Patents by Inventor Lakmal W. Boteju

Lakmal W. Boteju has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of treating ulcerative colitis
    Patent number: 8404732
    Abstract: Methods of treating and managing ulcerative colitis, using imidazole-based compounds that inhibit S1P lyase, are disclosed.
    Type: Grant
    Filed: January 4, 2012
    Date of Patent: March 26, 2013
    Assignee: Lexicon Pharmaceuticals, Inc.
    Inventors: David J. Augeri, Jeffrey Bagdanoff, Lakmal W. Boteju, Kenneth G. Carson, Theodore C. Jessop, Spencer David Kimball
  • METHODS OF TREATING ULCERATIVE COLITIS
    Publication number: 20130005775
    Abstract: Methods of treating and managing ulcerative colitis, using imidazole-based compounds that inhibit S1P lyase, are disclosed.
    Type: Application
    Filed: January 4, 2012
    Publication date: January 3, 2013
    Applicant: LEXICON PHARMACEUTICALS, INC.
    Inventors: David J. Augeri, Jeffrey Bagdanoff, Lakmal W. Boteju, Kenneth G. Carson, Theodore C. Jessop, Spencer David Kimball
  • Methods of treating rheumatoid arthritis
    Patent number: 8093267
    Abstract: Imidazole-based compounds, compositions comprising them, and methods of their use for the treatment, prevention and management of inflammatory and autoimmune diseases and disorders are disclosed.
    Type: Grant
    Filed: December 1, 2009
    Date of Patent: January 10, 2012
    Assignee: Lexicon Pharmaceuticals, Inc.
    Inventors: David J. Augeri, Jeffrey Bagdanoff, Lakmal W. Boteju, Kenneth G. Carson, Theodore C. Jessop, Spencer David Kimball
  • METHODS OF TREATING RHEUMATOID ARTHRITIS
    Publication number: 20100076030
    Abstract: Imidazole-based compounds, compositions comprising them, and methods of their use for the treatment, prevention and management of inflammatory and autoimmune diseases and disorders are disclosed.
    Type: Application
    Filed: December 1, 2009
    Publication date: March 25, 2010
    Applicant: LEXICON PHARMACEUTICALS, INC.
    Inventors: David J. Augeri, Jeffrey Bagdanoff, Lakmal W. Boteju, Kenneth G. Carson, Theodore C. Jessop, Spencer David Kimball
  • Imidazole-based compounds, compositions comprising them and methods of their use
    Patent number: 7649098
    Abstract: Imidazole-based compounds, compositions comprising them, and methods of their use for the treatment, prevention and management of inflammatory and autoimmune diseases and disorders are disclosed.
    Type: Grant
    Filed: January 25, 2007
    Date of Patent: January 19, 2010
    Assignee: Lexicon Pharmaceuticals, Inc.
    Inventors: David J. Augeri, Jeffrey Bagdanoff, Lakmal W. Boteju, Kenneth G. Carson, Theodore C. Jessop, Spencer David Kimball
  • Use of GAL3 receptor antagonists for the treatment of depression and/or anxiety and compounds useful in such methods
    Publication number: 20090318504
    Abstract: This invention is directed to pyrimidine and indolone derivatives which are selective antagonists for the GAL3 receptor. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention also provides a pharmaceutical composition made by combining a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention further provides a process for making a pharmaceutical composition comprising combining a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention also provides a method of treating a subject suffering from depression and/or anxiety which comprises administering to the subject an amount of a compound of the invention effective to treat the subject's depression and/or anxiety.
