Patents by Inventor Laiping Xie

Laiping Xie has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Protein tyrosine phosphatase substrate-trapping double mutant and uses thereof
    Patent number: 8071348
    Abstract: The present invention provides protein tyrosine phosphatases (PTP) in which the invariant aspartate residue and the invariant glutamine residue are each replaced with a replacement amino acid residue, wherein the replacement residues together cause a reduction in catalytic rate (kcat) of the enzyme and an increase in substrate-binding affinity (Kd) of the enzyme. The present invention further provides methods for identifying a substrate of a PTP. Also provided are kits for identifying a substrate of a PTP. Additionally, the present invention provides methods for identifying an agent that alters interaction between a PTP and a substrate of the PTP. The invention also provides methods for reducing the activity of a substrate of a PTP.
    Type: Grant
    Filed: January 10, 2003
    Date of Patent: December 6, 2011
    Assignee: Albert Einstein College of Medicine of Yeshiva University
    Inventors: Zhong-Yin Zhang, Laiping Xie, Yan-Ling Zhang
  • Novel protein tyrosine phosphatase substrate-trapping double mutant and uses thereof
    Publication number: 20030170855
    Abstract: The present invention provides protein tyrosine phosphatases (PTP) in which the invariant aspartate residue and the invariant glutamine residue are each replaced with a replacement amino acid residue, wherein the replacement residues together cause a reduction in catalytic rate (kcat) of the enzyme and an increase in substrate-binding affinity (Kd) of the enzyme. The present invention further provides methods for identifying a substrate of a PTP. Also provided are kits for identifying a substrate of a PTP. Additionally, the present invention provides methods for identifying an agent that alters interaction between a PTP and a substrate of the PTP. The invention also provides methods for reducing the activity of a substrate of a PTP.
    Type: Application
    Filed: January 10, 2003
    Publication date: September 11, 2003
    Inventors: Zhong-Yin Zhang, Laiping Xie, Yan-Ling Zhang