Patents by Inventor Lain-Tze Lee

Lain-Tze Lee has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230242501
    Abstract: The present invention provides a novel compound for effectively preventing nerve damage and protecting nerves, and a preparation method thereof. Besides, the present invention also provides a pharmaceutical composition comprising the novel compound, and a use of the novel compound for preventing nerve damage and protecting nerves.
    Type: Application
    Filed: January 28, 2022
    Publication date: August 3, 2023
    Inventors: LAIN-TZE LEE, HUI-PING TSAI, YI-WEN LIN, SHU-FEN HUANG, Shih-Hung LIU, Chin-Wei LIU, PI-TSAN HUANG, MEI-HUI CHEN
  • Patent number: 11124472
    Abstract: The present invention discloses a novel 3-aryl-2-propen-1-one series derivative and the synthesis processes thereof. Besides, the present invention also discloses the series derivative as a pharmaceutical composition and their use for promoting myocardial regeneration.
    Type: Grant
    Filed: April 8, 2019
    Date of Patent: September 21, 2021
    Assignee: GENHEALTH PHARMA CO., LTD.
    Inventors: Lain-Tze Lee, Hui-Ping Tsai, Shu-Fen Huang, Yi-Wen Lin, Pi-Tsan Huang, Ying-Ying Wu, Mei-Hui Chen, Li-Jie Hsu
  • Publication number: 20200317602
    Abstract: The present invention discloses a novel 3-aryl-2-propen-1-one series derivative and the synthesis processes thereof. Besides, the present invention also discloses the series derivative as a pharmaceutical composition and their use for promoting myocardial regeneration.
    Type: Application
    Filed: April 8, 2019
    Publication date: October 8, 2020
    Applicant: GENHEALTH PHARMA CO., LTD.
    Inventors: Lain-Tze LEE, Hui-Ping TSAI, Shu-Fen HUANG, Yi-Wen LIN, Pi-Tsan HUANG, Ying-Ying WU, Mei-Hui CHEN, Li-Jie HSU
  • Patent number: 10137159
    Abstract: A method for treating liver fibrosis. The method includes administering to a subject suffering from liver fibrosis a pharmaceutically active extract obtained from a Boehmeria species. Also disclosed is a method for regenerating liver tissue and a method for improving a liver function.
    Type: Grant
    Filed: November 22, 2013
    Date of Patent: November 27, 2018
    Assignee: Industrial Technology Research Institute
    Inventors: Lain-Tze Lee, Ying-Chu Shih, Hui-Ping Tsai, Meng-Nan Lin, Wan-Chun Liu
  • Patent number: 9549958
    Abstract: An extract of Cynanchum sp. in use of arthritis treatment is provided. The extract of Cynanchum sp. and an active ingredient contained therein, antofine, are applicable to a method, pharmaceutical composition and dietary supplement for treatment of arthritis. A mass production of antofine from plant extracts is also provided.
    Type: Grant
    Filed: April 27, 2012
    Date of Patent: January 24, 2017
    Assignee: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
    Inventors: Jennline Sheu, Lain-Tze Lee, Ying-Chu Shih, Cheng-Yu Lee, Yi-Ching Lee, Jir-Mehng Lo, Tien-Soung Tong, Jui-Hung Yen, Kuo-Kuei Huang, Ying-Fei Tsai
  • Patent number: 9301944
    Abstract: The disclosure provides a method for treating hepatitis C, including: administering an effective amount of a proanthocyanidins oligomer to a subject in need, wherein the structure of the proanthocyanidins oligomer is shown as Formula (I): and in Formula (I), N is an integer of about 1-18.
    Type: Grant
    Filed: November 19, 2012
    Date of Patent: April 5, 2016
    Assignee: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
    Inventors: Lain-Tze Lee, Shau-Feng Chang, Cheng Lin, Shao-Chan Yin, Shu-Jiau Chiou
  • Patent number: 9289443
    Abstract: A pharmaceutical composition for preventing or treating hepatitis C is provided, including oleanolic acid derivatives as an active ingredient and a pharmaceutically acceptable carrier. A method for preventing or treating hepatitis C in a subject in need thereof is also provided by administering the subject the pharmaceutical composition given above.
    Type: Grant
    Filed: October 26, 2011
    Date of Patent: March 22, 2016
    Assignee: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
    Inventors: Lain-Tze Lee, Shau-Feng Chang, Zong-Keng Kuo, Hui-Ping Tsai
  • Patent number: 9060989
    Abstract: A method for treating or relieving inflammatory bowel disease (IBD) is provided, including administering an extract of Bupleurum as an active ingredient to a subject. The Bupleurum may be selected from the group consisting of Bupleurum krylovianum, Bupleurum chinense, Bupleurum commelynoideum, Bupleurum scorzonerifolium, Bupleurum triradiatum, Bupleurum falcatum, Bupleurum kaoi and a combination thereof.
