Abstract: The present invention provides a tissue closure device, comprising: a first clamping base and a second clamping base which may be opened/closed relatively and form an accommodation cavity after being closed; and a pouch assembly which may be driven to move in the accommodation cavity, wherein: the pouch assembly comprises a staple pusher, a pair of needle heads movably connected to the staple pusher, and a connection portion connected to the proximal ends of the pair of needle heads; and when the staple pusher moves from the proximal end to the distal end, the pair of needle heads pushes a tubular tissue located in the accommodation cavity to the distal end until the distal ends of the pair of needle heads are closed to close the tubular tissue into a purse string. A bundled purse string with a gathered center may be formed through the tissue closure device.

Abstract: A solid pharmaceutical composition containing a 1,3,5-triazine derivative or a pharmaceutically acceptable salt thereof and a preparation method therefor. In particular, involved are a solid pharmaceutical composition containing 4-(tert-butoxyamino)-6-(6-(trifluoromethyl)pyridin-2-yl)-N-(2-(trifluoromethyl)pyridin-4-yl)-1,3,5-triazine-2-amine or a pharmaceutically acceptable salt thereof and a preparation method therefor. The solid pharmaceutical composition has a good stability, a fast dissolution rate and a high bioavailability, and is suitable for clinical production and use.

Abstract: The present invention provides a tissue closure device, comprising: a first clamping base and a second clamping base which may be opened/closed relatively and form an accommodation cavity after being closed; and a pouch assembly which may be driven to move in the accommodation cavity, wherein: the pouch assembly comprises a staple pusher, a pair of needle heads movably connected to the staple pusher, and a connection portion connected to the proximal ends of the pair of needle heads; and when the staple pusher moves from the proximal end to the distal end, the pair of needle heads pushes a tubular tissue located in the accommodation cavity to the distal end until the distal ends of the pair of needle heads are closed to close the tubular tissue into a purse string. A bundled purse string with a gathered center may be formed through the tissue closure device.