Patents by Inventor Lakshmi Sastry-Dent

Lakshmi Sastry-Dent has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • OPTIMAL MAIZE LOCI
    Publication number: 20220162624
    Abstract: As disclosed herein, optimal native genomic loci from maize plants have been identified that represent best sites for targeted insertion of exogenous sequences.
    Type: Application
    Filed: October 13, 2021
    Publication date: May 26, 2022
    Applicant: CORTEVA AGRISCIENCE LLC
    Inventors: Lakshmi SASTRY-DENT, Zehui CAO, Shreedharan SRIRAM, Steven R. WEBB, Debra L. CAMPER
  • Optimal maize loci
    Patent number: 11198882
    Abstract: As disclosed herein, optimal native genomic loci from maize plants have been identified that represent best sites for targeted insertion of exogenous sequences.
    Type: Grant
    Filed: August 24, 2018
    Date of Patent: December 14, 2021
    Inventors: Lakshmi Sastry-Dent, Zehui Cao, Shreedharan Sriram, Steven R. Webb, Debra L. Camper
  • Optimal soybean loci
    Patent number: 11149287
    Abstract: As disclosed herein, optimal native genomic loci have been identified in dicot plants, such as soybean plants, that represent best sites for targeted insertion of exogenous sequences.
    Type: Grant
    Filed: January 14, 2019
    Date of Patent: October 19, 2021
    Assignee: Corteva Agriscience LLC
    Inventors: Lakshmi Sastry-Dent, Zehui Cao, Shreedharan Sriram, Steven R. Webb, Debra L. Camper
  • Optimal soybean loci
    Patent number: 11098316
    Abstract: As disclosed herein, optimal native genomic loci of soybean plants have been identified that represent best sites for targeted insertion of exogenous sequences.
    Type: Grant
    Filed: September 6, 2018
    Date of Patent: August 24, 2021
    Assignee: Corteva Agriscience LLC
    Inventors: Lakshmi Sastry-Dent, Zehui Cao, Shreedharan Sriram, Steven R. Webb, Debra L. Camper, W. Michael Ainley
  • Optimal maize loci
    Patent number: 11098317
    Abstract: As disclosed herein, optimal native genomic loci have been identified in monocot plants, such as maize plants, that represent best sites for targeted insertion of exogenous sequences.
    Type: Grant
    Filed: January 31, 2019
    Date of Patent: August 24, 2021
    Assignee: Corteva Agriscience LLC
    Inventors: Lakshmi Sastry-Dent, Zehui Cao, Shreedharan Sriram, Steven R. Webb, Debra L. Camper, Navin Elango
  • Targeted modification of malate dehydrogenase
    Patent number: 11085092
    Abstract: Disclosed herein are methods and compositions for targeted modification of one or more endogenous plant malate dehydrogenase genes.
    Type: Grant
    Filed: July 2, 2019
    Date of Patent: August 10, 2021
    Assignees: Corteva Agriscience LLC, Sangamo Therapeutics, Inc.
    Inventors: Vipula Shukla, Manju Gupta, Fyodor Urnov, Dmitry Y. Guschin, Michiel Jan De Both, Paul Bundock, Lakshmi Sastry-Dent
  • OPTIMAL SOYBEAN LOCI
    Publication number: 20210230617
    Abstract: As disclosed herein, optimal native genomic loci of soybean plants have been identified that represent best sites for targeted insertion of exogenous sequences.
    Type: Application
    Filed: April 7, 2021
    Publication date: July 29, 2021
    Inventors: Lakshmi SASTRY-DENT, Zehui CAO, Shreedharan SRIRAM, Steven R. WEBB, Debra L. CAMPER, W. Michael AINLEY
  • METHODS AND SYSTEMS FOR PREDICTING THE RISK OF TRANSGENE SILENCING
    Publication number: 20200224269
    Abstract: The present invention is based on the use of the H3K9me2 methylation levels in plant genomes to predict transgene silencing, transgene stability, and/or transgene expression level. Provided are methods and/or systems for generating whole-genome H3K9me2 maps and its use with an assigned threshold value for predicting gene silencing. The methods and/or systems provided herein can be used in high-throughput setting for screening large number of transformed event in a relatively short period of time as compared to existing technologies.