    Type: Grant
    Filed: September 28, 2012
    Date of Patent: June 23, 2015
    Assignee: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
    Inventors: Ying-Chu Shih, Lain-Tze Lee, Nai-Yun Hu, Tien-Soung Tong
  • Patent number: 8815221
    Abstract: A composition used for skin whitening includes: an effective amount of spermidine derivative, wherein a structure of the spermidine derivative is shown as Structure (I): where R1-R5 individually includes H, OH, or OCH3 and at least one of R1-R5 is OH, and the spermidine derivative has tyrosinase inhibition activity; and a cosmetically or pharmaceutically acceptable vehicle, wherein the composition used for skin whitening whitens skin.
    Type: Grant
    Filed: August 5, 2010
    Date of Patent: August 26, 2014
    Assignee: Industrial Technology Research Institute
    Inventors: Lain-Tze Lee, Hui-Ping Tsai, Ling-Meei Tsay, Li-Syuan Jian, Chia-Mu Tu
  • Patent number: 8802662
    Abstract: The invention provides an anti-hepatitis C composition including: an effective amount of limonoid compound, wherein the structure of the limonoid compound is shown as Structure (I): where R1 comprises H or OAc and R2 comprises H or COCH(CH3)2; and a pharmaceutically acceptable carrier or salt, and the anti-hepatitis C composition is used for inhibiting hepatitis C virus or treating hepatitis C. The invention also provides a method for treating hepatitis C and a method for preparing a drug for inhibiting hepatitis C viruses or treating hepatitis C.
    Type: Grant
    Filed: October 4, 2009
    Date of Patent: August 12, 2014
    Assignee: Industrial Technology Research Institute
    Inventors: Lain-Tze Lee, Shau-Feng Chang, Hui-Ping Tsai, Zong-Keng Kuo, Chen-Fang Chung
  • Publication number: 20140134280
    Abstract: An extract of Cynanchum sp. in use of arthritis treatment is provided. The extract of Cynanchum sp. and an active ingredient contained therein, antofine, are applicable to a method, pharmaceutical composition and dietary supplement for treatment of arthritis. A mass production of antofine from plant extracts is also provided.
    Type: Application
    Filed: April 27, 2012
    Publication date: May 15, 2014
    Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
    Inventors: Jennline Sheu, Lain-Tze Lee, Ying-Chu Shih, Cheng-Yu Lee, Yi-Ching Lee, Jir-Mehng Lo, Tien-Soung Tong, Jui-Hung Yen, Kuo-Kuei Huang, Ying-Fei Tsai
  • Publication number: 20140079818
    Abstract: A method for treating liver fibrosis. The method includes administering to a subject suffering from liver fibrosis a pharmaceutically active extract obtained from a Boehmeria species. Also disclosed is a method for regenerating liver tissue and a method for improving a liver function.
    Type: Application
    Filed: November 22, 2013
    Publication date: March 20, 2014
    Applicant: Industrial Technology Research Institute
    Inventors: Lain-Tze Lee, Ying-Chu Shih, Hui-Ping Tsai, Meng-Nan Lin, Wan-Chun Liu
  • Patent number: 8597693
    Abstract: A pharmaceutical composition with an immunomodulating function is provided, including an extract of Bupleurum obtained by grinding the Bupleurum, adding the ground Bupleurum to a solvent and isolating the extract from the solvent, wherein the Bupleurum comprises Bupleurum krlovianum, Bupleurum longiradiatum, Bupleurum smithii, Bupleurum pusillum, Bupleurum longicaule, Bupleurum salicifolium, Bupleurum scorzonerifolium and Bupleurums with at least one of the nucleotide sequences selected from a group consisting of SEQ ID NOs. 1˜6 and a nucleotide sequence with no more than 1% of the nucleotide sequence divergences of SEQ ID NOs. 1˜6, or combinations thereof.
    Type: Grant
    Filed: July 1, 2010
    Date of Patent: December 3, 2013
    Assignee: Industrial Technology Research Institute
    Inventors: Ying-Chu Shih, Lain-Tze Lee, Bie-Shung Tsai, Jir-Mehng Lo, Tien-Soung Tong, Jenn-Line Sheu, Kuo-Kuei Huang, Ying-Fei Tsai, Yi-Ching Lee, Hui-Ju Liang, Jui-Hung Yen, Cheng-Yu Lee
  • Publication number: 20130123204
    Abstract: The disclosure provides a method for treating hepatitis B, including: administering an effective amount of proanthocyanidins wherein the formula of a monomer of the proanthocyanidins is shown as Formula (I): wherein R1 is OCH3, R2 is OH and R3 is H, or R1 is OH and R2 and R3 both are H, or R1 and R2 both are OH and R3 is H, or R1, R2 and R3 all are OH, and R4 is 3-(?)-OH, 3-(?)-OH, 3-(?)-O-sugar or 3-(?)-O-sugar. Bonding between adjacent monomers take place at C4, C8 Carbon-carbon bond or C2, C7 oxygen bond of A type or C4, C8 or C4, C6 Carbon-carbon bond of B type or C type of proanthocyanidins. And the polymerized number is from 2 to 30.
