Patents by Inventor Lakshmi Sangameswaran

Lakshmi Sangameswaran has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210409445
    Abstract: Obtaining one or more metrics associated with a network location. Determining, based on the one or more metrics and one or more prefatory check conditions, a prefatory status of the network location, the prefatory status indicating a benign status, malicious status, or a suspicious status. If the prefatory status of the network location indicates the benign status or the malicious status, providing a notification of the prefatory status in response to the prefatory status being determined. If the prefatory status of the network location indicates a suspicious status, obtaining a document object model of the network location. Obtaining a screenshot of an entire page of content at the network location. Generating a null hypothesis based on the document object model, the null hypothesis including a potential brand list, the potential brand list including one or more potential brands. Obtaining a set of reference images for each of the one or more potential brands of the potential brand list.
    Type: Application
    Filed: June 25, 2021
    Publication date: December 30, 2021
    Applicant: Zoho Corporation Private Limited
    Inventors: Gouttham Nambirajan, Sita Lakshmi Sangameswaran, Ramprakash Ramamoorthy, Shailesh Kumar Davey
  • Patent number: 8158682
    Abstract: This present invention relates to methods for treating or attenuating pain in a patient. Specifically, the invention provides a method for attenuating pain in proximity to the site of an open wound or surgical incision comprising instilling a pharmaceutical composition comprising a capsaicinoid into the wound or incision, allowing the pharmaceutical composition to dwell for a predetermined period of time, and aspirating the wound or incision to remove the pharmaceutical composition. The invention also provides a method for attenuating pain in proximity to a joint comprising intra-articularly injecting a pharmaceutical composition comprising a capsaicinoid into the joint, allowing the pharmaceutical composition to dwell for predetermined period of time, and aspirating the joint to remove the pharmaceutical composition. In certain embodiments of the invention, the capsaicinoid is capsaicin.
    Type: Grant
    Filed: September 14, 2009
    Date of Patent: April 17, 2012
    Assignee: Vallinex, Inc.
    Inventors: Lakshmi Sangameswaran, Susan Kramer
  • Publication number: 20100234470
    Abstract: This present invention relates to methods for treating or attenuating pain in a patient. Specifically, the invention provides a method for attenuating pain in proximity to the site of an open wound or surgical incision comprising instilling a pharmaceutical composition comprising a capsaicinoid into the wound or incision, allowing the pharmaceutical composition to dwell for a predetermined period of time, and aspirating the wound or incision to remove the pharmaceutical composition. The invention also provides a method for attenuating pain in proximity to a joint comprising intra-articularly injecting a pharmaceutical composition comprising a capsaicinoid into the joint, allowing the pharmaceutical composition to dwell for predetermined period of time, and aspirating the joint to remove the pharmaceutical composition. In certain embodiments of the invention, the capsaicinoid is capsaicin.
    Type: Application
    Filed: September 14, 2009
    Publication date: September 16, 2010
    Applicant: ANESIVA, INC.
    Inventors: Lakshmi Sangameswaran, Susan Kramer
  • Patent number: 7122325
    Abstract: The present invention relates to a voltage-gated sodium channel present in peripheral nerve tissue that is tetrodotoxin-resistant. One aspect of the present invention is purified and isolated DNA encoding this sodium channel. Another aspect of the present invention is the recombinant protein expressed by this DNA, expression vectors comprising the DNA sequence, and host cells transformed with these expression vectors. Another aspect of this invention is the use of this voltage-gated, tetrodotoxin-resistant sodium channel as a therapeutic target for compounds to treat disorders of the peripheral nervous system.
    Type: Grant
    Filed: August 1, 2002
    Date of Patent: October 17, 2006
    Assignee: Syntex (U.S.A.) LLC
    Inventors: Ronald Herman, Stephen Gregory Delgado, Linda Marie Fish, Lakshmi Sangameswaran, Douglas Kenneth Rabert
  • Publication number: 20060009432
    Abstract: Ganaxolone (3?-hydroxy-3?-methyl-5?-pregnan-20-one) and 3?-hydroxy-3?-methyl-5?-pregnan-20-one and their physiologically cleavable esters are useful for treating neuropathic pain. Compositions comprising a pharmaceutically acceptable excipient and an appropriate compound, along with methods for preparing the compositions are disclosed. Also disclosed are articles of manufacture wherein the composition is combine with labeling instructions for treating neuropathic pain.
