Patents by Inventor Lakshmi Kotra

Lakshmi Kotra has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Treatments for diabetic neuropathy
    Patent number: 11925649
    Abstract: Treatments for therapy of a diabetic symmetrical polyneuropathy a subject in need thereof. The treatments includes administration of compositions comprising: an effective amount of a muscarinic acetylcholine receptor antagonist exemplified by pirenzepine, telenzepine, atropine, or derivatives thereof or salts thereof or analogs thereof or derivatives thereof, and a pharmacologically acceptable carrier. The composition may be injectable or alternatively, may be applied topically or alternatively, may be delivered orally. A suitable topical composition may comprise a lotion, a cream, a gel, or a viscous fluid. The muscarinic acetylcholine receptor antagonist may be a muscarinic acetylcholine receptor antagonist salt or a muscarinic acetylcholine receptor antagonist derivative or a muscarinic acetylcholine receptor antagonist analog.
    Type: Grant
    Filed: October 15, 2018
    Date of Patent: March 12, 2024
    Assignees: University of Manitoba, University Health Network, The Regents of the university of California
    Inventors: Paul Fernyhough, Nigel A. Calcutt, Lakshmi Kotra
  • Therapeutic compositions for diabetic symmetrical polyneuropathy
    Patent number: 10307428
    Abstract: Compositions for therapy of a diabetic symmetrical polyneuropathy a subject in need thereof, the compositions comprising: an effective amount of a muscarinic acetylcholine receptor antagonist exemplified by pirenzepine, telenzepine, atropine, or derivatives thereof or salts thereof or analogs thereof or derivatives thereof, and a pharmacologically acceptable carrier. The composition may be injectable or alternatively, may be applied topically or alternatively, may be delivered orally. A suitable topical composition may comprise a lotion, a cream, a gel, or a viscous fluid. The muscarinic acetylcholine receptor antagonist may be a muscarinic acetylcholine receptor antagonist salt or a muscarinic acetylcholine receptor antagonist derivative or a muscarinic acetylcholine receptor antagonist analog.
    Type: Grant
    Filed: October 24, 2011
    Date of Patent: June 4, 2019
    Assignees: University Health Network, University of Manitoba, The Regents of The University of California
    Inventors: Paul Fernyhough, Nigel A. Calcutt, Lakshmi Kotra
  • TREATMENTS FOR DIABETIC SYMMETRICAL POLYNEUROPATHY
    Publication number: 20190046540
    Abstract: Treatments for therapy of a diabetic symmetrical polyneuropathy a subject in need thereof. The treatments includes administration of compositions comprising: an effective amount of a muscarinic acetylcholine receptor antagonist exemplified by pirenzepine, telenzepine, atropine, or derivatives thereof or salts thereof or analogs thereof or derivatives thereof, and a pharmacologically acceptable carrier. The composition may be injectable or alternatively, may be applied topically or alternatively, may be delivered orally. A suitable topical composition may comprise a lotion, a cream, a gel, or a viscous fluid. The muscarinic acetylcholine receptor antagonist may be a muscarinic acetylcholine receptor antagonist salt or a muscarinic acetylcholine receptor antagonist derivative or a muscarinic acetylcholine receptor antagonist analog.
    Type: Application
    Filed: October 15, 2018
    Publication date: February 14, 2019
    Inventors: Paul Fernyhough, Nigel A. Calcutt, Lakshmi Kotra
  • Inhibitors of peptidyl arginine deiminase (PAD) enzymes and uses thereof
    Patent number: 9908853
    Abstract: The present application relates to imidazolidinecliones, compositions comprising these compounds and their use, in particular for the treatment of diseases, disorders or conditions characterized by or associated with the hypercitrullination of proteins by peptidyl arginine deiminase (PAD) enzymes. In particular, the present application includes compounds of Formula I, and compositions and uses thereof: (I).
