Abstract: The invention relates to novel peptides of formula (I),A-Try-B-Asp-Phg-NH.sub. 2 (I)whereinA is tert.-butoxycarbonyl-aminooxy-acyl, benzyloxycarbonyl-aminooxy-acyl, (aminooxy)-acyl or E-aminooxy-acyl, wherein E is benzoyl or straight-chained or branched C.sub.1-5 aliphatic acyl, andB represents methionyl, leucyl, norleucyl, norvalyl or 2-amino-decanoyl,or acid addition salts or complexes thereof. The novel compounds according to the invention exert gastrin effects and can be applied to advantage in the diagnostics and therapy. The novel compounds of formula (I) are prepared according to the invention by reacting a tetrapeptideamide of formula (II),H-Try-B-Asp-Phg-NH.sub. 2 (II)wherein B is as defined above, with an (aminooxy)-acyl containing compound of the general formula A.sub.1 -X, whereinA.sub.1 has the same meanings as A with the exception of the (aminooxy)-acyl, andX is hydroxy group, halogen, pivaloyloxy, a group of the formula R--O--CO.sub.

Abstract: Angiotensin II analog of the formula IX-Arg-Val-Tyr-Ile-His-Pro-Y (I)whereinX is a radical derived from an aliphatic .alpha.-aminooxy-carboxylic acid andY is a radical derived from an aliphatic .alpha.-amino-carboxylic acid,and acid addition salts and complexes thereof with antagonistic properties useful in the diagnosis and treatment of hypertensions depending on renin.

Abstract: Peptides of the formula:A--Trp--B--Asp--Phe--NH--Ywherein A is tert.-butoxycarbonyl-aminooxy-acyl, benzyloxycarbonyl-aminooxy-acyl, (aminooxy)-acyl, or E-aminooxy-acyl, wherein E is benzoyl or straight-chain or branched C.sub.1-5 aliphatic acyl, B is methionyl, leucyl, norleucyl, norvalyl or 2-amino-decanoyl, and Y is hydrogen or carboxymethoxy, and pharmaceutically acceptable acid-addition salts or complexes thereof have gastric-acid secretion increasing effects.

Abstract: An N-substituted carbonyl tetrahydrobenzodiazepines having ethoxycarbonyl, formyl, carbamoyl or methyl carbamoyl as the N.sup.4 substituent.

Abstract: Vasodilatory eburnamine-type alkaloid esters of the formula (I) ##STR1## and salts and quaternary derivatives thereof, wherein X.about.Y REPRESENTS A =CH=CH- or ##STR2## R represents a C.sub.1-6 alkoxycarbonyl group optionally substituted with a hydroxy group or with a halogen atom, further an alkenyloxycarbonyl, aryloxycarbonyl, aralkoxycarbonyl group or an acylated primary alcohol group, especially apovincaninic acid ethyl ester, have been prepared by various methods of esterification.

Abstract: New benzodiazepine derivatives of the formula (I), ##STR1## wherein R.sub.1 stands for halogen, trifluoromethyl, nitro or amino,R.sub.2 stands for hydrogen or alkyl, andR.sub.3 stands for nitroso, amino, alkylideneamino, substituted alkylideneamino, aralkylideneamino, substituted aralkylideneamino, acylamido or substituted acylamido.The new compounds possess remarkable enzyme-inducing effects and exert only moderate central nervous activities.

Abstract: The invention relates to the preparation of biologically active polypeptides containing the aspartyl group, particularly an aspartyl-glycine moiety, using the active-ester technique.According to the method of the invention, human adrenocorticotropic hormone and its fragments characteristic to the individual species, as well as the blocked derivatives of such compounds are prepared by the pentafluorophenol method, i.e., the carboxy group of the acylating component is activated by converting it into pentafluorophenyl ester in the coupling reaction carried out with blocked peptides containing the aspartyl group or an aspartylglycine moiety. The acylation is carried out preferably using equimolar quantities of the respective reactants. The free peptides obtained after removing the blocking groups can be converted into their acid addition salts or pharmaceutically acceptable complexes or condensates.Human adrenocorticotropic hormone and its derivatives are valuable substances of therapeutical activity.