Patents by Inventor Lajos Deak

Lajos Deak has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for extracting a macrolide from biomatter
    Patent number: 7432074
    Abstract: Provided is a method for obtaining a macrolide, especially tacrolimus, from biomatter.
    Type: Grant
    Filed: February 12, 2003
    Date of Patent: October 7, 2008
    Assignee: TEVA Gyógyszergyár Zártkörüen MüködöRészvénytársaság
    Inventors: Vilmos Keri, Lajos Deak, Csaba Szabo
  • Process for the isolation and purification of mevinolin
    Publication number: 20060223150
    Abstract: In a process for preparing mevinolin by fermentation of a biomass in a fermentation liquor, which includes dissolving mevinolin from the biomass into the fermentation liquor, and separating the biomass from the fermentation liquor to obtain a separated fermentation liquor, separating the mevinolin from the separated fermentation liquor, and recovering the end product, the improvement which comprises carrying out the dissolving at a pH between about 7.5 and about 10, and the separating of the mevinolin is carried out at a pH between about 4.5 and about 1.
    Type: Application
    Filed: May 10, 2004
    Publication date: October 5, 2006
    Inventors: Vilmos Keri, Eva Ilkoy, Irma Hogye, Antonia Jekkel, Ilonu Bagdi, Gabor Ambrus, Attila Jakab, Attilla Andor, Lajos Deak, Istvan Szabo, Janos Balint, Zsuzsanna Scheidl, Etelka Deli, Gyula Horvath, Csaba Szabo, Ildiko Lang, Imre Szekely, Imre Moravcsik, Vera Kovacs, Szabolcs Matyas, Zsuasanna Sztaray, Laszlo Eszenyi
  • Pravastatin sodium substantially free of pravastatin lactone and EPI-pravastatin, and compositions containing same
    Publication number: 20050215636
    Abstract: The present invention provides pravastatin sodium substantially free of pravastatin lactone and epiprava, the C-6 epimer of pravastatin. The present invention further provides a novel process for recovering pravastatin sodium from a fermentation broth in such high purity. The process includes the stages of forming an solution of the compound by extraction, obtaining an ammonium salt of pravastatin from the solution, purifying the ammonium salt of the compound and transposing the salt of the compound to pravastatin sodium.
    Type: Application
    Filed: May 16, 2005
    Publication date: September 29, 2005
    Inventors: Vilmos Keri, Lajos Deak, Ilona Forgacs, Csaba Szabo, Arvai Nagyne
  • Pravastatin sodium substantially free of pravastatin lactone and epi-pravastatin, and compositions containing same
    Patent number: 6936731
    Abstract: The present invention provides pravastatin sodium substantially free of pravastatin lactone and epiprava, the C-6 epimer of pravastatin. The present invention further provides a novel process for recovering pravastatin sodium from a fermentation broth in such high purity. The process includes the stages of forming an solution of the compound by extraction, obtaining an ammonium salt of pravastatin from the solution, purifying the ammonium salt of the compound and transposing the salt of the compound to pravastatin sodium.
    Type: Grant
    Filed: October 5, 2001
    Date of Patent: August 30, 2005
    Assignee: TEVA Gyógyszergyár Részvénytársaság
    Inventors: Vilmos Keri, Lajos Deak, Ilona Forgacs, Csaba Szabo, Arvai Edit Nagyne
  • Ion-exchange filtration of fermentation broth
    Publication number: 20050003499
    Abstract: The invention encompasses a process for purifying a fermentation broth by providing a fermentation broth; adjusting the pH of the fermentation broth; isolating a filtrate from the fermentation broth; and passing the filtrate through a cation-exchange resin to obtain a purified filtrate.
    Type: Application
    Filed: June 9, 2004
    Publication date: January 6, 2005
    Inventors: Vilmos Keri, Istvan Melczer, Lajos Deak, Krisztian Szeles
  • Process for the isolation and purification of mevinolin
    Patent number: 6812007
    Abstract: In a process for preparing mevinolin by fermentation of a biomass in a fermentation liquor, which includes dissolving mevinolin from the biomass into the fermentation liquor, and separating the biomass from the fermentation liquor to obtain a separated fermentation liquor, separating the mevinolin from the separated fermentation liquor, and recovering the end product, the improvement which comprises carrying out the dissolving at a pH between 7.5 and about 10, and the separating of the mevinolin is carried out at a pH between about 4.5 and about 1.
