Abstract: The sanitary shopping cart handle cover covers the handle of a cart. The sanitary shopping cart handle cover forms a sanitary barrier that prevents pathogens living on the handle with infecting a client using the cart. The sanitary shopping cart handle cover incorporates a primary structure, a plurality of gloves, and a pocket. The plurality of gloves and the pocket attach to the primary structure. The primary structure covers the handle. The primary structure forms a barrier that prevents the transfer of a pathogen from the handle to a client. The pocket forms a sanitary storage structure that allows a client to store a domestic article without placing the domestic article within the containment space of the cart. The plurality of gloves are worn on the hands of the client. The plurality of gloves form personal barriers that prevent the pathogens from reaching the hands of the client.