    Type: Application
    Filed: March 16, 2020
    Publication date: July 16, 2020
    Applicant: Dow AgroSciences LLC
    Inventors: PoHao Wang, Shreedharan Sriram, Lakshmi Sastry-Dent
  • Methods and systems for predicting the risk of transgene silencing
    Patent number: 10633703
    Abstract: The present invention is based on the use of the H3K9me2 methylation levels in plant genomes to predict transgene silencing, transgene stability, and/or transgene expression level. Provided are methods and/or systems for generating whole-genome H3K9me2 maps and its use with an assigned threshold value for predicting gene silencing. The methods and/or systems provided herein can be used in high-throughput setting for screening large number of transformed event in a relatively short period of time as compared to existing technologies.
    Type: Grant
    Filed: October 25, 2016
    Date of Patent: April 28, 2020
    Assignee: Dow AgroSciences LLC
    Inventors: Pohao Wang, Shreedharan Sriram, Lakshmi Sastry-Dent
  • TARGETED MODIFICATION OF MALATE DEHYDROGENASE
    Publication number: 20190327928
    Abstract: Disclosed herein are methods and compositions for targeted modification of one or more endogenous plant malate dehydrogenase genes.
    Type: Application
    Filed: July 2, 2019
    Publication date: October 31, 2019
    Inventors: Vipula Shukla, Manju Gupta, Fyodor Urnov, Dmitry Y. Guschin, Michiel Jan De Both, Paul Bundock, Lakshmi Sastry-Dent
  • Precision gene targeting to a particular locus in maize
    Patent number: 10415046
    Abstract: The present invention claims methods for the stable integration of exogenous DNA into a specific locus, E32, in the maize genome through the use of zinc finger nucleases. Maize plants and plant parts that were transformed by the methods of the invention are claimed. The invention is useful for creating desirable traits such as herbicide resistance, herbicide tolerance, insect resistance, insect tolerance, disease resistance, disease tolerance, stress tolerance, and stress resistance in maize The E32 locus represents a superior site for inserting foreign genes because native agronomic phenotypes are not disturbed.
    Type: Grant
    Filed: October 31, 2016
    Date of Patent: September 17, 2019
    Assignee: Dow AgroSciences LLC
    Inventors: W. Michael Ainley, James W. Bing, David R. Corbin, Steven L. Evans, Joseph F. Petolino, Lakshmi Sastry-Dent, Steven A. Thompson, Steven R. Webb, Mary E. Welter, Ning Zhou
  • Targeted modification of malate dehydrogenase
    Patent number: 10358684
    Abstract: Disclosed herein are methods and compositions for targeted modification of one or more endogenous plant malate dehydrogenase genes.
    Type: Grant
    Filed: December 14, 2016
    Date of Patent: July 23, 2019
    Assignees: Dow AgroSciences LLC, Sangamo Therapeutics, Inc.
    Inventors: Vipula Shukla, Manju Gupta, Fyodor Urnov, Dmitry Y. Guschin, Michiel Jan De Both, Paul Bundock, Lakshmi Sastry-Dent
  • DNA detection methods for site specific nuclease activity
    Patent number: 10344322
    Abstract: The present disclosure provides methods for detecting and identifying plant events that contain precision targeted genomic loci, and plants and plant cells comprising such targeted genomic loci. The method can be deployed as a high throughput process utilized for screening the intactness or disruption of a targeted genomic loci and optionally for detecting a donor DNA polynucleotide insertion at the targeted genomic loci. The methods are readily applicable for the identification of plant events produced via a targeting method which results from the use of a site specific nuclease.
