Patents by Inventor Lajos Gera

Lajos Gera has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Anti-cancer compounds
    Patent number: 6388054
    Abstract: The present invention provides compounds useful to inhibit tumor growth and to induce apoptosis. In general, the anti-cancer agents (ACA) are described by the formula: [ACA]n-X  [Formula I] wherein X is a linker group having 2-5 functional groups or is absent, n=1, and ACA is selected from the group consisting of Formula II, Formula III, Formula IV, Formula V, and Formula VI, as described herein. Other compounds described herein are defined by the Formula VII, as described herein.
    Type: Grant
    Filed: August 19, 1999
    Date of Patent: May 14, 2002
    Inventors: John M. Stewart, Daniel C. F. Chan, Lajos Gera, Eunice York, Paul Bunn
  • Bradykinin antagonists containing pentafluorophenylalanine
    Patent number: 5935932
    Abstract: The present invention provides bradykin antagonists containing pentafluorophenylalanine which are therapeutically useful. Moreover, the present invention provides methods to antagonize bradykinin receptors in a mammal in need of such antagonism, comprising administering a bradykinin antagonist containing pentafluorophenylalanine. Also provided are methods to treat inflammation in a mammal in need of such inhibition, comprising administering a bradykinin antagonist containing pentafluorophenylalanine. Lastly, a method to treat cancer in a mammal in need of such inhibition, comprising administering a bradykinin antagonist containing pentafluorophenylalanine.
    Type: Grant
    Filed: June 12, 1998
    Date of Patent: August 10, 1999
    Assignee: University Technology Corporation
    Inventors: John M. Stewart, Lajos Gera
  • Cytolytic bradykinin antagonists
    Patent number: 5849863
    Abstract: The present invention provides bradykinin antagonists effective to inhibit cancer cell growth. Also provided are methods of inhibiting lung cancer cell growth by administering a therapeutically effective amount of a dimerized bradykinin antagonist.
    Type: Grant
    Filed: September 8, 1995
    Date of Patent: December 15, 1998
    Assignees: University of Colorado, Cortech, Inc.
    Inventors: John M. Stewart, Daniel C. Chan, Eric T. Whalley, Lajos Gera
  • Des-Arg.sup.9 -BK antagonists
    Patent number: 5834431
    Abstract: The present invention provides des-Arg.sup.9 bradykinin analogs which are selective B1 receptor antagonists.
    Type: Grant
    Filed: September 8, 1995
    Date of Patent: November 10, 1998
    Assignees: Cortech, Inc., University of Colorado
    Inventors: John M. Stewart, Eric T. Whalley, Lajos Gera
  • Bradykinin antagonist peptides containing indane-substituted amino acids
    Patent number: 5648336
    Abstract: The present invention pertains to modified bradykinin antagonist peptides of the formula X-A.sup.0 -B.sup.1 -C.sup.2 -D.sup.3 -E.sup.4 -F.sup.5 -G.sup.6 -H.sup.7 -J.sup.8 -K.sup.9, where at least one of F.sup.5, H.sup.7 and J.sup.8 is an indane substituted amino acids.
    Type: Grant
    Filed: November 18, 1994
    Date of Patent: July 15, 1997
    Assignee: University of Colorado
    Inventors: John M. Stewart, Lajos Gera, Eric T. Whalley
  • 5,6-Dihydropyrimidin-4(3H)one derivatives, and antiedema compositions and methods employing them
    Patent number: 4113868
    Abstract: An antiedema compound of the formula: ##STR1## in which R.sup.1 is methyl, ethyl, cyclohexyl, phenyl, m-tolyl, p-tolyl, p-tert-butylphenyl, m-trifluoromethylphenyl, m-fluorophenyl, p-fluorophenyl, m-chlorophenyl, p-chlorophenyl, m-bromophenyl, p-bromophenyl, o-hydroxyphenyl, p-methoxyphenyl, p-nitrophenyl, benzyl, p-chlorobenzyl, m,p-dimethoxybenzyl, and o-pyridyl;R.sup.2 is hydrogen, p-tolyl, p-ethoxyphenyl, m-pyridyl, methyl or phenyl; andn is 1, 2 or 3And a process for the preparation thereof are disclosed.
    Type: Grant
    Filed: September 29, 1976
    Date of Patent: September 12, 1978
    Assignee: Chinoin Gyogyszer es Vegyeszeti Termekek Gyara R.T.
    Inventors: Gabor Bernath, Lajos Gera, Gyorgy Gondos, Zoltan Ecsery, Judit Hermann nee Voros, Matyas Szentivanyi, Erzsebet Janvari, nee Kanyo