Patents by Inventor Laibin Luo
Laibin Luo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240058264Abstract: Formulations and intravitreal implants containing nintedanib can be used in methods for the treatment of back-of-the-eye diseases.Type: ApplicationFiled: August 16, 2023Publication date: February 22, 2024Inventors: Paul ASHTON, Jianbing CHEN, Florian Andreas COLBATZKY, Hong GUO, Laibin LUO, Kerstin Julia SCHAEFER
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Publication number: 20220331516Abstract: An intra-orifice medicament delivery system and formation method involve a housing defining an inner chamber extending along a longitudinal axis, with the chamber wall defining one or more openings therethrough. A retention arrangement extends from the housing, and is adapted to removably retain the housing within a bodily orifice defined by an orifice wall. An osmotic delivery device is disposed within the chamber and includes an osmogen portion and medicament-including portion disposed within a semipermeable membrane. The osmogen portion expands and applies pressure to the medicament-including portion in response to absorption of a liquid from within the bodily orifice permeating through the semipermeable membrane.Type: ApplicationFiled: February 17, 2022Publication date: October 20, 2022Inventors: Susan Leers Sucheta, Nicholas Alan Wicks, Derrick Scott Sjodin, Christopher Jeremy Block, Laibin Luo
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Publication number: 20220125798Abstract: The invention describes a ready-to-use injectable cephalosporin composition with reasonable viscosity, resuspendability, and syringeability attributes for injection as an antibiotic for animals.Type: ApplicationFiled: March 5, 2020Publication date: April 28, 2022Inventors: Vijaya Bharti Joshi, Laibin Luo, Todd P. Foster
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Patent number: 10729698Abstract: The present disclosure relates generally to sol-gel polymer composites that comprise chitosan, a hydrophilic polymer, a gelation agent, and optional additional ingredients in a suitable medium. Advantageously, the sol-gel polymer composite can form a durable seal or strong solid in response to one or more physiological stimulus. The disclosure further relates to medical and veterinary uses of the composite, particularly, methods and delivery systems for reducing or preventing the incidence of a mammary disorder in a dairy animal. More particularly, the disclosure includes methods and sol-gel polymer composite compositions for creating a physical barrier on the teat surface or in the teat canal or cistern of a non-human animal for prophylactic treatment of mammary disorders such as mastitis wherein the sol-gel polymer creates a seal in response to one or more physiological stimulus.Type: GrantFiled: August 8, 2018Date of Patent: August 4, 2020Assignee: Zoetis Services LLCInventors: Sumitra Rajagopalan, Wilms Baille, Piotr Kujawa, Christopher A. Zook, Rebecca R. Quesnell, Dennis L. Huczek, Stephen L. Secreast, Laibin Luo, Tammy A. Sanders
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Patent number: 10561735Abstract: The instant invention relates to a solid product comprising a liquid biologically active agent which is intimately associated to a stabilizing agent; particularly a solid product that can be reconstituted to a clear, stable, stabilized nanodispersion or loaded micelles comprising a polymer as a stabilizing agent and a liquid, preferably water immiscible, biologically active agent. The instant invention is further directed toward a process for the production of the above solid product; particularly to micelles or nanodispersions produced by hydration of a cake or powder of the solid product, produced via an effective treatment of a stabilized solution comprising for example a polymer as a stabilizing agent, such as an amphiphilic block copolymer or a small molecular weight surfactant, loaded with a liquid biologically active agent, such as propofol, an optional additive, and a suitable solvent.Type: GrantFiled: November 20, 2017Date of Patent: February 18, 2020Assignees: Paladin Labs Inc., Paladin Labs Europe Limited, Paladin Labs (Barbados) Inc.Inventors: Francois Ravenelle, Sandra Gori, David Lessard, Laibin Luo, Dorothee Le Garrec, Damon Smith
