Patents by Inventor Lain Roberts

Lain Roberts has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHOD OF TREATING DISEASES ASSOCIATED WITH MYD88 PATHWAYS USING CRISPR-GNDM SYSTEM
    Publication number: 20210260170
    Abstract: The present invention provides a method of treating a disease associated with activated MYD88 signaling in a subject, including suppressing MYD88 expression in a subject by targeting an expression regulatory region of MYD88 gene by using a CRISPR-Guide Nucleotide Directed Modulation (GNDM), without affecting the expression of an adjacent ACAA1 gene. Also, provided is a CRISPR-GNDM system for suppressing MYD88, including expression comprising (a) a protein selected from the group consisting of dCas9 or dCpf1, a fusion protein of dCas9 or dCpf1 and Kruppel associated box (KRAB) and (b) a guide RNA (gRNA) targeting an expression regulatory region of MYD88 gene.
    Type: Application
    Filed: May 17, 2018
    Publication date: August 26, 2021
    Inventors: Tetsuya YAMAGATA, Yuanbo QIN, lain Robert THOMPSON, Haruhiko MORITA
  • METHOD OF TREATING DISEASES ASSOCIATED WITH ELEVATED KRAS EXPRESSION USING CRISPR-GNDM SYSTEM
    Publication number: 20190376088
    Abstract: The present invention provides a method of treating a disease associated with elevated KRAS activity or expression in a subject, comprising suppressing KRAS expression in the subject by targeting an expression regulatory region of KRAS gene using a CRISPR-Guide Nucleotide Directed Modulation (GNDM). Also, provided is a CRISPR-GNDM system for suppressing KRAS expression comprising (a) a protein selected from the group consisting of dCas9 or dCpf1, a fusion protein of dCas9 or dCpf1 and Kruppel associated box (KRAB), and (b) a guide nucleotide targeting an expression regulatory region of KRAS gene.
    Type: Application
    Filed: February 7, 2018
    Publication date: December 12, 2019
    Applicant: EdiGENE Corporation
    Inventors: Tetsuya YAMAGATA, Yuanbo QIN, Haruhiko MORITA, Talha AKBULUT, lain Robert THOMPSON
  • ADJUSTABLE SHAPE EARPHONE
    Publication number: 20120155689
    Abstract: This disclosure relates to an adjustable ear insert, such as an earbud style earphone, that may be inserted in a user's ear canal in a compact configuration and adjusted by a user to expand and fit snugly against the ear canal.
    Type: Application
    Filed: December 31, 2008
    Publication date: June 21, 2012
    Inventors: Allan Milodzikowski, Lain Roberts, Georg Aye, Jerry O'Leary, Michael J. Koss, Martin Thaler, Michael Pelland