    Type: Grant
    Filed: August 29, 2016
    Date of Patent: July 9, 2019
    Assignee: Dow AgroSciences LLC
    Inventors: Lakshmi Sastry-Dent, Matthew A. Simpson, Zehui Cao, Wei Chen, Ning Zhou, Steven R. Webb
  • OPTIMAL MAIZE LOCI
    Publication number: 20190194674
    Abstract: As disclosed herein, optimal native genomic loci have been identified in monocot plants, such as maize plants, that represent best sites for targeted insertion of exogenous sequences.
    Type: Application
    Filed: January 31, 2019
    Publication date: June 27, 2019
    Inventors: Lakshmi SASTRY-DENT, Zehui CAO, Shreedharan SRIRAM, Steven R. WEBB, Debra L. CAMPER, Navin ELANGO
  • OPTIMAL SOYBEAN LOCI
    Publication number: 20190136265
    Abstract: As disclosed herein, optimal native genomic loci have been identified in dicot plants, such as soybean plants, that represent best sites for targeted insertion of exogenous sequences.
    Type: Application
    Filed: January 14, 2019
    Publication date: May 9, 2019
    Inventors: Lakshmi SASTRY-DENT, Zehui CAO, Shreedharan SRIRAM, Steven R. WEBB, Debra L. CAMPER
  • Optimal maize loci
    Patent number: 10273493
    Abstract: As disclosed herein, optimal native genomic loci have been identified in monocot plants, such as maize plants, that represent best sites for targeted insertion of exogenous sequences.
    Type: Grant
    Filed: November 3, 2014
    Date of Patent: April 30, 2019
    Assignee: Dow AgroSciences LLC
    Inventors: Lakshmi Sastry-Dent, Zehui Cao, Shreedharan Sriram, Steven R. Webb, Debra L. Camper, Navin Elango
  • Optimal soybean loci
    Patent number: 10233465
    Abstract: As disclosed herein, optimal native genomic loci have been identified in dicot plants, such as soybean plants, that represent best sites for targeted insertion of exogenous sequences.
    Type: Grant
    Filed: November 3, 2014
    Date of Patent: March 19, 2019
    Assignee: Dow AgroSciences LLC
    Inventors: Lakshmi Sastry-Dent, Zehui Cao, Shreedharan Sriram, Steven R. Webb, Debra L. Camper
  • OPTIMAL MAIZE LOCI
    Publication number: 20190024100
    Abstract: As disclosed herein, optimal native genomic loci from maize plants have been identified that represent best sites for targeted insertion of exogenous sequences.
    Type: Application
    Filed: August 24, 2018
    Publication date: January 24, 2019
    Inventors: Lakshmi Sastry-Dent, Zehui Cao, Shreedharan Sriram, Steven R. Webb, Debra L. Camper
  • Methods and compositions for nuclease-mediated targeted integration of transgenes
    Patent number: 10174331
    Abstract: Disclosed herein are methods and compositions for homology-independent targeted insertion of donor molecules into the genome of a cell.
    Type: Grant
    Filed: May 7, 2013
    Date of Patent: January 8, 2019
    Assignees: Sangamo Therapeutics, Inc., Dow AgroSciences LLC
    Inventors: Gregory J. Cost, Fyodor Urnov, W. Michael Ainley, Joseph F. Petolino, Jayakumar Pon Samuel, Steven R. Webb, Lakshmi Sastry-Dent
  • OPTIMAL SOYBEAN LOCI
    Publication number: 20180371478
    Abstract: As disclosed herein, optimal native genomic loci of soybean plants have been identified that represent best sites for targeted insertion of exogenous sequences.
    Type: Application
    Filed: September 6, 2018
    Publication date: December 27, 2018
    Inventors: Lakshmi Sastry-Dent, Zehui Cao, Shreedharan Sriram, Steven R. Webb, Debra L. Camper, W. Michael Ainley