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Patent number: 10350196Abstract: The invention describes a long-acting injectable veterinary composition comprising a spirocyclic isoxazoline, at least one biopolymer, and optionally, at least one veterinary acceptable-carrier, -solvent, -excipient, or any mixture thereof. The invention also includes a method of treating an animal with a parasitic infestation by administering the biopolymeric composition to the animal in need thereof, and a process for preparing the biopolymeric composition.Type: GrantFiled: September 26, 2014Date of Patent: July 16, 2019Assignee: Zoetis Services LLCInventors: Todd P. Foster, Laibin Luo
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Publication number: 20190030043Abstract: The present disclosure relates generally to sol-gel polymer composites that comprise chitosan, a hydrophilic polymer, a gelation agent, and optional additional ingredients in a suitable medium. Advantageously, the sol-gel polymer composite can form a durable seal or strong solid in response to one or more physiological stimulus. The disclosure further relates to medical and veterinary uses of the composite, particularly, methods and delivery systems for reducing or preventing the incidence of a mammary disorder in a dairy animal. More particularly, the disclosure includes methods and sol-gel polymer composite compositions for creating a physical barrier on the teat surface or in the teat canal or cistern of a non-human animal for prophylactic treatment of mammary disorders such as mastitis wherein the sol-gel polymer creates a seal in response to one or more physiological stimulus.Type: ApplicationFiled: August 8, 2018Publication date: January 31, 2019Inventors: Sumitra Rajagopalan, Wilms Baille, Piotr Kujawa, Christopher A. Zook, Rebecca R. Quesnell, Dennis L. Huczek, Stephen L. Secreast, Laibin Luo, Tammy A. Sanders
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Patent number: 10064870Abstract: The present disclosure relates generally to sol-gel polymer composites that comprise chitosan, a hydrophilic polymer, a gelation agent, and optional additional ingredients in a suitable medium. Advantageously, the sol-gel polymer composite can form a durable seal or strong solid in response to one or more physiological stimulus. The disclosure further relates to medical and veterinary uses of the composite, particularly, methods and delivery systems for reducing or preventing the incidence of a mammary disorder in a dairy animal. More particularly, the disclosure includes methods and sol-gel polymer composite compositions for creating a physical barrier on the teat surface or in the teat canal or cistern of a non-human animal for prophylactic treatment of mammary disorders such as mastitis wherein the sol-gel polymer creates a seal in response to one or more physiological stimulus.Type: GrantFiled: November 2, 2016Date of Patent: September 4, 2018Assignee: Zoetis Services LLCInventors: Sumitra Rajagopalan, Wilms Baille, Piotr Kujawa, Christopher A. Zook, Rebecca R. Quesnell, Dennis L. Huczek, Stephen L. Secreast, Laibin Luo, Tammy A. Sanders
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Publication number: 20180140706Abstract: The instant invention relates to a solid product comprising a liquid biologically active agent which is intimately associated to a stabilizing agent; particularly a solid product that can be reconstituted to a clear, stable, stabilized nanodispersion or loaded micelles comprising a polymer as a stabilizing agent and a liquid, preferably water immiscible, biologically active agent. The instant invention is further directed toward a process for the production of the above solid product; particularly to micelles or nanodispersions produced by hydration of a cake or powder of the solid product, produced via an effective treatment of a stabilized solution comprising for example a polymer as a stabilizing agent, such as an amphiphilic block copolymer or a small molecular weight surfactant, loaded with a liquid biologically active agent, such as propofol, an optional additive, and a suitable solvent.Type: ApplicationFiled: November 20, 2017Publication date: May 24, 2018Inventors: Francois Ravenelle, Sandra Gori, David Lessard, Laibin Luo, Dorothee Le Garrec, Damon Smith
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Publication number: 20170143786Abstract: An intravaginal formulation is provided, comprising a carboxylic acid in a n amount of 10-20% w/w of said formulation, an oleaginous base, having melting temperature between 30° C. and 38° C., GnRH or an analog thereof, in an amount equivalent to GnRH amount of between 10 ?g and 600 ?g. A method of inducing ovulation in a ruminant using the formulation is also provided.Type: ApplicationFiled: June 3, 2015Publication date: May 25, 2017Inventors: Kenneth L. Feenstra, Laibin Luo, Susan C. Sucheta, Nicholas A. Wicks, Karen P. Kolbasa