    Type: Grant
    Filed: April 19, 2000
    Date of Patent: November 2, 2004
    Inventors: Vilmos Kéri, Irma Högye, Antónia Jekkel, Ilona Bagdi, Gábor Ambrus, Attila Jakab, Attila Andor, Lajos Deák, István Szabó, János Bálint, Zsuzsanna Scheidl, Etelka Deli, Gyula Horváth, Csaba Szabó, Ildikó Láng, Imre Székely, Imre Moravcsik, Vera Kovács, Szabolcs Mátyás, Zsuzsanna Sztáray, László Eszenyi, Éva Ilköy
  • Process for recovering statin compounds from a fermentation broth
    Publication number: 20040115781
    Abstract: A novel process for recovering a compound from a fermentation broth that includes the stages of forming an enriched solution of the compound by extraction, obtaining a salt of the compound from the enriched solution, purifying a salt of the compound and trans-salifying the salt of the compound to a metal salt of the compound is disclosed.
    Type: Application
    Filed: November 5, 2003
    Publication date: June 17, 2004
    Inventors: Vilmos Keri, Lajos Deak, Ilona Forgacs, Csaba Szabo, Edit Arvai Nagyne
  • Purification process
    Patent number: 6706192
    Abstract: Object of the invention is a process for the chromatographic purification of cyclosporin A from a crude product containing cyclosporin complex by using a column filled with silica gel and by the application of multistep chromatography with a column filled with normal phase silica gel and by a solvent mixture containing toluene as the major component.
    Type: Grant
    Filed: May 15, 2002
    Date of Patent: March 16, 2004
    Assignee: Biogal Gyogyszergyar Rt.
    Inventors: Vilmos Kéri, Ärvai Nagyné, Lajos Deák, Györgyné Makó, Istvánné Miskolczy
  • Process for recovering statin compounds from a fermentation broth
    Patent number: 6689590
    Abstract: A composition comprising pravastatin sodium substantially free of pravastatin lactone is described.
    Type: Grant
    Filed: July 23, 2002
    Date of Patent: February 10, 2004
    Assignee: Biogal Gyogyszergyar Rt.
    Inventors: Vilmos Keri, Lajos Deak, Iiona Forgacs, Csaba Szabo, Edit Arvai Nagyne
  • Method for extracting a macrolide from biomatter
    Publication number: 20030166924
    Abstract: Provided is a method for obtaining a macrolide, especially tacrolimus, from biomatter.
    Type: Application
    Filed: February 12, 2003
    Publication date: September 4, 2003
    Inventors: Vilmos Keri, Lajos Deak, Csaba Szabo
  • Process for recovering statin compounds from a fermentation broth
    Publication number: 20020187531
    Abstract: A novel process for recovering a compound from a fermentation broth that includes the stages of forming an enriched solution of the compound by extraction, obtaining a salt of the compound from the enriched solution, purifying a salt of the compound and trans-salifying the salt of the compound to a metal salt of the compound is disclosed.
    Type: Application
    Filed: July 23, 2002
    Publication date: December 12, 2002
    Inventors: Vilmos Keri, Lajos Deak, Iiona Forgacs, Csaba Szabo, Edit Arvai Nagyne
  • Method for purification of acarbose
    Publication number: 20020183262
    Abstract: The present invention relates to a novel process for the preparation of acarbose. Said process comprises the steps of: 1) acidifying a fermentation broth containing an acarbose; 2) removing particulates from the fermentation broth; 3) adsorbing the acarbose on a cation-exchanger in the presence of an anion of a weak acid; 4) eluting the acarbose from the cation-exchanger with at least one of a sodium chloride solution and a salt solution; 5) precipitating the acarbose with a solvent; and 6) recovering the precipitated acarbose.