    Type: Application
    Filed: July 8, 2005
    Publication date: January 12, 2006
    Inventors: Roger Whiting, Lakshmi Sangameswaran
  • Publication number: 20050186627
    Abstract: The present invention relates to a voltage-gated sodium channel present in peripheral nerve tissue that is tetrodotoxin-resistant. One aspect of the present invention is purified and isolated DNA encoding this sodium channel. Another aspect of the present invention is the recombinant protein expressed by this DNA, expression vectors comprising the DNA sequence, and host cells transformed with these expression vectors. Another aspect of this invention is the use of this voltage-gated, tetrodotoxin-resistant sodium channel as a therapeutic target for compounds to treat disorders of the peripheral nervous system.
    Type: Application
    Filed: April 14, 2005
    Publication date: August 25, 2005
    Inventors: Ronald Herman, Stephen Delgado, Linda Fish, Lakshmi Sangameswaran, Douglas Rabert
  • Publication number: 20030196212
    Abstract: The present invention relates to mammalian receptors, particularly novel pheromone receptors and the expression of these receptors in selected cells and tissues. More specifically, the invention encompasses a novel human pheromone receptor. The invention contemplates nucleic acid molecules and fragment(s) thereof encoding a human pheromone receptor, and agents that specifically bind to the polypeptides comprising the human pheromone receptor. The invention also encompasses vectors and cells for producing the nucleic acid molecules encoding the human pheromone receptor as well as vectors and cells for expressing receptor polypeptides. The invention further relates to methods for isolation, characterization and detection of the nucleic acid molecules, polypeptides, and agents that bind to the receptor. The invention also encompasses diagnosis and treatment of diseases or disorders related to the aberrant expression of the human pheromone receptor.
    Type: Application
    Filed: April 10, 2002
    Publication date: October 16, 2003
    Inventors: Jian Zhang, Ronald C. Herman, Lakshmi Sangameswaran, David C. Edwards, Ganapathirama Raghu
  • Publication number: 20030143541
    Abstract: The present invention relates to mammalian receptors, particularly human pheromone receptors and the expression of these receptors in selected cells and tissues. More specifically, the invention encompasses novel human vomeronasal organ (VNO) receptors. The invention contemplates nucleic acid molecules and fragments thereof encoding human pheromone receptors and agents that specifically bind to the polypeptides comprising human pheromone receptors. The invention also encompasses vectors and cells for producing the nucleic acid molecules encoding human pheromone receptors as well as vectors and cells for expressing receptor polypeptides. The invention further relates to methods for isolation, characterization and detection of the nucleic acid molecules, polypeptides, and agents that bind to the receptors. The invention also encompasses diagnosis and treatment of diseases or disorders related to the aberrant expression of the human pheromone receptors hV3R1 and hV3R8.
    Type: Application
    Filed: December 27, 2001
    Publication date: July 31, 2003
    Inventor: Lakshmi Sangameswaran
  • Publication number: 20030096360
    Abstract: The present invention relates to a voltage-gated sodium channel present in peripheral nerve tissue that is tetrodotoxin-resistant. One aspect of the present invention is purified and isolated DNA encoding this sodium channel. Another aspect of the present invention is the recombinant protein expressed by this DNA, expression vectors comprising the DNA sequence, and host cells transformed with these expression vectors. Another aspect of this invention is the use of this voltage-gated, tetrodotoxin-resistant sodium channel as a therapeutic target for compounds to treat disorders of the peripheral nervous system.
    Type: Application
    Filed: August 1, 2002
    Publication date: May 22, 2003
    Inventors: Ronald Herman, Stephen Gregory Delgado, Linda Marie Fish, Lakshmi Sangameswaran, Douglas Kenneth Rabert
  • Publication number: 20030003538
    Abstract: The invention provides NPGs from rat and human, reagents related thereto including polynucleotides encoding NPGs, purified polypeptides, and specific antibodies. Methods of making and using these reagents, in particular, methods for screening compounds which modulate NPGs activity are provided. Also provided are methods of diagnosis, kits, and transgenic animals.
