Patents by Inventor Laetitia Malphettes

Laetitia Malphettes has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cell culture methods
    Patent number: 11859203
    Abstract: The present invention relates to methods for reducing the heterogeneity of a population of recombinant proteins produced in cell culture, said methods comprising growing host cells producing a recombinant protein in a cell culture medium wherein the cell culture medium comprises one or more cysteine/cystine analogs.
    Type: Grant
    Filed: November 29, 2018
    Date of Patent: January 2, 2024
    Assignee: UCB BIOPHARMA SRL
    Inventors: Valentine Chevallier, Nadine Kochanowski, Laetitia Malphettes, Vincent Adolphe Carol Cool
  • Compositions and methods for regulating cell osmolarity
    Patent number: 11279939
    Abstract: The invention provides compositions and methods for regulating intracellular osmolarity in cells, e.g., in cultured cells, including in cultured cells in bioreactors. The invention provides nucleic acids comprising at least one osmo-responsive transcriptional regulatory element (OR-TRE), and cells, vectors, products of manufacture, artificial organs or implants and the like containing an osmo-responsive transcriptional regulatory element (OR-TRE).
    Type: Grant
    Filed: September 26, 2018
    Date of Patent: March 22, 2022
    Assignee: GENENTECH, INC.
    Inventors: Laetitia Malphettes, Andrew Snowden, Inn H. Yuk
  • CELL CULTURE METHODS
    Publication number: 20200308536
    Abstract: The present invention relates to methods for reducing the heterogeneity of a population of recombinant proteins produced in cell culture, said methods comprising growing host cells producing a recombinant protein in a cell culture medium wherein the cell culture medium comprises one or more cysteine/cystine analogs.
    Type: Application
    Filed: November 29, 2018
    Publication date: October 1, 2020
    Inventors: VALENTINE CHEVALLIER, NADINE KOCHANOWSKI, LAETITIA MALPHETTES, VINCENT ADOLPHE CAROL COOL
  • CELL CULTURE METHODS
    Publication number: 20200239923
    Abstract: The present invention relates to the use of limited amounts of cysteine and tryptophan in the cell culture medium during production of recombinant proteins, and in particular antibodies. Proteins and antibodies produced under such controlled conditions exhibit reduced heterogeneity, in particular reduced charge variants heterogeneity.
    Type: Application
    Filed: May 29, 2018
    Publication date: July 30, 2020
    Inventors: BASSEM BEN YAHIA, LAETITIA MALPHETTES, NADINE KOCHANOWSKI, GILL RENNER, SANDRINE DURRAN, ANDREW JEFFREY YATES
  • COMPOSITIONS AND METHODS FOR REGULATING CELL OSMOLARITY
    Publication number: 20190127741
    Abstract: The invention provides compositions and methods for regulating intracellular osmolarity in cells, e.g., in cultured cells, including in cultured cells in bioreactors. The invention provides nucleic acids comprising at least one osmo-responsive transcriptional regulatory element (OR-TRE), and cells, vectors, products of manufacture, artificial organs or implants and the like containing an osmo-responsive transcriptional regulatory element (OR-TRE).
    Type: Application
    Filed: September 26, 2018
    Publication date: May 2, 2019
    Applicant: Genentech, Inc.
    Inventors: Laetitia MALPHETTES, Andrew Snowden, Inn H. Yuk
  • Compositions and methods for regulating cell osmolarity
    Patent number: 10100319
    Abstract: The invention provides compositions and methods for regulating intracellular osmolarity in cells, e.g., in cultured cells, including in cultured cells in bioreactors. The invention provides nucleic acids comprising at least one osmo-responsive transcriptional regulatory element (OR-TRE), and cells, vectors, products of manufacture, artificial organs or implants and the like containing an osmo-responsive transcriptional regulatory element (OR-TRE).
    Type: Grant
    Filed: November 21, 2014
    Date of Patent: October 16, 2018
    Assignee: GENENTECH, INC.
    Inventors: Laetitia Malphettes, Andrew Snowden, Inn H. Yuk
  • COMPOSITIONS AND METHODS FOR REGULATING CELL OSMOLARITY
    Publication number: 20150307888
    Abstract: The invention provides compositions and methods for regulating intracellular osmolarity in cells, e.g., in cultured cells, including in cultured cells in bioreactors. The invention provides nucleic acids comprising at least one osmo-responsive transcriptional regulatory element (OR-TRE), and cells, vectors, products of manufacture, artificial organs or implants and the like containing an osmo-responsive transcriptional regulatory element (OR-TRE).
    Type: Application
    Filed: November 21, 2014
    Publication date: October 29, 2015
    Applicant: GENENTECH, INC.
    Inventors: Laetitia MALPHETTES, Andrew SNOWDEN, Inn H. YUK
  • COMPOSITIONS AND METHODS FOR REGULATING CELL OSMOLARITY
    Publication number: 20110269233
    Abstract: The invention provides compositions and methods for regulating intracellular osmolarity in cells, e.g., in cultured cells, including in cultured cells in bioreactors. The invention provides nucleic acids comprising at least one osmo-responsive transcriptional regulatory element (OR-TRE), and cells, vectors, products of manufacture, artificial organs or implants and the like containing an osmo-responsive transcriptional regulatory element (OR-TRE).
    Type: Application
    Filed: September 15, 2009
    Publication date: November 3, 2011
    Inventors: Laetitia Malphettes, Andrew Snowden, Inn H. Yuk