    Type: Application
    Filed: January 30, 2002
    Publication date: December 5, 2002
    Inventors: Vilmos Keri, Lajos Deak
  • Purification process
    Publication number: 20020162789
    Abstract: Object of the invention is a process for the chromatographic purification of cyclosporin A from a crude product containing cyclosporin complex by using a column filled with silica gel and by the application of multistep chromatography with a column filled with normal phase silica gel and by a solvent mixture containing toluene as the major component.
    Type: Application
    Filed: May 15, 2002
    Publication date: November 7, 2002
    Inventors: Vilmos Keri, Arvai Edit Nagyne, Lajos Deak, Gyorgyne Mako, Istvanne Miskolczy
  • Process for recovering statin compounds from a fermentation broth
    Patent number: 6444452
    Abstract: A novel process for recovering a compound from a fermentation broth that includes the stages of forming an enriched solution of the compound by extraction, obtaining a salt of the compound from the enriched solution, purifying a salt of the compound and trans-salifying the salt of the compound to a metal salt of the compound is disclosed.
    Type: Grant
    Filed: November 28, 2000
    Date of Patent: September 3, 2002
    Assignee: Biogal Gyogyszergyar Rt.
    Inventors: Vilmos Keri, Lajos Deak, Ilona Forgacs, Csaba Szabo, Edit Arvai Nagyne
  • Method for purification of acarbose
    Publication number: 20020111320
    Abstract: The present invention relates to a novel process for the preparation of acarbose. Said process comprises the steps of: 1) acidifying a fermentation broth containing an acarbose; 2) removing particulates from the fermentation broth; 3) adsorbing the acarbose on a cation-exchanger in the presence of an anion of a weak acid; 4) eluting the acarbose from the cation-exchanger with at least one of hydrochloric acid and the weak acid; 5) precipitating the acarbose with a solvent; and 6) separating the acarbose.
    Type: Application
    Filed: August 7, 2001
    Publication date: August 15, 2002
    Inventors: Vilmos Keri, Lajos Deak
  • Purification process
    Patent number: 6423233
    Abstract: Object of the invention is a process for the chromatographic purification of cyclosporin A from a crude product containing cyclosporin complex by using a column filled with silica gel and by the application of multistep chromatography with a column filled with normal phase silica gel and by a solvent mixture containing toluene as the major component.
    Type: Grant
    Filed: August 15, 2000
    Date of Patent: July 23, 2002
    Assignee: Biogal Gyogyszergyar Rt.
    Inventors: Vilmos Kéri, Árvai Edit Nagyné, Lajos Deák, Györgyné Makó, Istvánné Miskolczy
  • Pravastatin sodium substantially free of pravastatin lactone and epi-pravastatin, and compositions containing same
    Publication number: 20020082295
    Abstract: The present invention provides pravastatin sodium substantially free of pravastatin lactone and epiprava, the C-6 epimer of pravastatin. The present invention further provides a novel process for recovering pravastatin sodium from a fermentation broth in such high purity. The process includes the stages of forming an solution of the compound by extraction, obtaining an ammonium salt of pravastatin from the solution, purifying the ammonium salt of the compound and transposing the salt of the compound to pravastatin sodium.
    Type: Application
    Filed: October 5, 2001
    Publication date: June 27, 2002
    Inventors: Vilmos Keri, Lajos Deak, Ilona Forgacs, Csaba Szabo, Arvai Edit Nagyne
  • Method of purifying statins from a fermentation broth
    Patent number: 6387258
    Abstract: A process for purifying statin compounds from a fermentation broth by extraction and crystallization is disclosed. A fermentation broth is subjected to a pretreatment procedure which involves an alkaline pretreatment and an alkaline purification. Following the pretreatment procedure, the statin compound is extracted under acidic conditions into a hydrophobic solvent and purified by crystallization. The organic extraction solvent is concentrated and then extracted with a mild base. The statin compound is then purified by crystallization.
    Type: Grant
    Filed: January 25, 2001
    Date of Patent: May 14, 2002
    Assignee: Biogal Gyogyszergyar Rt.
    Inventors: Vilmos Keri, Lajos Deak, Iiona Forgacs