Abstract: An electroporation system is provided. The electroporation system includes a catheter including at least one therapeutic electrode, a plurality of return electrodes, a pulse generator configured to apply energy between the at least one therapeutic electrode and the plurality of return electrodes to generate a lesion at the at least one therapeutic electrode, and at least one impedance load, each of the at least one impedance load coupled between the pulse generator and one of the plurality of return electrodes.

Abstract: An electroporation system is provided. The electroporation system includes a catheter comprising a plurality of electrodes, and a pulse generator coupled to the catheter, the pulse generator configured to generate a waveform to be delivered using at least one of the plurality of electrodes. The waveform includes a plurality of bursts, each burst including a plurality of loops, and each loop including a plurality of pulses, wherein each of the plurality of pulses has a pulse width of 3 microseconds (?s) or less, wherein each burst includes no more than ten loops, wherein the plurality of bursts include at least ten bursts, and wherein the pulse widths, number of loops per burst, and number of bursts facilitate reducing microbubble formation.

Abstract: Systems and methods for electroporation are provided. An electroporation system includes a catheter including a plurality of electrodes, and a pulse generator coupled to the catheter, the pulse generator configured to generate a waveform to be delivered using at least one of the plurality of electrodes. The waveform includes a first pulse having a first polarity, a first pulse amplitude, and a first pulse width, and a second pulse having a second polarity, a second pulse amplitude, and a second pulse width, wherein the first and second pulses are separated by an interpulse delay, and wherein at least one of i) the first pulse amplitude is different than the second pulse amplitude and ii) the first pulse width is different than the second pulse width.