Abstract: Embodiments generally relate to a system for managing media resources from a plurality of mobile devices and delivered by a vehicle. In particular, embodiments relate to an apparatus for providing a queue of media resources from a mobile device to a vehicle. The apparatus comprises a wireless transceiver, a vehicle interface, and a processor. The processor establishes a wireless connection to the mobile device and then receives a uniform resource identifier (URI) for a media resource from the mobile device. It then processes the URI to determine information on the media resource, including its media type and selects a media source associated with the media type that comprises the media resource. The processor next adds the media resource to the queue of media resources, which is broadcast via the wireless connection, and triggers the media source to provide the media resource to the vehicle via the vehicle interface.

Abstract: Provided are various embodiments relating to variant IgG Fc polypeptides of companion animals having increased Protein A binding for ease of purification, decreased C1q binding for reduced complement-mediated immune responses, decreased CD16 binding (e.g., for reduced antibody-dependent cellular cytotoxicity (ADCC) induction), increased stability, and/or the ability to form multimeric proteins. In addition, various embodiments relating to antibodies and fusion proteins comprising such variant IgG Fc polypeptides are provided. In various embodiments, such polypeptides may be used to treat companion animals, such as canines, felines, and equines.

Abstract: Provided are various embodiments relating to variant asparaginase polypeptides with enhanced stability, pharmacodynamics, and/or reduced immunogenicity. The variant asparaginase polypeptides may be used as therapeutics in mammals, including human, canines, felines, and equines.

Abstract: Embodiments are provided for unsupervised learning of domain specific knowledge graph from textual data and language generation from knowledge graph via reinforcement learning in a computing system by a processor. Unstructured data is automatically parsed into one or more knowledge graphs based on the unstructured data and a list of candidate relations using a first machine learning model. Text data is generated from the one or more knowledge graphs using a second machine learning model.

Abstract: An article of manufacture comprises: a first integrated circuit, with a cavity formed through an entire thickness between a first surface of the first integrated circuit and a second surface of the first integrated circuit; a second integrated circuit having a size such that at least a portion of the second integrated circuit fits within at least a portion of the cavity; and a thermally conductive structure mechanically connected to the second surface of the first integrated circuit and mechanically connected to a surface of the second integrated circuit. A feature of the first integrated circuit and a feature of the second integrated circuit are positioned at respective distances from a reference plane intersecting a portion of the thermally conductive structure, such that the distances remain substantially equal to each other at each of a plurality of temperatures within a predetermined operating temperature range.

Abstract: Provided are various embodiments relating to IL13R/IL4R contiguous polypeptides derived from companion animal species and that bind to IL13 and/or IL4. Such contiguous polypeptides can be used in methods to treat IL13 and/or IL4-induced conditions in companion animals, such as canines, felines, and equines.

Abstract: Provided are various embodiments relating to IL13R/IL4R contiguous polypeptides and IL13R/IL4R heterodimeric proteins from companion animal species and that bind to IL13 and/or IL4, including long-acting contiguous polypeptides and heterodimeric proteins. Such heterodimeric proteins can be used in methods to treat IL13 and/or IL4-induced conditions in companion animals, such as canines, felines, and equines.

Abstract: Provided are various embodiments relating to interleukin 13 receptor subunit alpha-1/interleukin 4 receptor subunit alpha (IL13R/IL4R) contiguous polypeptides derived from companion animal species and that bind to IL13 and/or IL4. Such contiguous polypeptides can be used in methods to treat IL13 and/or IL4-induced conditions in companion animals, such as canines, felines, and equines.

Abstract: In an approach for compressing a neural network, a processor receives a neural network, wherein the neural network has been trained on a set of training data. A processor receives a compression ratio. A processor compresses the neural network based on the compression ratio using an optimization model to solve for sparse weights. A processor re-trains the compressed neural network with the sparse weights. A processor outputs the re-trained neural network.

Abstract: A system includes a fluid spray gun comprising a spray tip having a tip orifice, a pump configured to pump fluid along a flow path to the fluid spray gun, and a monitoring system comprising one or more processors. The monitoring system is configured to obtain data indicative of a flow rate of the fluid along the flow path, obtain data indicative of a pressure of the fluid along the flow path, and determine a tip wear metric indicative of a wear of the spray tip based, at least, on the data indicative of the flow rate of the fluid along the flow path and the data indicative of the pressure of the fluid along the flow path. The monitoring system further controls a display screen to generate a display based on the tip wear metric.

Abstract: The present disclosure concerns hyperthermic devices for treating vascular involvements related to cancer therapies, such as surgery. In specific embodiments, the device is configured to provide therapeutic heating to destroy vessel-encasing tumors while still protecting the vessel itself. In particular embodiments, the devices utilize two opposing semi-cylindrical shells that encase the vessel in need of treatment of a tumor thereon. In other devices, a flexible substrate is guided under and around the vessel and tumor thereon.