    Type: Grant
    Filed: August 1, 2013
    Date of Patent: March 6, 2018
    Assignees: THE HOSPITAL FOR SICK CHILDREN, UNIVERSITY HEALTH NETWORK
    Inventors: Lakshmi Kotra, Mario Moscarello
  • INHIBITORS OF PEPTIDYL ARGININE DEIMINASE (PAD) ENZYMES AND USES THEREOF
    Publication number: 20150252006
    Abstract: The present application relates to imidazolidinecliones, compositions comprising these compounds and their use, in particular for the treatment of diseases, disorders or conditions characterized by or associated with the hypercitrullination of proteins by peptidyl arginine deiminase (PAD) enzymes. In particular, the present application includes compounds of Formula I, and compositions and uses thereof: (I).
    Type: Application
    Filed: August 1, 2013
    Publication date: September 10, 2015
    Applicants: The Hospital For Sick Children, University Health Network
    Inventors: Lakshmi Kotra, Mario Moscarello
  • THERAPEUTIC COMPOSITIONS FOR DIABETIC SYMMETRICAL POLYNEUROPATHY
    Publication number: 20130267506
    Abstract: Compositions for therapy of a diabetic symmetrical polyneuropathy a subject in need thereof, the compositions comprising: an effective amount of a muscarinic acetylcholine receptor antagonist exemplified by pirenzepine, telenzepine, atropine, or derivatives thereof or salts thereof or analogs thereof or derivatives thereof, and a pharmacologically acceptable carrier. The composition may be injectable or alternatively, may be applied topically or alternatively, may be delivered orally. A suitable topical composition may comprise a lotion, a cream, a gel, or a viscous fluid. The muscarinic acetylcholine receptor antagonist may be a muscarinic acetylcholine receptor antagonist salt or a muscarinic acetylcholine receptor antagonist derivative or a muscarinic acetylcholine receptor antagonist analog.
    Type: Application
    Filed: October 24, 2011
    Publication date: October 10, 2013
    Applicant: UNIVERSITY OF MANITOBA
    Inventors: Paul Fernyhough, Nigel A. Calcutt, Lakshmi Kotra
  • Aminoglycosides as antibiotics
    Patent number: 7759482
    Abstract: The present invention provides aminoglycosides and pharmaceutical compositions that include the aminoglycosides. The aminoglycosides are useful to treat or prevent infectious diseases (e.g., bacterial infections) in a mammal (e.g., human).
    Type: Grant
    Filed: May 2, 2007
    Date of Patent: July 20, 2010
    Assignee: Wayne State University
    Inventors: Jalal Haddad, Lakshmi Kotra, Shahriar Mobashery
  • AMINOGLYCOSIDES AS ANTIBIOTICS
    Publication number: 20070203081
    Abstract: The present invention provides aminoglycosides and pharmaceutical compositions that include the aminoglycosides. The aminoglycosides are useful to treat or prevent infectious diseases (e.g., bacterial infections) in a mammal (e.g., human).
    Type: Application
    Filed: May 2, 2007
    Publication date: August 30, 2007
    Inventors: Jalal Haddad, Lakshmi Kotra, Shahriar Mobashery
  • Aminoglycosides as antibiotics
    Patent number: 7220727
    Abstract: The present invention provides aminoglycosides and pharmaceutical compositions that include the aminoglycosides. The aminogylcosides are useful to treat or prevent infectious diseases (e.g., bacterial infections) in a mammal (e.g., human).
    Type: Grant
    Filed: November 1, 2001
    Date of Patent: May 22, 2007
    Assignee: Wayne State University
    Inventors: Jalal Haddad, Lakshmi Kotra, Shahriar Mobashery
  • Aminoglycosides as antibiotics
    Publication number: 20050171035
    Abstract: The present invention provides aminoglycosides and pharmaceutical compositions that include the aminoglycosides. The aminogylcosides are useful to treat or prevent infectious diseases (e.g., bacterial infections) in a mammal (e.g., human).
    Type: Application
    Filed: November 1, 2001
    Publication date: August 4, 2005
    Inventors: Jalal Haddad, Lakshmi Kotra, Shahriar Mobashery