    Type: Application
    Filed: December 15, 2008
    Publication date: December 24, 2009
    Inventors: Thomas P. Blackburn, Michael J. Konkel, Lakmal W. Boteju, Ian Jamie Talisman, John M. Wetzel, Mathivanan Packiarajan, Heidi Chen, Hermo Jimenez
  • Use of GAL3 antagonist for treatment of depression and/or anxiety and compounds useful in such methods
    Patent number: 7465750
    Abstract: This invention is directed to pyrimidine and indolone derivatives which are selective antagonists for the GAL3 receptor. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention also provides a pharmaceutical composition made by combining a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention further provides a process for making a pharmaceutical composition comprising combining a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention also provides a method of treating a subject suffering from depression and/or anxiety which comprises administering to the subject an amount of a compound of the invention effective to treat the subject's depression and/or anxiety.
    Type: Grant
    Filed: September 6, 2006
    Date of Patent: December 16, 2008
    Assignee: H. Lundbeck A/S
    Inventors: Thomas P. Blackburn, Michael J. Konkel, Lakmal W. Boteju, Ian Jamie Talisman, John M. Wetzel, Mathivanan Packiarajan, Heidi Chen, Hermo Jimenez
  • Use of GAL3 antagonist for treatment of depression
    Publication number: 20040127502
    Abstract: This invention is directed to pyrimidine and indolone derivatives which are selective antagonists for the GAL3 receptor. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention also provides a pharmaceutical composition made by combining a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention further provides a process for making a pharmaceutical composition comprising combining a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention also provides a method of treating a subject suffering from depression and/or anxiety which comprises administering to the subject an amount of a compound of the invention effective to treat the subject's depression and/or anxiety.
    Type: Application
    Filed: November 26, 2003
    Publication date: July 1, 2004
    Applicant: Synaptic Pharmaceutical Corporation
    Inventors: Thomas P. Blackburn, Michael J. Konkel, Lakmal W. Boteju, Ian Jamie Talisman, John M. Wetzel, Mathivana Packiarajan, Heidi Chen, Hermo Jimenez
  • Compounds for the treatment of pain
    Publication number: 20030176314
    Abstract: This invention provides methods of treating pain, urinary incontinence and other abnormalities mediated by a NPFF receptor, which comprises administering to a subject a therapeutically effective amount of a chemical compound which acts at the NPFF1 receptor, the NPFF2 receptor, or at both the NPFF1 and NPFF2 receptors.
    Type: Application
    Filed: September 24, 2002
    Publication date: September 18, 2003
    Inventors: Carlos C. Forray, Joel Kawakami, Michael J. Konkel, Lakmal W. Boteju, John M. Wetzel, Stewart A. Noble, Honghe Wan
  • Molecules specific for NPFF receptors and uses thereof
    Publication number: 20030144310
    Abstract: This invention provides a compound having the structure: 1
    Type: Application
    Filed: September 24, 2002
    Publication date: July 31, 2003
    Inventors: Lakmal W. Boteju, Michael J. Konkel, Joel K. Kawakami, John Wetzel
  • Guanidines which are agonist/antagonist ligands for neuropeptide FF (NPFF) receptors
    Publication number: 20030139431
    Abstract: This invention provides compounds having the structure: 1
    Type: Application
    Filed: September 21, 2002
    Publication date: July 24, 2003
    Inventors: Joel K. Kawakami, John Wetzel, Lakmal W. Boteju, Michael J. Konkel, Honghe Wan, Stewart A. Noble
  • Use of GAL3 receptor antagonists for the treatment of depression and/or anxiety and compounds useful in such methods
    Publication number: 20030078271
    Abstract: This invention is directed to pyrimidine and indolone derivatives which are selective antagonists for the GAL3 receptor. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention also provides a pharmaceutical composition made by combining a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention further provides a process for making a pharmaceutical composition comprising combining a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention also provides a method of treating a subject suffering from depression and/or anxiety which comprises administering to the subject an amount of a compound of the invention effective to treat the subject's depression and/or anxiety.
    Type: Application
    Filed: January 31, 2002
    Publication date: April 24, 2003
    Inventors: Thomas P. Blackburn, Michael J. Konkel, Lakmal W. Boteju, Ian Jamie Talisman, John M. Wetzel, Mathivanan Packiarajan, Heidi Chen, Hermo Jimenez