Abstract: A system and methods of isolating probiotics and adding probiotics into matrices are disclosed, comprising: (a) selecting and preparing a food source by a predetermined quality guideline; (b) obtaining probiotics from the food source using a multi-purpose apparatus operable to function as either a centrifugal machine, a food mixer, and a fermentator; (c) screen testing the probiotics for viability and performances; (d) if the probiotics meet predetermined requirements for viability and performance standards, then record the predetermined quality guideline of said food source and parametric settings of said multi-purposed apparatus into a database for said food source; and (e) otherwise, repeating steps (a) to (c) until the probiotics meet the predetermined requirements for viability and performance standards.

Abstract: Provided are various embodiments relating to caninized TNF? antibodies and caninized NGF antibodies. Such antibodies can be used in methods to treat canines with inflammatory conditions, such as inflammatory bowel disease and/or in methods to treat canines with pain, such as osteoarthrititic pain, back pain, cancer pain, and/or a neuropathic pain.

Abstract: Provided are various embodiments relating to anti-IL31 antibodies binding to canine IL31. Such antibodies can be used in methods to treat IL31-induced conditions in companion animals, such as canines, felines, and equines.

Abstract: An apparatus including first and second substrates. The first and second substrates each include a base and at least one peripheral wall extending from the base. One of the at least one peripheral walls of the first or second substrates includes at least one well, and the other of the at least one peripheral walls of the first or the seconds substrate that does not include a well is mechanically anchored to the well. The apparatus includes a stack having a first and second end, and the stack is disposed on the base of the first and/or the second substrates at the first and/or second ends. The stack includes at least one element configured to generate energy. A method of assembling the apparatus by contacting the substrates.

Abstract: A system and methods of isolating probiotics and adding probiotics into matrices are disclosed, comprising: (a) selecting and preparing a food source by a predetermined quality guideline; (b) obtaining probiotics from the food source using a multi-purpose apparatus operable to function as either a centrifugal machine, a food mixer, and a fermentator; (c) screen testing the probiotics for viability and performances; (d) if the probiotics meet predetermined requirements for viability and performance standards, then record the predetermined quality guideline of said food source and parametric settings of said multi-purposed apparatus into a database for said food source; and (e) otherwise, repeating steps (a) to (c) until the probiotics meet the predetermined requirements for viability and performance standards.

Abstract: Provided are various embodiments relating to anti-IL4R antibodies that bind to canine IL4R. In various embodiments, such anti-IL4R antibodies can be used in methods to treat IL4/IL13-induced conditions, such as atopic dermatitis, allergic dermatitis, pruritus, asthma, psoriasis, scleroderma and eczema, in companion animals, such as canines and felines. Also provided are various embodiments relating to variant IgG Fc polypeptides and variant light chain constant regions of companion animal species for the preparation of antibodies or bispecific antibodies.

Abstract: A cloud computing capacity management system can include a fine-grained admission control layer, a policy engine, and an enforcement layer. The fine-grained admission control layer can be configured to ingest capacity signals and create a capacity mitigation policy, based at least in part on the capacity signals, to protect available capacity of a cloud computing system for prioritized users. The capacity mitigation policy can be directed to users of the cloud computing system. The policy engine can be configured to control how the capacity mitigation policy is applied to the cloud computing system. The enforcement layer can be configured to handle incoming resource requests and to enforce resource limits based on the capacity mitigation policy as applied by the policy engine.

Abstract: Embodiments generally relate to a system for managing media resources from a plurality of mobile devices and delivered by a vehicle. In particular, embodiments relate to an apparatus for providing a queue of media resources from a mobile device to a vehicle. The apparatus comprises a wireless transceiver, a vehicle interface, and a processor. The processor establishes a wireless connection to the mobile device and then receives a uniform resource identifier (URI) for a media resource from the mobile device. It then processes the URI to determine information on the media resource, including its media type and selects a media source associated with the media type that comprises the media resource. The processor next adds the media resource to the queue of media resources, which is broadcast via the wireless connection, and triggers the media source to provide the media resource to the vehicle via the vehicle interface.

Abstract: The invention relates to a body structure (3) for an electrically operable passenger vehicle, comprising at least one support element (9) with which the body structure (3) can be fixed in the region of a retaining contour (18) on at least one retaining element (13) of a conveyor system (I) in the production of the passenger vehicle. In order to allow both body structures (3) for bodies of passenger vehicles (ICE) provided with an internal combustion engine and for bodies of passenger vehicles (BEV, PHEV) provided with an electric drive to be retained, according to the invention, the retaining contour (18) is formed on the support element (9) at least partially via an adapter part (24) arranged on same.