Patents by Inventor Lakshmi Prabha Varadarajalu

Lakshmi Prabha Varadarajalu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of producing biologically active polypeptide having insulinotropic activity
    Patent number: 8114632
    Abstract: The present invention relates to a method of producing a biologically active polypeptide having insulinotropic activity, the method comprising steps of: (a) transforming a genetically modified host cell that has protease gene knockout, with a polynucleotide vector encoding the polypeptide; and (b) growing the transformed host cell to produce the biologically active polypeptide; and a method of producing a biologically active polypeptide having an N-terminal recognition site His-Gly with insulinotropic activity, the method comprising steps of: (a) transforming a genetically modified Pichia pastoris that has protease gene STE13 knockout, with a polynucleotide vector encoding the polypeptide; and (b) growing the transformed Pichia pastoris to produce the biologically active polypeptide.
    Type: Grant
    Filed: June 20, 2007
    Date of Patent: February 14, 2012
    Assignee: Biocon Limited
    Inventors: Ramakrishnan Melarkode, Akundi Venkata Sriram, Kedarnath Nanjund Sastry, Lakshmi Prabha Varadarajalu, Shrikumar Suryanarayan
  • METHOD OF PRODUCING BIOLOGICALLY ACTIVE POLYPEPTIDE HAVING INSULINOTROPIC ACTIVITY
    Publication number: 20100167342
    Abstract: The present invention relates to a method of producing a biologically active polypeptide having insulinotropic activity, the method comprising steps of: (a) transforming a genetically modified host cell that has protease gene knockout, with a polynucleotide vector encoding the polypeptide; and (b) growing the transformed host cell to produce the biologically active polypeptide; and a method of producing a biologically active polypeptide having an N-terminal recognition site His-Gly with insulinotropic activity, the method comprising steps of: (a) transforming a genetically modified Pichia pastoris that has protease gene STE13 knockout, with a polynucleotide vector encoding the polypeptide; and (b) growing the transformed Pichia pastoris to produce the biologically active polypeptide.
    Type: Application
    Filed: June 20, 2007
    Publication date: July 1, 2010
    Applicant: BIOCON LIMITED,
    Inventors: Ramakrishnan Melarkode, Akundi Venkata Sriram, Kedarnath Nanjund Sastry, Lakshmi Prabha Varadarajalu, Shrikumar Suryanarayan