Patents by Inventor Lambertus C. J. Dorssers

Lambertus C. J. Dorssers has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • N- and C-terminal truncation and deletion mutants of human interleukin-3
    Patent number: 5516512
    Abstract: Biologically active deletion and substitution mutants of hIL-3 are provided. Preferred mutants are those having one or more deletions at the N-terminus (amino acids 1-14) and/or the C-terminus (amino acids 116-133, 120-130 and/or 130-133). Preferred substitution mutants include Cys.sup.16 .fwdarw.Ala.sup.16 and/or Cys.sup.84 .fwdarw.Ala.sup.84, Glu.sup.50 .fwdarw.Lys.sup.50 and Lys.sup.79 .fwdarw.Glu.sup.79. These mutants can be used to formulate pharmaceutical compositions. Also disclosed are antibodies directed against specific epitopes localized between amino acids 29 and 54.
    Type: Grant
    Filed: November 8, 1993
    Date of Patent: May 14, 1996
    Assignee: Gist-brocades, N.V.
    Inventors: Lambertus C. J. Dorssers, Robert W. van Leen
  • Expression and purification of human interleukin-3 and muteins thereof
    Patent number: 5304637
    Abstract: Methods are provided for improved production of hIL-3 either in glycosylated form from mammalian and yeast cells or in unglycosylated form from prokaryotes. Recombinantly produced human IL-3 is purified in a series of steps, initially employing hydrophobic interaction, followed by ion exchange chromatography and gel filtration.
    Type: Grant
    Filed: March 13, 1990
    Date of Patent: April 19, 1994
    Assignee: Gist-brocades N.V.
    Inventors: Lambertus C. J. Dorssers, Gerard Wagemaker, Yvonne J. Vos, Robert W. Van Leen, Maria L. N. Persoon