source based on the position of the user. In particular, illuminance is increased as the user approaches a center portion of the detection area, and decreased as the user moves away from the center portion.

Abstract: A lighting audit system includes a lighting audit docking station in communication with the smart device and a database, where the lighting audit docking station includes a targeting unit and a camera. A lighting audit method includes providing a physical parameter to a lighting audit table for a space-under-study, representing the space-under-study on a virtual map presented on a display, adding surface characteristic data for the space-under-study into the lighting audit table, measuring the physical dimensions of the space-under-study using the targeting unit, the physical dimension measurements being stored in the lighting audit table, entering into the lighting audit table parameters for a luminaire located in the space-under-study, and calculating a lighting audit for the space-under-study based on data in the lighting audit table.

Abstract: Methods and systems for controlling lighting fixtures independently with image sensors. In an embodiment, a luminaire includes a controller, an image sensor and wide-angle lens component, and a light source. The controller receives detection signal data from the image sensor and wide-angle lens component when a user is within a detection area associated with a view angle of the wide angle lens, and then determines the position of the user. The controller then controls the illuminance of the light source based on the position of the user. In particular, illuminance is increased as the user approaches a center portion of the detection area, and decreased as the user moves away from the center portion.

Abstract: The invention provides methods and dosing regimens for safely and effectively treating androgen-dependent prostate cancer with a gonadotrophin releasing hormone (GnRH) antagonist without causing a testosterone spike and/or other side effect of GnRH agonist therapy such as a urinary tract infection, or an arthralgia-related or cardiovascular side effect. The present disclosure also provides for methods for treating prostate cancer in a patient with a history of at least one cardiovascular event, wherein administration of degarelix to the subject decreases the likelihood of developing or experiencing an additional cardiovascular event compared to treatment with a gonadotrophin releasing hormone (GnRH) agonist.

Abstract: The invention provides methods and dosing regimens for safely and effectively treating androgen-dependent prostate cancer with a gonadotrophin releasing hormone (GnRH) antagonist without causing a testosterone spike and/or other side effect of GnRH agonist therapy such as a urinary tract infection, or an arthralgia-related or cardiovascular side effect. The present disclosure also provides for methods for treating prostate cancer in a patient with a history of at least one cardiovascular event, wherein administration of degarelix to the subject decreases the likelihood of developing or experiencing an additional cardiovascular event compared to treatment with a gonadotrophin releasing hormone (GnRH) agonist.

Abstract: A street lighting assembly includes an LED lighting device and a printed circuit board disposed within the LED lighting device. The printed circuit board includes an LED light module and an LED driver, the LED driver being electrically coupled to the LED light module. An optical cover is disposed over the LED light module.

Abstract: A system including a luminaire lens including a surface having a coded positional data pattern, a mobile communication device including a camera and a display screen, a database having data records representing a floor plan of a building or structure, the mobile communication device in communication with the database, and a mobile communication device application, the application configured to decode the coded positional data pattern and to locate the decoded positional data on the floor plan, wherein the decoded positional data is displayed on the display screen. A method includes providing a luminaire lens having a coded positional data pattern, decoding the positional data, locating the decoded positional data on the floor plan, and displaying the decoded positional data on a display screen. A non-transitory medium having executable instructions is also described.

Abstract: A lamp having improved color quality scale is provided. The lamp has a light-transmissive envelope and a phosphor layer comprising a first phosphor and a second phosphor wherein the first phosphor has an emission band with a maximum between 590 nm and 670 nm and the second phosphor has an emission band with a maximum between 520 nm and 570 nm. The light generated by the phosphor layer, when the lamp is energized, has delta chroma values for fifteen color samples of the color quality scale within select parameters. The delta chroma values are measured in the CIE LAB color space.

Abstract: A lighting audit system includes a lighting audit docking station in communication with the smart device and a database, where the lighting audit docking station includes a targeting unit and a camera. A lighting audit method includes providing a physical parameter to a lighting audit table for a space-under-study, representing the space-under-study on a virtual map presented on a display, adding surface characteristic data for the space-under-study into the lighting audit table, measuring the physical dimensions of the space-under-study using the targeting unit, the physical dimension measurements being stored in the lighting audit table, entering into the lighting audit table parameters for a luminaire located in the space-under-study, and calculating a lighting audit for the space-under-study based on data in the lighting audit table.

Abstract: A lighting system and method for controlling illumination of the same upon detection of a user in at least one of a first detection area and a second detection area. The lighting system can include a lighting fixture having one or more lighting sources and at least two sensors associated with separate detection areas. Each sensor can send a signal to a controller associated with the lighting fixture, and the controller can be configured to vary the illumination of one or more of the lighting sources depending on the each sensor's detection area. The present subject matter facilitates energy savings since areas away from an occupied area are not illuminated. Communication between neighboring lighting fixtures is not required since each lighting fixture can detect the presence of a user in an area proximate an adjacent lighting fixture in order to trigger illumination of the lighting fixture.