Patents by Inventor Lake Ee Khaw

Lake Ee Khaw has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Polyketides and Their Synthesis and Use
    Publication number: 20080287483
    Abstract: The rapamycin gene cluster is an example of a gene cluster which includes a gene (rapL) leading to the formation of a precursor compound (pipecolic acid, in this case) which is required for inclusion in the larger product (rapamycin) produced by the enzymes encoded by the cluster. We have produced a mutant strain containing a rapamycin gene cluster in which the rapL gene is disabled. The strain does not naturally produce rapamycin but does so if fed with pipecolic acid. By feeding with alternative carboxylic acids we have produced variants of rapamycins. Tests have shown biological activity.
    Type: Application
    Filed: May 29, 2008
    Publication date: November 20, 2008
    Inventors: Peter Francis Leadlay, James Staunton, Lake Ee Khaw
  • Polyketides and their synthesis and use
    Patent number: 7381546
    Abstract: The rapamycin gene cluster is an example of a gene cluster which includes a gene (rapL) leading to the formation of a precursor compound (pipecolic acid, in this case) which is required for inclusion in the larger product (rapamycin) produced by the enzymes encoded by the cluster. We have produced a mutant strain containing a rapamycin gene cluster in which the rapL gene is disabled. The strain does not naturally produce rapamycin but does so if fed with pipecolic acid. By feeding with alternative carboxylic acids we have produced variants of rapamycins. Tests have shown biological activity.
    Type: Grant
    Filed: January 10, 2006
    Date of Patent: June 3, 2008
    Assignee: Biotica Technology Limited
    Inventors: Peter Francis Leadlay, James Staunton, Lake Ee Khaw
  • Polyketides and their synthesis and use
    Patent number: 7018808
    Abstract: The rapamycin gene cluster is an example of a gene cluster which includes a gene (rapL) leading to the formation of a precursor compound (pipecolic acid, in this case) which is required for inclusion in the larger product (rapamycin) produced by the enzymes encoded by the cluster. We have produced a mutant strain containing a rapamycin gene cluster in which the rapL gene is disabled. The strain does not naturally produce rapamycin but does so if fed with pipecolic acid. By feeding with alternative carboxylic acids we have produced variants of rapamycins. Tests have shown biological activity.
    Type: Grant
    Filed: December 2, 2002
    Date of Patent: March 28, 2006
    Assignee: Biotica Technology Limited
    Inventors: Peter Francis Leadlay, James Staunton, Lake Ee Khaw
  • Polyketides and their synthesis and use
    Publication number: 20030104585
    Abstract: The rapamycin gene cluster is an example of a gene cluster which includes a gene (rapL) leading to the formation of a precursor compound (pipecolic acid, in this case) which is required for inclusion in the larger product (rapamycin) produced by the enzymes encoded by the cluster. We have produced a mutant strain containing a rapamycin gene cluster in which the rapL gene is disabled. The strain does not naturally produce rapamycin but does so if fed with pipecolic acid. By feeding with alternative carboxylic acids we have produced variants of rapamycins. Tests have shown biological activity.
    Type: Application
    Filed: December 2, 2002
    Publication date: June 5, 2003
    Inventors: Peter Francis Leadlay, James Staunton, Lake Ee Khaw