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Publication number: 20170119785Abstract: The present disclosure relates generally to sol-gel polymer composites that comprise chitosan, a hydrophilic polymer, a gelation agent, and optional additional ingredients in a suitable medium. Advantageously, the sol-gel polymer composite can form a durable seal or strong solid in response to one or more physiological stimulus. The disclosure further relates to medical and veterinary uses of the composite, particularly, methods and delivery systems for reducing or preventing the incidence of a mammary disorder in a dairy animal. More particularly, the disclosure includes methods and sol-gel polymer composite compositions for creating a physical barrier on the teat surface or in the teat canal or cistern of a non-human animal for prophylactic treatment of mammary disorders such as mastitis wherein the sol-gel polymer creates a seal in response to one or more physiological stimulus.Type: ApplicationFiled: November 2, 2016Publication date: May 4, 2017Inventors: SUMITRA RAJAGOPALAN, WILMS BAILLE, PIOTR KUJAWA, Christopher A. Zook, Rebecca R. Quesnell, Dennis L. Huczek, Stephen L. Secreast, Laibin Luo, Tammy A. Sanders
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Publication number: 20160235720Abstract: The invention describes a long-acting injectable veterinary composition comprising a spirocyclic isoxazoline, at least one biopolymer, and optionally, at least one veterinary acceptable-carrier, -solvent, -excipient, or any mixture thereof. The invention also includes a method of treating an animal with a parasitic infestation by administering the biopolymeric composition to the animal in need thereof, and a process for preparing the biopolymeric composition.Type: ApplicationFiled: September 26, 2014Publication date: August 18, 2016Inventors: Todd P. FOSTER, Laibin LUO
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Publication number: 20160193341Abstract: The instant invention relates to a solid product comprising a liquid biologically active agent which is intimately associated to a stabilizing agent; particularly a solid product that can be reconstituted to a clear, stable, stabilized nanodispersion or loaded micelles comprising a polymer as a stabilizing agent and a liquid, preferably water immiscible, biologically active agent. The instant invention is further directed toward a process for the production of the above solid product; particularly to micelles or nanodispersions produced by hydration of a cake or powder of the solid product, produced via an effective treatment of a stabilized solution comprising for example a polymer as a stabilizing agent, such as an amphiphilic block copolymer or a small molecular weight surfactant, loaded with a liquid biologically active agent, such as propofol, an optional additive, and a suitable solvent.Type: ApplicationFiled: September 3, 2015Publication date: July 7, 2016Inventors: Francois Ravenelle, Sandra Gori, David Lessard, Laibin Luo, Dorothee Le Garrec, Damon Smith
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Publication number: 20140323587Abstract: The instant invention relates to a solid product comprising a liquid biologically active agent which is intimately associated to a stabilizing agent; particularly a solid product that can be reconstituted to a clear, stable, stabilized nanodispersion or loaded micelles comprising a polymer as a stabilizing agent and a liquid, preferably water immiscible, biologically active agent. The instant invention is further directed toward a process for the production of the above solid product; particularly to micelles or nanodispersions produced by hydration of a cake or powder of the solid product, produced via an effective treatment of a stabilized solution comprising for example a polymer as a stabilizing agent, such as an amphiphilic block copolymer or a small molecular weight surfactant, loaded with a liquid biologically active agent, such as propofol, an optional additive, and a suitable solvent.Type: ApplicationFiled: December 19, 2013Publication date: October 30, 2014Applicants: PALADIN LABS INC., PALADIN LABS (BARBADOS) INC., PALADIN LABS EUROPE LIMITEDInventors: Francois Ravenelle, Sandra Gori, David Lessard, Laibin Luo, Dorothee Le Garrec, Damon Smith
