Patents by Inventor Lalitha Iyer

Lalitha Iyer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for detection of promoter polymorphism in a UGT gene promoter
    Publication number: 20090318487
    Abstract: The present invention is directed to methods for detecting the presence of genetic polymorphisms that correlate with altered gene expression. More specifically, the present invention is directed to methods for detecting the genetic polymorphisms located in the UGT1A1 promoter. The invention also provides methods for optimizing drug dosages based upon the presence of the polymorphisms. The invention further provides methods of predicting sensitivity to xenobiotics and diagnostic kits for detecting genetic polymorphisms.
    Type: Application
    Filed: July 27, 2009
    Publication date: December 24, 2009
    Inventors: Anna Di Rienzo, Lalitha Iyer, Mark J. Ratain
  • Methods for Detection of Promoter Polymorphism in UGT Gene Promoter
    Publication number: 20070092902
    Abstract: The present invention is directed to methods for detecting the presence of genetic polymorphisms that correlate with altered gene expression. More specifically, the present invention is directed to methods for detecting the genetic polymorphisms located in the UGT1A1 promoter. The invention also provides methods for optimizing drug dosages based upon the presence of the polymorphisms. The invention further provides methods of predicting sensitivity to xenobiotics and diagnostic kits for detecting genetic polymorphisms.
    Type: Application
    Filed: November 17, 2006
    Publication date: April 26, 2007
    Inventors: Anna Di Rienzo, Lalitha Iyer, Mark Ratain
  • Methods for detection of promoter polymorphism in a UGT gene promoter
    Publication number: 20060147907
    Abstract: The present invention is directed to methods for detecting the presence of genetic polymorphisms that correlate with altered gene expression. More specifically, the present invention is directed to methods for detecting the genetic polymorphisms located in the UGT1A1 promoter. The invention also provides methods for optimizing drug dosages based upon the presence of the polymorphisms. The invention further provides methods of predicting sensitivity to xenobiotics and diagnostic kits for detecting genetic polymorphisms.
    Type: Application
    Filed: October 21, 2002
    Publication date: July 6, 2006
    Inventors: Anna Rienzo, Lalitha Iyer, Mark Ratain
  • Methods for detection of promoter polymorphism in a UGT gene promoter
    Publication number: 20030152968
    Abstract: The present invention is directed to methods for detecting the presence of genetic polymorphisms that correlate with altered gene expression. More specifically, the present invention is directed to methods for detecting the genetic polymorphisms located in the UGT1A1 promoter. The invention also provides methods for optimizing drug dosages based upon the presence of the polymorphisms. The invention further provides methods of predicting sensitivity to xenobiotics and diagnostic kits for detecting genetic polymorphisms.
    Type: Application
    Filed: October 21, 2002
    Publication date: August 14, 2003
    Applicant: Arch Development Corporation
    Inventors: Anna Di Rienzo, Lalitha Iyer, Mark J. Ratain
  • Compositions and methods for optimizing UGT2B7 substrate dosings and for predicting UGT2B7 substrate toxicity
    Publication number: 20030099960
    Abstract: This invention concerns UGT2B7 and its ability to glucuronidate various drugs, including epirubicin. It concerns methods and compositions for determining the level of UGT2B7 activity based on genetic composition, and consequently, allows dosing of UTG2B7-glucuronidated drugs to be improved or optimized based on a patient's level of predicted UGT2B7 activity. It further concerns methods of treatment in which UGT2B7 substrates are administered to patients as part of a treatment regimen.
    Type: Application
    Filed: January 25, 2002
    Publication date: May 29, 2003
    Applicant: The University of Chicago
    Inventors: Mark J. Ratain, Federico Innocenti, Soma Das, Lalitha Iyer, Michael Sawyer
  • Methods for detection of promoter polymorphism in a UGT gene promoter
    Patent number: 6472157
    Abstract: The present invention is directed to methods for detecting the presence of genetic polymorphisms that correlate with altered gene expression. More specifically, the present invention is directed to methods for detecting the genetic polymorphisms located in the UGT1A1 promoter. The invention also provides methods for optimizing drug dosages based upon the presence of the polymorphisms. The invention further provides methods of predicting sensitivity to xenobiotics and diagnostic kits for detecting genetic polymorphisms.
    Type: Grant
    Filed: February 1, 2002
    Date of Patent: October 29, 2002
    Assignee: Arch Development Corporation
    Inventors: Anna Di Rienzo, Lalitha Iyer, Mark J. Ratain
  • Methods for detection of promoter polymorphism in a UGT gene promoter
    Publication number: 20020115097
    Abstract: The present invention is directed to methods for detecting the presence of genetic polymorphisms that correlate with altered gene expression. More specifically, the present invention is directed to methods for detecting the genetic polymorphisms located in the UGT1A1 promoter. The invention also provides methods for optimizing drug dosages based upon the presence of the polymorphisms. The invention further provides methods of predicting sensitivity to xenobiotics and diagnostic kits for detecting genetic polymorphisms.
    Type: Application
    Filed: February 1, 2002
    Publication date: August 22, 2002
    Applicant: Arch Development Corporation
    Inventors: Anna Di Rienzo, Lalitha Iyer, Mark J. Ratain
  • Methods for detection of promoter polymorphism in a UGT gene promoter
    Patent number: 6395481
    Abstract: The present invention is, directed to methods for detecting the presence of genetic polymorphisms that correlate with altered gene expression. More specifically, the present invention is directed to methods for detecting the genetic polymorphisms located in the UGT1A1 promoter. The invention also provides methods for optimizing drug dosages based upon the presence of the polymorphisms. The invention further provides methods of predicting sensitivity to xenobiotics and diagnostic kits for detecting genetic polymorphisms.
    Type: Grant
    Filed: February 16, 1999
    Date of Patent: May 28, 2002
    Assignee: Arch Development Corp.
    Inventors: Anna Di Rienzo, Lalitha Iyer, Mark J. Ratain
  • Flavopiridol drug combinations and methods with reduced side effects
    Publication number: 20020016293
    Abstract: This invention provides methods, formulations and kits to reduce the toxicity of flavopiridol and analogs thereof. Disclosed are therapeutics and treatment methods employing such drugs in combination with agents that increase conjugative enzyme activity or glucuronosyltransferase activity, and agents that decrease biliary transport protein activity, such as cyclosporine A, the resultant effects of which are to decrease the significant side effects previously associated with treatment using these drugs. The invention also characterizes specific isoforms of glucuronyltransferase enzymes involved in glucuronidation of flavopiridols and their analogs.
    Type: Application
    Filed: April 12, 2001
    Publication date: February 7, 2002
    Inventors: Mark J. Ratain, Federico Innocenti, Lalitha Iyer