    Type: Application
    Filed: January 7, 2013
    Publication date: May 16, 2013
    Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
    Inventors: Lain-Tze LEE, Shau-Feng CHANG, Chia-Yu LIN, Hui-Yen WU, Shu-Feng CHEN, Jinun-Ban YEH
  • Publication number: 20120165279
    Abstract: A pharmaceutical composition for preventing or treating hepatitis C is provided, including oleanolic acid derivatives as an active ingredient and a pharmaceutically acceptable carrier. A method for preventing or treating hepatitis C in a subject in need thereof is also provided by administering the subject the pharmaceutical composition given above.
    Type: Application
    Filed: October 26, 2011
    Publication date: June 28, 2012
    Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
    Inventors: Lain-Tze Lee, Shau-Feng Chang, Zong-Keng Kuo, Hui-Ping Tsai
  • Publication number: 20120164241
    Abstract: A pharmaceutical composition prepared from a Boehmeria species. This composition can be used to improve liver function and treat liver disease, and promoting liver tissue regeneration.
    Type: Application
    Filed: December 27, 2010
    Publication date: June 28, 2012
    Applicant: Industrial Technology Research Institute(ITRI)
    Inventors: Lain-Tze Lee, Ying-Chu Shih, Hui-Ping Tsai, Meng-Nan Lin, Wan-Chun Liu
  • Publication number: 20120003250
    Abstract: A pharmaceutical composition with an immunomodulating function is provided, including an extract of Bupleurum obtained by grinding the Bupleurum, adding the ground Bupleurum to a solvent and isolating the extract from the solvent, wherein the Bupleurum comprises Bupleurum krlovianum, Bupleurum longiradiatum, Bupleurum smithii, Bupleurum pusillum, Bupleurum longicaule, Bupleurum salicifolium, Bupleurum scorzonerifolium and Bupleurums with at least one of the nucleotide sequences selected from a group consisting of SEQ ID NOs. 1˜6 and a nucleotide sequence with no more than 1% of the nucleotide sequence divergences of SEQ ID NOs. 1˜6, or combinations thereof.
    Type: Application
    Filed: July 1, 2010
    Publication date: January 5, 2012
    Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
    Inventors: Ying-Chu Shih, Lain-Tze Lee, Bie-Shung Tsai, Jir-Mehng Lo, Tien-Soung Tong, Jenn-Line Sheu, Kuo-Kuei Huang, Ying-Fei Tsai, Yi-Ching Lee, Hui-Ju Liang, Jui-Hung Yen, Cheng-Yu Lee
  • Publication number: 20120003342
    Abstract: A pharmaceutical composition for treating or relieving inflammatory bowel disease (IBD) is provided. The pharmaceutical composition includes an extract of Bupleurum as an active ingredient, in which the Bupleurum is selected from the group consisting of Bupleurum krylovianum, Bupleurum chinense, Bupleurum commelynoideum, Bupleurum scorzonerifolium, Bupleurum triradiatum, Bupleurum falcatum, Bupleurum kaoi and a combination thereof.
    Type: Application
    Filed: May 28, 2011
    Publication date: January 5, 2012
    Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
    Inventors: Ying-Chu Shih, Lain-Tze Lee, Nai-Yun Hu, Tien-Soung Tong
  • Publication number: 20110033403
    Abstract: A composition used for skin whitening includes: an effective amount of spermidine derivative, wherein a structure of the spermidine derivative is shown as Structure (I): where R1-R5 individually includes H, OH, or OCH3 and at least one of R1-R5 is OH, and the spermidine derivative has tyrosinase inhibition activity; and a cosmetically or pharmaceutically acceptable vehicle, wherein the composition used for skin whitening whitens skin.
    Type: Application
    Filed: August 5, 2010
    Publication date: February 10, 2011
    Inventors: Lain-Tze LEE, Hui-Ping TSAI, Ling- Meei TSAY, Li-Syuan JIAN, Chia-Mu TU
  • Publication number: 20100317637
    Abstract: The invention provides an anti-hepatitis C composition including: an effective amount of limonoid compound, wherein the structure of the limonoid compound is shown as Structure (I): where R1 comprises H or OAc and R2 comprises H or COCH(CH3)2; and a pharmaceutically acceptable carrier or salt, and the anti-hepatitis C composition is used for inhibiting hepatitis C virus or treating hepatitis C. The invention also provides a method for treating hepatitis C and a method for preparing a drug for inhibiting hepatitis C viruses or treating hepatitis C.
    Type: Application
    Filed: October 4, 2009
    Publication date: December 16, 2010
    Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
    Inventors: Lain-Tze LEE, Shau-Feng CHANG, Hui-Ping TSAI, Zong-Keng KUO, Chen-Fang CHUNG