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Publication number: 20140094486Abstract: The invention relates to novel crystalline forms of (2S)-2-tert-butoxy-2-(4-(2,3-dihydropyrano[4,3,2-de]quinolin-7-yl)-2-methylquinolin-3-yl)acetic acid, the hydrochloride salt thereof, novel crystalline forms of the hydrochloride salt, methods for the preparation thereof, pharmaceutical compositions thereof and their use in the treatment of Human Immunodeficiency Virus (HIV) infection.Type: ApplicationFiled: October 3, 2013Publication date: April 3, 2014Inventors: Zheng Jane LI, Zhibin LI, Laibin LUO, Thomas OFFERDAHL, Soojin KIM, Bing-Shiou YANG
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Publication number: 20120289606Abstract: The instant invention relates to a solid product comprising a liquid biologically active agent which is intimately associated to a stabilizing agent; particularly a solid product that can be reconstituted to a clear, stable, stabilized nanodispersion or loaded micelles comprising a polymer as a stabilizing agent and a liquid, preferably water immiscible, biologically active agent. The instant invention is further directed toward a process for the production of the above solid product; particularly to micelles or nanodispersions produced by hydration of a cake or powder of the solid product, produced via an effective treatment of a stabilized solution comprising for example a polymer as a stabilizing agent, such as an amphiphilic block copolymer or a small molecular weight surfactant, loaded with a liquid biologically active agent, such as propofol, an optional additive, and a suitable solvent.Type: ApplicationFiled: July 19, 2012Publication date: November 15, 2012Inventors: François Ravenelle, Sandra Gori, David Lessard, Laibin Luo, Dorothée Le Garrec, Damon Smith
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Patent number: 7838600Abstract: The instant invention provides a two-step polymerization process for preparing amphiphilic poly(N-vinyl-2-pyrrolidone), (PVP)-block-polyester copolymers and other diblock and triblock copolymers consisting of PVP as one block. The block copolymers of the invention can be used as vehicles for drug delivery.Type: GrantFiled: September 16, 2008Date of Patent: November 23, 2010Assignees: Labopharm, Inc., Labopharm Europe Limited, Labopharm (Barbados) LimitedInventors: Laibin Luo, David Lessard, Sandra Gori, Maxime Ranger, Yuan Wang, Julie Lafreniere, Jean-Francois Meunier, Genevieve Bibeau, Frederic Lebrun, Lu Wei Liu
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Publication number: 20090258071Abstract: The invention provides compositions and methods for the targeted, in particular, pH targeted, delivery of pharmaceutically active agents in mammals. The compositions comprise pH sensitive diblock copolymers, which permit the release of the pharmaceutically active agent when exposed to an environment having a particular pH. The compositions are particularly useful for the oral delivery of water insoluble pharmaceutically active agents.Type: ApplicationFiled: March 20, 2009Publication date: October 15, 2009Applicant: Labopharm, Inc.Inventors: David Lessard, Laibin Luo, Dorothee Le Garrec, Damon Smith
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Publication number: 20090012240Abstract: The instant invention provides a two-step polymerization process for preparing amphiphilic poly(N-vinyl-2-pyrrolidone), (PVP)-block-polyester copolymers and other diblock and triblock copolymers consisting of PVP as one block. The block copolymers of the invention can be used as vehicles for drug delivery.Type: ApplicationFiled: September 16, 2008Publication date: January 8, 2009Inventors: Laibin Luo, David Lessard, Sandra Gori, Maxime Ranger, Yuan Wang, Julie Lafreniere, Jean-Francois Meunier, Genevieve Bibeau, Frederic Lebrun, Lu Wei Liu
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Publication number: 20080027205Abstract: The instant invention provides a two-step polymerization process for preparing amphiphilic poly(N-vinyl-2-pyrrolidone), (PVP)-block-polyester copolymers and other diblock and triblock copolymers consisting of PVP as one block. The block copolymers of the invention can be used as vehicles for drug delivery.Type: ApplicationFiled: August 6, 2007Publication date: January 31, 2008Inventors: Laibin Luo, David Lessard, Sandra Gori, Maxime Ranger, Yuan Wang, Julie Lafreniere, Jean-Francois Meunier, Genevieve Bibeau, Frederic Lebrun, Lu Liu