    Type: Application
    Filed: May 15, 2002
    Publication date: January 2, 2003
    Inventors: Paul Shartzer Dietrich, Chiao-Chain Huang, Carl D. Johnson, Lakshmi Sangameswaran
  • Patent number: 6479259
    Abstract: The present invention relates to a voltage-gated sodium channel present in peripheral nerve tissue that is tetrodotoxin-resistant. One aspect of the present invention is purified and isolated DNA encoding this sodium channel. Another aspect of the present invention is the recombinant protein expressed by this DNA, expression vectors comprising the DNA sequence, and host cells transformed with these expression vectors. Another aspect of this invention is the use of this voltage-gated, tetrodotoxin-resistant sodium channel as a therapeutic target for compounds to treat disorders of the peripheral nervous system.
    Type: Grant
    Filed: March 16, 2000
    Date of Patent: November 12, 2002
    Assignee: Syntex (U.S.A.) LLC
    Inventors: Ronald Herman, Stephen Gregory Delgado, Linda Marie Fish, Lakshmi Sangameswaran, Douglas Kenneth Rabert
  • Patent number: 6335172
    Abstract: DNA encoding for a voltage-gated, TTX-sensitive sodium channel is isolated. Also disclosed are polypeptide products of recombinant expression of these DNA sequences, expression vectors comprising the DNA sequences, and host cells transformed with these expression vectors. Other aspects of this invention are peptides whose sequences are based on the amino acid sequences deduced from these DNA sequences, antibodies specific for such proteins and peptides, procedures for detection and quantitation of such proteins, and nucleic acids related thereto. Another aspect of this invention is the use of this voltage-gated, tetrodotoxin-sensitive sodium channel as a therapeutic target for compounds.
    Type: Grant
    Filed: October 21, 1999
    Date of Patent: January 1, 2002
    Assignee: Syntex (U.S.A.) LLC
    Inventors: Stephen Gregory Delgado, Paul Shartzer Dietrich, Linda Marie Fish, Ronald Charles Herman, Lakshmi Sangameswaran
  • Patent number: 6184349
    Abstract: The present invention relates to a voltage-gated sodium channel present in peripheral nerve tissue that is tetrodotoxin-resistant. One aspect of the present invention is purified and isolated DNA encoding this sodium channel. Another aspect of the present invention is the recombinant protein expressed by this DNA, expression vectors comprising the DNA sequence, and host cells transformed with these expression vectors. Another aspect of this invention is the use of this voltage-gated, tetrodotoxin-resistant sodium channel as a therapeutic target for compounds to treat disorders of the peripheral nervous system.
    Type: Grant
    Filed: April 15, 1997
    Date of Patent: February 6, 2001
    Assignee: Syntex (USA) Inc.
    Inventors: Ronald Herman, Stephen Gregory Delgado, Linda Marie Fish, Lakshmi Sangameswaran, Douglas Kenneth Rabert
  • Patent number: 6030810
    Abstract: DNA encoding for a voltage-gated, TTX-sensitive sodium channel is isolated. Also disclosed are polypeptide products of recombinant expression of these DNA sequences, expression vectors comprising the DNA sequences, and host cells transformed with these expression vectors. Other aspects of this invention are peptides whose sequences are based on the amino acid sequences deduced from these DNA sequences, antibodies specific for such proteins and peptides, procedures for detection and quantitation of such proteins, and nucleic acids related thereto. Another aspect of this invention is the use of this voltage-gated, tetrodotoxin-sensitive sodium channel as a therapeutic target for compounds.
    Type: Grant
    Filed: February 16, 1998
    Date of Patent: February 29, 2000
    Inventors: Stephen Gregory Delgado, Paul Shartzer Dietrich, Linda Marie Fish, Ronald Charles Herman, Lakshmi Sangameswaran